Investigation of the impacts of simple electrolytes and hydrotrope on the interaction of ceftriaxone sodium with cetylpyridinium chloride at numerous study temperatures

Abstract

Herein, interactions between cetylpyridinium chloride (CPC) and ceftriaxone sodium (CTS) were investigated applying conductivity technique. Impacts of the nature of additives (e.g. electrolytes or hydrotrope (HDT)), change of temperatures (from 298.15 to 323.15 K ), and concentration variation of CTS/additives were assessed on the micellization of CPC + CTS mixture. The conductometric analysis of critical micelle concentration (CMC) with respect to the concentration reveals that the CMC values were increased with the increase in CTS concentration. In terms of using different mediums, CMC did not differ much with the increase in electrolyte salt (NaCl, Na 2 SO 4 ) concentration, but increased significantly with the rise of HDT (NaBenz) amount. In the presence of electrolyte, CMC showed a gentle increment with temperature, while the HDT showed the opposite trend. Obtained result was further correlated with conventional thermodynamic relationship, where standard Gibb’s free energy change , change of enthalpy , and change of entropy ) were utilized to investigate. The values were negative for all the mixed systems studied indicating that the micellization process was spontaneous. Finally, the stability of micellization was studied by estimating the intrinsic enthalpy gain ( ) and compensation temperature ( T c ). Here, CPC + CTS mixed system showed more stability in Na 2 SO 4 medium than the NaCl, while in NaBenz exhibited the lowest stability.

Study on the association and phase separation behavior of surfactants and promethazine hydrochloride: impact of ammonium electrolytes

“…Although many works have been reported on the cloudy generation and micellization of surfactants in the manifestation of drugs, 38–45 the behavior of the respective processes in the presence of ammonium-based salts is still unknown. Rub et al 42 reported the phase partition and assembly of TX-100/TTAB + metformin hydrochloride drug solutions in different hydrotropic media.…”

“…Recently, we studied the interaction of TTAB/TX-100 with PMH in potassium salts/alcoholic additives. 44,45 Herein, we explore the impacts of (i) concentrations of ammonium-based electrolytes on CMC and CP of a working system, (ii) temperature on TTAB + PMH micellization in ammonium salt system; (iii) thermodynamic variables (free energy (Δ G 0 m /Δ G 0 c ), enthalpy (Δ H 0 m /Δ H 0 c ) and entropy (Δ S 0 m /Δ S 0 c )), and (iv) enthalpy–entropy compensation variables of micellization/clouding processes in the attendance of employed salts.…”

Association behavior and physico-chemical parameters of a cetylpyridinium bromide and levofloxacin hemihydrate mixture in aqueous and additive media

“…In the recent past, researchers have tirelessly engaged in investigating how medicines do interaction with surfactants, as surfactants are most frequently employed in the pharmaceutical industries and other applications. [1][2][3][4][5][6][7] These species have long been utilized in making drugs soluble in body uids and pharmaceutical production. It is essential to study the drug-surfactant interactions in order to create novel therapeutic formulations and pharmaceutical delivery methods.…”

Effect of Quaternary Ammonium Gemini Surfactant Solution on the Rate Constant of the Ninhydrin–Lysine Reaction

“…Aggregation structures generated by surfactants have gained remarkable attention owing to their unique phenomenon. − Due to their extraordinary behavior, − surfactants are engaged in diverge functions for several research purposes including industrial studies. They are employed in many sectors of fundamental as well as advanced applications. − The binding interaction of some active organic molecules with surfactants has been reported and displayed great importance in the arenas of surface chemistry. − Surfactants also work as a simple pseudophase model in several studies conducted by many potential investigators through micelle-involved reactions. − …”