Investigation of the inverse piezoelectric effect of trabecular bone on a micrometer length scale using synchrotron radiation

Wieland, D. C. Florian; Krywka, Christina; Mick, Enrico; Willumeit‐Römer, Regine; Bader, Rainer; Kluess, Daniel

doi:10.1016/j.actbio.2015.07.021

Cited by 22 publications

(18 citation statements)

References 36 publications

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“…One example is in long bones showing the accumulation of charges when exposed to mechanical stress or strain: On the concave side negative charges accumulate and bone formation can be observed, whereas positive charges and bone resorption occur on the convex side [13]. These effects are attributed to streaming potentials [14][15][16] and piezoelectricity [17][18][19]. Also, some studies hypothesize strong interdependencies between both phenomena [20,21].…”

Section: Introductionmentioning

confidence: 99%

Establishment of a Numerical Model to Design an Electro-Stimulating System for a Porcine Mandibular Critical Size Defect

Raben

Kämmerer²,

Bader

et al. 2019

Applied Sciences

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Electrical stimulation is a promising therapeutic approach for the regeneration of large bone defects. Innovative electrically stimulating implants for critical size defects in the lower jaw are under development and need to be optimized in silico and tested in vivo prior to application. In this context, numerical modelling and simulation are useful tools in the design process. In this study, a numerical model of an electrically stimulated minipig mandible was established to find optimal stimulation parameters that allow for a maximum area of beneficially stimulated tissue. Finite-element simulations were performed to determine the stimulation impact of the proposed implant design and to optimize the electric field distribution resulting from sinusoidal low-frequency ( f = 20 Hz ) electric stimulation. Optimal stimulation parameters of the electrode length h el = 25 m m and the stimulation potential φ stim = 0.5 V were determined. These parameter sets shall be applied in future in vivo validation studies. Furthermore, our results suggest that changing tissue properties during the course of the healing process might make a feedback-controlled stimulation system necessary.

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Section: Introductionmentioning

confidence: 99%

Establishment of a Numerical Model to Design an Electro-Stimulating System for a Porcine Mandibular Critical Size Defect

Raben

Kämmerer²,

Bader

et al. 2019

Applied Sciences

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“…As inspired by the piezoelectric property of bones, Yu et al designed the microscale piezoelectric zones (MPZs) with the use of K 0.5 Na 0.5 NbO 3 ceramics to guide the stem cell osteogenic differentiation in vitro and in vivo 4. Indeed, when an inverse piezoelectric effect was introduced to bone, the strain induced in bone matrix could stimulate the cellular activity of bone cells and then improved bone regeneration 5. When low‐intensity pulsed ultrasound (LIPUS) was applied to porous titanium alloy scaffold, the micromechanical strain induced by LIPUS would therefore initiate osteoblastic differentiation, bone formation and maturation as well as bony ingrowth in the porous scaffold 6.…”

Section: Introductionmentioning

confidence: 99%

Valence State Manipulation of Cerium Oxide Nanoparticles on a Titanium Surface for Modulating Cell Fate and Bone Formation

Wen

et al. 2017

Advanced Science

124

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Understanding cell–biomaterial interactions is critical for the control of cell fate for tissue engineering and regenerative medicine. Here, cerium oxide nanoparticles (CeONPs) are applied at different Ce4+/Ce3+ ratios (i.e., 0.46, 1.23, and 3.23) to titanium substrate surfaces by magnetron sputtering and vacuum annealing. Evaluation of the cytotoxicity of the modified surface to cultured rat bone marrow mesenchymal stem cells (BMSCs) reveals that the cytocompatibility and cell proliferation are proportional to the increases in Ce4+/Ce3+ ratio on titanium surface. The bone formation capability induced by these surface modified titanium alloys is evaluated by implanting various CeONP samples into the intramedullary cavity of rat femur for 8 weeks. New bone formation adjacent to the implant shows a close relationship to the surface Ce4+/Ce3+ ratio; higher Ce4+/Ce3+ ratio achieves better osseointegration. The mechanism of this in vivo outcome is explored by culturing rat BMSCs and RAW264.7 murine macrophages on CeONP samples for different durations. The improvement in osteogenic differentiation capability of BMSCs is directly proportional to the increased Ce4+/Ce3+ ratio on the titanium surface. Increases in the Ce4+/Ce3+ ratio also elevate the polarization of the M2 phenotype of RAW264.7 murine macrophages, particularly with respect to the healing‐associated M2 percentage and anti‐inflammatory cytokine secretion. The manipulation of valence states of CeONPs appears to provide an effective modulation of the osteogenic capability of stem cells and the M2 polarization of macrophages, resulting in favorable outcomes of new bone formation and osseointegration.

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“…Aschero et al investigated the converse piezoelectric effect of bone through measuring its bulk change induced by an electric field (Aschero et al, 1996). Wieland et al used X-ray micro-diffraction to study the inverse piezoelectric effect of bone and measured the shear strain induced in a femur by an electric field (Wieland et al, 2015). Itoh et al reported that charges induced by an external electric field can affect bone growth as well as osteoblast activity (Itoh et al, 2006), which indicated that electrical signals may play an important role in bone remodeling processes.…”

Section: Introductionmentioning

confidence: 99%

Experimental study of time response of bending deformation of bone cantilevers in an electric field

Kang

Hou

Qin

2018

Journal of the Mechanical Behavior of Biomedical Materials

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Bone is a complex composite material with hierarchical structures and anisotropic mechanical properties. Bone also processes electromechanical properties, such as piezoelectricity and streaming potentials, which termed as stress generated potentials. Furthermore, the electrostrictive effect and flexoelectric effect can also affect electromechanical properties of the bone. In the present work, time responses of bending deflections of bone cantilever in an external electric field are measured experimentally to investigate bone's electromechanical behavior. It is found that, when subjected to a square waveform electric field, a bone cantilever specimen begins to bend and its deflection increases gradually to a peak value. Then, the deflection begins to decrease gradually during the period of constant voltage. To analyze the reasons of the bending response of bone, additional experiments were performed. Experimental results obtained show the following two features. The first one is that the electric polarization, induced in bone by an electric field, is due to the Maxwell-Wagner polarization mechanism that the polarization rate is relatively slow, which leads to the electric field force acted on a bone specimen increase gradually and then its bending deflections increase gradually. The second one is that the flexoelectric polarization effect that resists the electric force to decrease and then leads to the bending deflection of a bone cantilever decrease gradually. It is concluded that the first aspect refers to the organic collagens decreasing the electric polarization rate of the bone, and the second one to the inorganic component influencing the bone's polarization intensity.

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Investigation of the inverse piezoelectric effect of trabecular bone on a micrometer length scale using synchrotron radiation

Cited by 22 publications

References 36 publications

Establishment of a Numerical Model to Design an Electro-Stimulating System for a Porcine Mandibular Critical Size Defect

Establishment of a Numerical Model to Design an Electro-Stimulating System for a Porcine Mandibular Critical Size Defect

Valence State Manipulation of Cerium Oxide Nanoparticles on a Titanium Surface for Modulating Cell Fate and Bone Formation

Experimental study of time response of bending deformation of bone cantilevers in an electric field

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