Investigation of the <i>COMT</i> Val158Met variant association with age of onset of psychosis, adjusting for cannabis use

Lodhi, Rohit J.; Wang, Yabing; Rossolatos, David; Macintyre, Georgina; Bowker, Alexandra; Crocker, Candice E.; Ren, Hongyan; Dimitrijević, Aleksandra; Bugbee, Darren A.; Loverock, Alexandra; Majeau, Brett; Sivapalan, Sudhakar; Newton, Virginia M.; Tibbo, Philip G.; Purdon, Scot E.; Aitchison, Katherine J.

doi:10.1002/brb3.850

Cited by 10 publications

(11 citation statements)

References 53 publications

(65 reference statements)

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“…Regarding the COMT gene, several studies have shown the Val158Met genotype to be a moderator of the association between cannabis use and the later development of a psychotic disorder, with the highest risk for Val carriers [61][62][63][64]. However, a significant number of studies have failed to show an impact on the relationship between cannabis and psychosis [65][66][67][68][69]. As was also concluded by a recent meta-analysis [105], an association between the COMT Val158Met genotype, cannabis use, and psychosis cannot be proven at the moment, accounting for the dissimilarity in results.…”

Section: Discussionmentioning

confidence: 99%

“…They reported that early cannabis use and the presence of the COMT Val158Met polymorphism were not significantly associated with an earlier onset of psychosis [68]. Another study published in 2017 by Lodhi and colleagues failed to demonstrate a significant moderating effect of the COMT genotype on the age of psychosis onset in cannabis users that initiated use before 20 years of age (P = 0.051) [69].…”

Section: Comt Genementioning

confidence: 98%

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Factors Moderating the Association between Cannabis Use and Psychosis Risk: A Systematic Review

2020

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Increasing evidence indicates a relationship between cannabis use and psychosis risk. Specific factors, such as determinants of cannabis use or the genetic profile of cannabis users, appear to moderate this association. The present systematic review presents a detailed and up-to-date literature overview on factors that influence the relationship between cannabis use and psychosis risk. A systematic search was performed according to the PRISMA guidelines in MEDLINE and Embase, and 56 studies were included. The results show that, in particular, frequent cannabis use, especially daily use, and the consumption of high-potency cannabis are associated with a higher risk of developing psychosis. Moreover, several genotypes moderate the impact of cannabis use on psychosis risk, particularly those involved in the dopamine function, such as AKT1. Finally, cannabis use is associated with an earlier psychosis onset and increased risk of transition in individuals at a clinical high risk of psychosis. These findings indicate that changing cannabis use behavior could be a harm reduction strategy employed to lower the risk of developing psychosis. Future research should aim to further develop specific biomarkers and genetic profiles for psychosis, thereby contributing to the identification of individuals at the highest risk of developing a psychotic disorder.

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Section: Discussionmentioning

confidence: 99%

Section: Comt Genementioning

confidence: 98%

Factors Moderating the Association between Cannabis Use and Psychosis Risk: A Systematic Review

2020

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“…[38][39][40][41] Molecular genetic research demonstrates that another key factor influencingthedegreeofriskconferredby cannabis use for developing schizophreniaorpsychosisishavingafamilyhistory of these disorders. 37,[42][43][44][45][46] Although it has been reported that some genetic risk factorsunderlieboththeriskfordeveloping schizophrenia and for initiating cannabis use, 47,48 cannabisuseonitsownisstillan independent risk factor for psychosis and related mental disorders such as schizophrenia.…”

Section: Increasing Thc Content In Cannabis Products Available In Thementioning

confidence: 99%

Psychotic disorder and cannabis use: Canadian hospitalization trends, 2006–2015

Maloney‐Hall

Wallingford

Konefal

et al. 2020

Health Promot Chronic Dis Prev Can

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Introduction Given the recent and impending changes to the legal status of nonmedical cannabis use in Canada, understanding the effects of cannabis use on the health care system is important for evaluating the impact of policy change. The aim of this study was to examine pre-legalization trends in hospitalizations for mental and behavioural disorders due to the use of cannabis, according to demographics factors and clinical conditions. Methods We assessed the total number of inpatient hospitalizations for psychiatric conditions with a primary diagnosis of a mental or behavioural disorder due to cannabis use (ICD-10-CA code F12) from the Hospital Mental Health Database for ten years spanning 2006 to 2015, inclusive. We included hospitalizations from all provinces and territories except Quebec. Rates (per 100 000 persons) and relative proportions of hospitalizations by clinical condition, age group, sex and year are reported. Results Between 2006 and 2015, the rate of cannabis-related hospitalizations in Canada doubled. Of special note, however, is that hospitalizations during this time period for those with the clinical condition code "mental and behavioural disorders due to use of cannabinoids, psychotic disorder" (F12.5) tripled, accounting for almost half (48%) of all cannabis-related hospitalizations in 2015. Conclusion Further research is required to investigate the reasons for the increase in hospitalizations for cannabis-related psychotic disorder. The introduction of high-potency cannabinoid products and synthetic cannabinoids into the illicit market are considered as possible factors.

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“…The COMT rs4680 SNP is genotyped using a TaqMan ® SNP Genotyping Assay on an Applied Biosystems ViiA ™ 7 Real-Time PCR System (ThermoFisher Scientific, Canada, formerly Applied Biosystems by Life Technologies, Canada) as previously described (98). Furthermore, 5-HTTLPR variant is genotyped as previously described, with minor modifications (99), with primer sequences of 5′-ATG CCA GCA CCT AAC CCC TAA TGT (forward) and 5′-GGA CCG CAA GGT GGG CGG GA (reverse).…”

Section: Methodsmentioning

confidence: 99%

Prediction and Understanding of Resilience in Albertan Families: Longitudinal Study of Disaster Responses (PURLS) – Protocol

et al. 2019

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Exposure to a natural disaster in childhood can have serious, long-lasting consequences, impacting physical and mental health, development, and learning. Although many children experience negative effects after a disaster, the majority do not, and what differentiates these groups is not well understood. Some of the factors that influence disaster-related outcomes in the midst of adversity include parents’ mental health, the home environment, and socioeconomic status. Furthermore, genetics has also a role to play in how children respond to stressors. We had the opportunity to conduct a natural experiment of disaster recovery following the Alberta 2013 Flood. This paper presents the detailed protocol on prediction of resilience in Albertan families, and validation with cortisol data. In addition, data collection procedures, developing resiliency screening tools, candidate gene identification, genotyping, DNA methylation, and genomic analyses are described to achieve the research objectives. This study produced new knowledge by using pre- and post-disaster information on children’s health and development, including children’s genetics and responses to stress. This information has been identified as important to governments and other organizations invested in early child development. Our comprehensive research plan generates evidence that can be mobilized population-based approaches to improve child and family resiliency.

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Investigation of the COMT Val158Met variant association with age of onset of psychosis, adjusting for cannabis use

Cited by 10 publications

References 53 publications

Factors Moderating the Association between Cannabis Use and Psychosis Risk: A Systematic Review

Factors Moderating the Association between Cannabis Use and Psychosis Risk: A Systematic Review

Psychotic disorder and cannabis use: Canadian hospitalization trends, 2006–2015

Prediction and Understanding of Resilience in Albertan Families: Longitudinal Study of Disaster Responses (PURLS) – Protocol

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