Investigation of the influence of progesterone on mouse embryo transport by using antiprogestational steroids

Kendle, K. E.; Lee, Bernadette

doi:10.1530/jrf.0.0580253

Cited by 21 publications

(6 citation statements)

References 17 publications

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“…Since there is an increase in progesterone production during the last part of oviducal transport in the mouse (McCormack & Greenwald, 1974; Barkley, Geschwind & Bradford, 1979), it appears that progesterone may be the factor that overrides the impediment to continued transport at this time. Although Kendle & Lee (1980) did not observe any effect of ovariectomy on Day 1 of pregnancy, they did inhibit ovum transport by administering antiprogestational steroids on Days 1, 2 or 3. These results support the suggestion that post-ovulatory progesterone secretion may be important for normal ovum transport.…”

Section: Introductionmentioning

confidence: 62%

“…The effects of ovariectomy on tubai transport in mice have been inconsistent. Whitney & Burdick (1939) reported a prolonged period of ovum transport in mice ovariectomized on Day 1 of pregnancy, while Kendle & Lee (1980) found a normal transport rate under similar conditions. Ovariectomy on Day 2 of pregnancy caused oviducal retention of the majority of ova until Day 4 (Roblero & Garavagno, 1979): daily administration of oestradiol-17ß during this period resulted in the passage of most ova through the oviduct but there was also a substantial loss of ova through the uterus; progesterone injections yielded a more normal transport of eggs.…”

Section: Introductionmentioning

confidence: 95%

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Effects of passive immunization against oestradiol on mouse ovum transport

Bigsby¹,

Lungu²,

Duby³

et al. 1983

Reproduction

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The ability of anti-oestradiol immunoglobulin to withhold oestradiol-17 beta from its target tissue was examined. The total oestradiol-17 beta binding capacity present in in-vitro incubations or injected into mice intravenously was related to the amount of [3H]oestradiol present in the media or intravenously injected into the animals respectively. When the ratio of binding capacity to [3H]oestradiol was above 74:1, [3H]oestradiol was successfully withheld from uterine tissue in vitro and in vivo. Injecting anti-oestradiol immunoglobulin into mice before administration of a tube-locking dose of oestradiol-17 beta ensured normal passage of ova through the oviduct. Daily administration of anti-oestradiol immunoglobulin to PMSG-hCG stimulated mice (starting 72 h before hCG injection) induced retention of ova for at least 2 days beyond the time when all ova had left the oviducts of control animals. The binding capacity: oestradiol-17 beta concentration ratios of sera from these animals were greater than 250:1 throughout the experimental period. Non-specific immunoglobulin had no such effects, indicating the specificity of the anti-oestradiol immunoglobulin response.

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Section: Introductionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 95%

Effects of passive immunization against oestradiol on mouse ovum transport

Bigsby¹,

Lungu²,

Duby³

et al. 1983

Reproduction

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“…Previous work (Kendle & Lee, 1980) has shown that post-ovulatory ovariectomy in mice does not affect tubai embryo transport. This is confirmed in the present study, but extended to show that ovariectomy combined with adrenalectomy results in significant retardation, which is abolished by concurrent administration of progesterone.…”

Section: Discussionmentioning

confidence: 83%

“…Previous studies of the influence of progesterone on mouse embryo transport have shown that the rate of transport was essentially unaltered by ovariectomy or progesterone administration after ovulation, but was increased by preovulatory progesterone treatment (Kendle & Lee, 1980). Further post-ovulatory administration of the antiprogestational steroids RMI 12,936 and R 2323 caused arrest or delay of transport and the effect of RMI 12,936 was abolished by exogenous progesterone.…”

Section: Introductionmentioning

confidence: 83%

Further investigation of the role of progesterone in the control of embryo transport in the mouse

Grieve¹,

Henwood²,

Kendle³

1985

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“…The corpora lutea are essential up to the end of pregnancy in mice (Deansely, 1966). The embryo transport process in mice is triggered by progesterone and requires progesterone activity for its maintenance (Kendle and Lee, 1980). In mice, 24 h of progesterone priming is not only adequate for implantation, but this priming has a long-term effect on implantation (Huet-Hudson and Dey, 1990).…”

Section: Discussionmentioning

confidence: 99%

Early pregnancy failure induced by dibutyltin dichloride in mice

Ema

Fujii²,

Ikka³

et al. 2007

Environmental Toxicology

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In this study, we examined the adverse effects of dibutyltin on initiation and maintenance of pregnancy after maternal administration during early pregnancy in mice. Following successful mating, female ICR mice were given dibutyltin dichloride (DBTCl) at 0, 7.6, 15.2, or 30.4 mg/kg bw/day by gastric intubation on days 0-3 or days 4-7 of pregnancy. Female mice were sacrificed on day 18 of pregnancy, and the pregnancy outcome was determined. After administration of DBTCl on days 0-3, the rate of nonpregnant females and the incidence of preimplantation embryonic loss were significantly increased at 30.4 mg/kg bw/day. The incidences of postimplantation embryonic loss in females given DBTCl on days 0-3 at 15.2 mg/kg and higher and on days 4-7 at 7.6 mg/kg bw/day and higher were increased. No increase in the incidence of fetuses with external malformations was observed after the administration of DBTCl on days 0-3 or days 4-7. A decline in the serum progesterone levels was detected in mice given DBTCl at 30.4 mg/kg bw/day on days 0-3 or days 4-7 of pregnancy. The data show that DBTCl adversely affects the initiation and maintenance of pregnancy when administered during early pregnancy in mice and suggest that the decline in serum progesterone levels is responsible for pregnancy failure. # 2007 Wiley Periodicals, Inc. Environ Toxicol 22: 44-52, 2007.

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Investigation of the influence of progesterone on mouse embryo transport by using antiprogestational steroids

Cited by 21 publications

References 17 publications

Effects of passive immunization against oestradiol on mouse ovum transport

Effects of passive immunization against oestradiol on mouse ovum transport

Further investigation of the role of progesterone in the control of embryo transport in the mouse

Early pregnancy failure induced by dibutyltin dichloride in mice

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