Investigation of the Fused Deposition Modeling Additive Manufacturing I: Influence of Process Temperature on the Quality and Crystallinity of the Dosage Forms

Zhang, Jiaxiang; Thakkar, Rishi; Kulkarni, Vineet; Lu, Anqi; Maniruzzaman, Mohammed

doi:10.1208/s12249-021-02094-8

Cited by 9 publications

(3 citation statements)

References 25 publications

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“…While interest in pharmaceutical 3DP continues to grow, with pharmaceutical companies such as Aprecia and Triastek investing in the technology, progress is arguably hampered by the empirical process of formulation development ( Elbadawi et al, 2021b ; Seoane-Viaño et al, 2021 ). The entire process of HME and FDM 3DP typically involves iterative adjustments to the formulation composition and/or numerous printing parameters such as the extrusion speed and temperature, the printing speed and temperature, the layer height, the percentage infill, and the platform temperature ( Đuranović et al, 2021 ; Govender et al, 2021 ; Henry et al, 2021 ; Zhang et al, 2021 ). Given the multifactorial nature of HME and FDM 3DP, conventional systemic methods of evaluating each input variable on printing success (i.e., based on design of experiments) can be time-consuming.…”

Section: Introductionmentioning

confidence: 99%

Accelerating 3D printing of pharmaceutical products using machine learning

Ong

Castro

Gaisford

et al. 2022

International Journal of Pharmaceutics: X

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Section: Introductionmentioning

confidence: 99%

Accelerating 3D printing of pharmaceutical products using machine learning

Ong

Castro

Gaisford

et al. 2022

International Journal of Pharmaceutics: X

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“…This can be attributed to the thinning contributed by the forces applied by the puller, and to the immediate swelling of the filaments post-heating from the extrusion process followed by the contraction on cooling. The swell ratio increases as the processing temperature and the temperature of the extrudates at the outlet increase [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

Veering to a Continuous Platform of Fused Deposition Modeling Based 3D Printing for Pharmaceutical Dosage Forms: Understanding the Effect of Layer Orientation on Formulation Performance

et al. 2023

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Three-dimensional (3D) printing of pharmaceuticals has been centered around the idea of personalized patient-based ‘on-demand’ medication. Fused deposition modeling (FDM)-based 3D printing processes provide the capability to create complex geometrical dosage forms. However, the current FDM-based processes are associated with printing lag time and manual interventions. The current study tried to resolve this issue by utilizing the dynamic z-axis to continuously print drug-loaded printlets. Fenofibrate (FNB) was formulated with hydroxypropyl methylcellulose (HPMC AS LG) into an amorphous solid dispersion using the hot-melt extrusion (HME) process. Thermal and solid-state analyses were used to confirm the amorphous state of the drug in both polymeric filaments and printlets. Printlets with a 25, 50, and 75% infill density were printed using the two printing systems, i.e., continuous, and conventional batch FDM printing methods. Differences between the two methods were observed in the breaking force required to break the printlets, and these differences reduced as the infill density went up. The effect on in vitro release was significant at lower infill densities but reduced at higher infill densities. The results obtained from this study can be used to understand the formulation and process control strategies when switching from conventional FDM to the continuous printing of 3D-printed dosage forms.

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“…Fused Deposition Modeling (FDM) is an extremely popular 3D printing technique that is widely employed for manufacturing a wide variety of products. The adaptation of this technique in tablet manufacturing has opened new venues for the design of unique formulations ( 7 ). The hot-melt extrusion coupled dual nozzle printing of an FDM process delivered bilayer tablets for independent drug release profiles ( 8 ).…”

Section: Types Of 3d Printingmentioning

confidence: 99%

3D printing of pharmaceuticals for disease treatment

Chakka

Chede

2023

Front. Med. Technol.

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Three-dimensional (3D) printing or Additive manufacturing has paved the way for developing and manufacturing pharmaceuticals in a personalized manner for patients with high volume and rare diseases. The traditional pharmaceutical manufacturing process involves the utilization of various excipients to facilitate the stages of blending, mixing, pressing, releasing, and packaging. In some cases, these excipients cause serious side effects to the patients. The 3D printing of pharmaceutical manufacturing avoids the need for excessive excipients. The two major components of a 3D printed tablet or dosage form are polymer matrix and drug component alone. Hence the usage of the 3D printed dosage forms for disease treatment will avoid unwanted side effects and provide higher therapeutic efficacy. With respect to the benefits of the 3D printed pharmaceuticals, the present review was constructed by discussing the role of 3D printing in producing formulations of various dosage forms such as fast and slow releasing, buccal delivery, and localized delivery. The dosage forms are polymeric tablets, nanoparticles, scaffolds, and films employed for treating different diseases.

show abstract

Investigation of the Fused Deposition Modeling Additive Manufacturing I: Influence of Process Temperature on the Quality and Crystallinity of the Dosage Forms

Cited by 9 publications

References 25 publications

Accelerating 3D printing of pharmaceutical products using machine learning

Accelerating 3D printing of pharmaceutical products using machine learning

Veering to a Continuous Platform of Fused Deposition Modeling Based 3D Printing for Pharmaceutical Dosage Forms: Understanding the Effect of Layer Orientation on Formulation Performance

3D printing of pharmaceuticals for disease treatment

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