Investigation of the impact of HLA-DPB1 matching status in 10/10 HLA matched unrelated hematopoietic stem cell transplantation: Results of a French single center study

Touzeau, Cyrille; Gagne, Katia; Sébille, Véronique; Herry, P.; Chevallier, Patrice; Folléa, Gilles; Devys, Anne; Moreau, Philippe; Mohty, Mohamad; Gautier, Anne Cesbron

doi:10.1016/j.humimm.2012.03.013

Cited by 8 publications

(13 citation statements)

References 18 publications

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“…However, TCE3 nonpermissive disparities had no significant impact on OS. 16 Moreover, we observed no significant impact of TCE3/TCE4 nonpermissive disparities on TRM as already reported in our unicentric study, 14 although TCE3 or TCE4 nonpermissive disparities were shown to significantly increase TRM in other multicentric studies. 9,13,16,20 The reported increase of overall mortality with nonpermissive TCE disparities was the result of a significant increase in non-relapse mortality, 13,16 the outcome of which was not evaluated in our study.…”

Section: Resultssupporting

confidence: 81%

Is there any impact of HLA-DPB1 disparity in 10/10 HLA-matched unrelated hematopoietic SCT? Results of a French multicentric retrospective study

Gagne¹,

Loiseau²,

Dubois³

et al. 2014

Bone Marrow Transplant

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We retrospectively analyzed the impact of HLA-DPB1 mismatches in a large cohort of 1342 French patients who underwent 10/10 HLA-matched unrelated HSCT. A significant impact of HLA-DPB1 allelic mismatches (2 vs 0) was observed in severe acute GVHD (aGVHD III-IV) (risk ratio (RR) = 1.73, confidence interval (CI) 95% 1.09-2.73, P = 0.019) without impact on OS, TRM, relapse and chronic GVHD (cGVHD). According to the T-cell epitope 3 (TCE3)/TCE4 HLA-DPB1 disparity algorithm, 37.6% and 58.4% pairs had nonpermissive HLA-DPB1, respectively. TCE3 and TCE4 disparities had no statistical impact on OS, TRM, relapse, aGVHD and cGVHD. When TCE3/TCE4 disparities were analyzed in the graft-vs-host or host-vs-graft (HVG) direction, only a significant impact of TCE4 nonpermissive disparities in the HVG direction was observed on relapse (RR = 1.34, CI 95% 1.00-1.80, P = 0.048). In conclusion, this French retrospective study shows an adverse prognosis of HLA-DPB1 mismatches (2 vs 0) on severe aGVHD and of nonpermissive TCE4 HVG disparities on relapse after HLA-matched 10/10 unrelated HSCT.

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Section: Resultssupporting

confidence: 81%

Is there any impact of HLA-DPB1 disparity in 10/10 HLA-matched unrelated hematopoietic SCT? Results of a French multicentric retrospective study

Gagne¹,

Loiseau²,

Dubois³

et al. 2014

Bone Marrow Transplant

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“…22 Unlikely, in the study of Touzeau et al from France, HLA-DPB1 non permissive disparities did not cause any adverse prognosis in terms of GVHD, survival or relapse in a series of patients who underwent 10/10 HLA matched unrelated ASCT. 23 In the study of Pidala et al, among 8/8 matched cases, HLA-DPB1 and -DQB1 mismatches resulted in increased aG-VHD, and HLA-DPB1 mismatch had decreased relapse. 24 In the study of Fleischhauer et al, nonpermissive mismatches associated with higher risks of TRM compared to permissive mismatches or allele matches.…”

Section: Discussionmentioning

confidence: 97%

“…[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] For instance, in the study by Loiseau et al reported increased frequency of severe aGVHD and poorer survival in two HLA-DP incompatibilities in a group of unrelated ASCT patients. 10 In this study they were not able show a significant relationship between HLA-DP mismatches and disease relapse.…”

Section: Discussionmentioning

confidence: 99%

Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey

Kantarcıoğlu¹

2017

UHOD

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In this study, we retrospectively examined 34 donor/recipient transplant pairs fully tested for the alleles HLA-A, B, C, DRB1, DQB1 and DPB1 in two different centers in Istanbul, Turkey. HLA-DPB1 disparity in at least one antigen level was 79.6% and only 20.6% of transplant pairs were fully identical for HLA-DPB1, in our study group. Neutrophil and thrombocyte engraftment successfully occurred in the entire study group. When the occurrence of severe (Grade III-IV) aGVHD was taken into account, we have observed that, non-permissive HLA-DPB1 mismatches were a significant factor for development of severe aGVHD (p= 0.019). There was a trend of increasing significance for the gut (p= 0.006) and liver (p: 0.054) aGVHD but not for skin aGVHD in non-permissive HLA-DPB1 mismatched transplantations. In multivariate analysis, non-permissive HLA-DPB1 mismatches remained as an independent factor for severe aGVHD. Our results did not show a significant impact of HLA-DPB1 mismatches on relapse. In survival analysis, both HLA-DPB1 disparities and non-permissive mismatches showed a decreasing trend of event free and overall survival times. Considering these results during donor selection may improve transplant outcomes in the setting of unrelated ASCT.

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“…4,22 This single-centre study considered the effects of mm HLA-DPB1, alone and in combination with 10 standard HLA alleles, in a cohort of patients all receiving in vivo T-cell depletion and PBSC as a stem cell source. Our population is representative of the core population undergoing transplantation for acute leukaemia and MDS.…”

Section: Discussionmentioning

confidence: 99%

“…However, this impact of T-cell epitope on outcomes has not been universally reported. 22 To date, the bulk of published data describe outcomes in T-cellreplete transplants, many performed more than 10 years ago, the majority using MA conditioning and BM as the stem cell source. Here, we present data from a standardized cohort of PBSC transplantation patients, all receiving in vivo T-cell depletion with alemtuzumab.…”

Section: Introductionmentioning

confidence: 99%

In a 12-allele analysis HLA-DPB1 matching is associated with improved OS in leukaemic and myelodysplastic patients receiving myeloablative T-cell-depleted PBSCT from unrelated donors

Burt

Parker

McQuaker

et al. 2014

Bone Marrow Transplant

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The effect on survival of including HLA-DPB1 in a 12-allele matching strategy was retrospectively evaluated in 130 patients with acute leukaemia and myelodysplasia undergoing T-cell-depleted PBSC transplantation using unrelated donors. Patients received alemtuzumab in vivo T-cell depletion as part of a myeloablative (MA; n ¼ 61) or reduced-intensity conditioning regimen (n ¼ 69). No difference in OS was seen with single-locus mismatching (mm) when 10 conventional alleles (HLA-A, B, C, DRB1 and DQB1) were considered. However, the addition of HLA-DPB1 matching data proved highly discriminatory. Mismatches were identified in 87% of patients previously considered fully matched (1DPmm ¼ 49pts: 2DPmm ¼ 28pts), and in the 9/10 group 22 patients were reclassified as double and 16 as triple mismatches. In 10/10 transplants, there was a distinct trend to poorer OS with double DPB1 mm. If all 12 loci were considered, 98% of single mm were at HLA-DPB1. Furthermore, cumulative mm at two or more loci was associated with significantly poorer 3-year OS (34% vs 48%, P ¼ 0.013: hazard ratio 1.8 (95% confidence interval 1.14-3.06; P ¼ 0.017), although his detrimental effect was only apparent using MA conditioning, in which reduced OS was associated with increased chronic GVHD (61% vs 16%, P ¼ 0.018) and nonrelapse mortality (30% vs 9%, P ¼ 0.039).

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Investigation of the impact of HLA-DPB1 matching status in 10/10 HLA matched unrelated hematopoietic stem cell transplantation: Results of a French single center study

Cited by 8 publications

References 18 publications

Is there any impact of HLA-DPB1 disparity in 10/10 HLA-matched unrelated hematopoietic SCT? Results of a French multicentric retrospective study

Is there any impact of HLA-DPB1 disparity in 10/10 HLA-matched unrelated hematopoietic SCT? Results of a French multicentric retrospective study

Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey

In a 12-allele analysis HLA-DPB1 matching is associated with improved OS in leukaemic and myelodysplastic patients receiving myeloablative T-cell-depleted PBSCT from unrelated donors

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