Investigation of the formation and properties of water-soluble conjugates of polymer p-nitrophenyl esters with polymer primary amines

Solovskij, M. V.; Panarin, E. F.; Gorbunova, O. P.; Корнеева, Е. В.; Petuhkova, N.A.; Michajlova, N.A.

doi:10.1016/s0014-3057(99)00188-3

Cited by 11 publications

(9 citation statements)

References 4 publications

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“…On one hand, the toxicity of trichlorophenol limited the use of TCP-based polymers, while on the other hand, the hydrolytic susceptibility of NHB-based polyesters raised the question of their long lasting stability. Rejmanova and Kopecek copolymerized a new class of methacrylate monomer, p -nitro phenyl methacrylate (PNPMA) (Table ), with N -(2-hydroxypropyl)-methacrylamide (HPMA) under free radical polymerization. − However, incorporation of PNPMA within the copolymer resulted in a low polymerization yield as also observed by Okawara et al for poly(styrene- co -PNPA) . For a series of copolymers of p -nitrophenyl acrylate (PNPA) with styrene, methyl acrylate, and N,N -dimethylacrylamide (DMA), the rate of aminolysis was studied in dioxane and chlorobenzene .…”

Section: Methods Of Preparation Of Polymers With Pendent Activated Es...mentioning

confidence: 82%

Activated Ester Containing Polymers: Opportunities and Challenges for the Design of Functional Macromolecules

2015

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Section: Methods Of Preparation Of Polymers With Pendent Activated Es...mentioning

confidence: 82%

Activated Ester Containing Polymers: Opportunities and Challenges for the Design of Functional Macromolecules

2015

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“…Recently, polymer colloids with enzymes and antibodies are expected to have applications as diagnostic agents and transfer to specific cells and organs [1][2]. The polymer has the suitable hydrophobic domain for spontaneous association, and it is the most important part in the preparation of polymer colloids.…”

Section: Introductionmentioning

confidence: 99%

“…The MEONP segment in Poly(PP 1000 MEONP) possesses an active ester group in the side chain, which can react with specific biomolecules that have an amino group [2][3].…”

Section: Introductionmentioning

confidence: 99%

Polymer Colloid Formation with Oligo Hydrophilic and Hydrophobic Chains for Bioconjugation

Kanbe

Watanabe

Ikeda

2013

Trans. Mat. Res. Soc. Japan

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We investigated the bioconjugation on polymer colloids covered with a bioinert poly(ethylene glycol) chain. The polymer colloids would be expected to carry out a specific enzymatic reaction by conjugation of a substance at the shell part of the colloids. Therefore, the conjugated polymer colloid surface needs to possess a property for the conjugation of functional molecules. In this study, a water-soluble amphiphilic graft polymer with a substrate specific to the enzyme was designed to possess surface modification of the enzyme-substrate complex. The graft copolymer composed of hydrophilic and hydrophobic side chains was created by a new molecular design. The macromonomer with an oligo hydrophilic chain was modified by using p-nitrophenyl chloroformate to obtain the macromonomer with an active ester group (MEONP). The graft copolymer was prepared by conventional radical polymerization using poly(propylene glycol) methacrylate and MEONP. Their solution properties in an aqueous medium were also analyzed by using fluorescence measurement of sodium 8-anilino-1-naphthalene sulfonate (ANS) as a fluorescence probe to evaluate the hydrophobic domain in the polymer colloids, and were also measured by dynamic light scattering to determine the particle size. The conjugation efficiency was determined by UV-Vis spectroscopy at 400 nm.

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“…BMA is the hydrophobic unit, and the MEONP unit has an active ester group in the side chain. The MEONP unit can react with other functional groups or a specific biomolecule [21,22]. This provides the possibility of functionalizing the polymer for specific applications.…”

Section: Introductionmentioning

confidence: 99%

Feasibility Study of Introducing Redox Property by Modification of PMBN Polymer for Biofuel Cell Applications

Himuro

Takai

et al. 2009

Appl Biochem Biotechnol

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In this study, the feasibility of introducing redox property to an amphiphilic phospholipid polymer (PMBN) was investigated. The active ester group in the side chain of the polymer was used to react with pyrroloquinoline quinine (PQQ). Redox peaks that corresponded to PQQ redox potentials were observed after the modification. Glucose oxidase was immobilized to the modified polymer. Electrochemical oxidation of glucose was carried out with the polymer electrode. The oxidation current increased with elevating glucose concentration indicating electron transfer established between the electrode and enzyme. It suggests that by modification, PMBN is possible to use for enzyme electrode for bioelectronics.

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Investigation of the formation and properties of water-soluble conjugates of polymer p-nitrophenyl esters with polymer primary amines

Cited by 11 publications

References 4 publications

Activated Ester Containing Polymers: Opportunities and Challenges for the Design of Functional Macromolecules

Activated Ester Containing Polymers: Opportunities and Challenges for the Design of Functional Macromolecules

Polymer Colloid Formation with Oligo Hydrophilic and Hydrophobic Chains for Bioconjugation

Feasibility Study of Introducing Redox Property by Modification of PMBN Polymer for Biofuel Cell Applications

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