Investigation of the first outbreak of OXA-48-producing Klebsiella pneumoniae in Ireland

Wrenn, C.; O’Brien, Dónal; Keating, D.; Roche, Claudine; Rose, Lisa; Ronayne, Aoife; Fenelon, Lynda; Fitzgerald, Susan; Crowley, Brendan; Schaffer, Kirsten

doi:10.1016/j.jhin.2014.03.001

Cited by 23 publications

(14 citation statements)

References 22 publications

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“…In 2011, an outbreak of epidemiologically-related KPC-producing K. pneumoniae in two hospitals from two different regions resulted in epidemiological stage 4 of CPE spread in the country [17]. This was concomitant with the first hospital outbreak of OXA-48-producing K. pneumoniae [18]. Since 2013, although the spread of CPE was limited to regional spread in some regions, the overall national situation is considered to have worsened due to an increase in the overall number of reported CPE cases.…”

Section: Ireland and United Kingdommentioning

confidence: 99%

Carbapenemase-producing Enterobacteriaceae in Europe: assessment by national experts from 38 countries, May 2015

et al. 2015

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In 2012, the European Centre for Disease Prevention and Control (ECDC) launched the 'European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE)' project to gain insights into the occurrence and epidemiology of carbapenemase-producing Enterobacteriaceae (CPE), to increase the awareness of the spread of CPE, and to build and enhance the laboratory capacity for diagnosis and surveillance of CPE in Europe. Data collected through a post-EuSCAPE feedback questionnaire in May 2015 documented improvement compared with 2013 in capacity and ability to detect CPE and identify the different carbapenemases genes in the 38 participating countries, thus contributing to their awareness of and knowledge about the spread of CPE. Over the last two years, the epidemiological situation of CPE worsened, in particular with the rapid spread of carbapenem-hydrolysing oxacillinase-48 (OXA-48)- and New Delhi metallo-beta-lactamase (NDM)-producing Enterobacteriaceae. In 2015, 13/38 countries reported inter-regional spread of or an endemic situation for CPE, compared with 6/38 in 2013. Only three countries replied that they had not identified one single case of CPE. The ongoing spread of CPE represents an increasing threat to patient safety in European hospitals, and a majority of countries reacted by establishing national CPE surveillances systems and issuing guidance on control measures for health professionals. However, 14 countries still lacked specific national guidelines for prevention and control of CPE in mid-2015.

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Section: Ireland and United Kingdommentioning

confidence: 99%

Carbapenemase-producing Enterobacteriaceae in Europe: assessment by national experts from 38 countries, May 2015

et al. 2015

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“…OXA-48-producing K. pneumoniae was recently also detected in Canada ( Ellis et al, 2013 ), the USA ( Mathers et al, 2013 ), Ireland ( Wrenn et al, 2014 ), Poland ( Izdebski et al, 2015 ), Hungary ( Janvari et al, 2014 ), Greece ( Voulgari et al, 2013 ), Romania ( Lixandru et al, 2015 ), Bulgaria ( Markovska et al, 2015 ), Finland ( Osterblad et al, 2012 ), Russia ( Fursova et al, 2015 ), Algeria ( Cuzon et al, 2015 ), United Arab Emirates ( Ahn et al, 2015 ), Iran ( Azimi et al, 2014 ), South Africa ( Brink et al, 2013 ), Senegal ( Moquet et al, 2011 ), Taiwan ( Ma et al, 2015 ), Singapore ( Ling et al, 2015 ), South Korea ( Jeong et al, 2015 ), and Australia ( Espedido et al, 2013 ; Figure 4 ). In North America, the frequency of OXA-48-like enzymes among carbapenemase-producing K. pneumoniae isolates was very low (11%; Lascols et al, 2013 ).…”

Section: The Epidemiology Genetic Context Treatment Options and Dementioning

confidence: 99%

Global Dissemination of Carbapenemase-Producing Klebsiella pneumoniae: Epidemiology, Genetic Context, Treatment Options, and Detection Methods

et al. 2016

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The emergence of carbapenem-resistant Gram-negative pathogens poses a serious threat to public health worldwide. In particular, the increasing prevalence of carbapenem-resistant Klebsiella pneumoniae is a major source of concern. K. pneumoniae carbapenemases (KPCs) and carbapenemases of the oxacillinase-48 (OXA-48) type have been reported worldwide. New Delhi metallo-β-lactamase (NDM) carbapenemases were originally identified in Sweden in 2008 and have spread worldwide rapidly. In this review, we summarize the epidemiology of K. pneumoniae producing three carbapenemases (KPCs, NDMs, and OXA-48-like). Although the prevalence of each resistant strain varies geographically, K. pneumoniae producing KPCs, NDMs, and OXA-48-like carbapenemases have become rapidly disseminated. In addition, we used recently published molecular and genetic studies to analyze the mechanisms by which these three carbapenemases, and major K. pneumoniae clones, such as ST258 and ST11, have become globally prevalent. Because carbapenemase-producing K. pneumoniae are often resistant to most β-lactam antibiotics and many other non-β-lactam molecules, the therapeutic options available to treat infection with these strains are limited to colistin, polymyxin B, fosfomycin, tigecycline, and selected aminoglycosides. Although, combination therapy has been recommended for the treatment of severe carbapenemase-producing K. pneumoniae infections, the clinical evidence for this strategy is currently limited, and more accurate randomized controlled trials will be required to establish the most effective treatment regimen. Moreover, because rapid and accurate identification of the carbapenemase type found in K. pneumoniae may be difficult to achieve through phenotypic antibiotic susceptibility tests, novel molecular detection techniques are currently being developed.

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“…html). The epidemic K. pneumoniae ST1853 is a single-locus variant of ST13, an internationally disseminated clone, which has been found to carry the bla OXA-48 gene in Ireland and Finland [5].…”

mentioning

confidence: 99%

First outbreak of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Constantine, Algeria

Cuzon

Bentchouala

Vogel

et al. 2015

International Journal of Antimicrobial Agents

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Investigation of the first outbreak of OXA-48-producing Klebsiella pneumoniae in Ireland

Cited by 23 publications

References 22 publications

Carbapenemase-producing Enterobacteriaceae in Europe: assessment by national experts from 38 countries, May 2015

Carbapenemase-producing Enterobacteriaceae in Europe: assessment by national experts from 38 countries, May 2015

Global Dissemination of Carbapenemase-Producing Klebsiella pneumoniae: Epidemiology, Genetic Context, Treatment Options, and Detection Methods

First outbreak of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Constantine, Algeria

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