Investigation of the effects of the royal jelly on genomic demethylation and tumor suppressor genes in human cancer cells

Köprülü, Tuğba Kul; Erkal, Burçin; Kara, Altan; Teki̇n, Şaban

doi:10.1007/s12032-022-01927-1

Cited by 2 publications

(1 citation statement)

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“… 85 UHRF1 inhibition in A549 lung adenocarcinoma cells resulted in lower methylation levels of RASSF1, indicating that UHRF1 plays an important role upstream in the regulation of DNMT1/RASSF1A pathway. 85 Interestingly, the treatment of A549 lung adenocarcinoma cells by RJ decreased DNMT1 expression and increased RASSF1A expression, 86 which indicates that the decrease in DNMT1-mediated methylation of RASSF1A gene promoter in response to RJ treatment could result of direct inhibitory effects of this diet on UHRF1 expression. Second, through its SRA and ubiquitin-like domains, UHRF1 interacts with DNMT3A, resulting in the epigenetic silencing of the cytomegalovirus promoter in embryonic stem cells.…”

Section: A Look At Future Directions In Epigenetics Mechanisms Of Hon...mentioning

confidence: 99%

Epigenetics Mechanisms of Honeybees: Secrets of Royal Jelly

Alhosin

2023

Genet Epigenet

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Early diets in honeybees have effects on epigenome with consequences on their phenotype. Depending on the early larval diet, either royal jelly (RJ) or royal worker, 2 different female castes are generated from identical genomes, a long-lived queen with fully developed ovaries and a short-lived functionally sterile worker. To generate these prominent physiological and morphological differences between queen and worker, honeybees utilize epigenetic mechanisms which are controlled by nutritional input. These mechanisms include DNA methylation and histone post-translational modifications, mainly histone acetylation. In honeybee larvae, DNA methylation and histone acetylation may be differentially altered by RJ. This diet has biologically active ingredients with inhibitory effects on the de novo methyltransferase DNMT3A or the histone deacetylase 3 HDAC3 to create and maintain the epigenetic state necessary for developing larvae to generate a queen. DNMT and HDAC enzymes work together to induce the formation of a compacted chromatin structure, repressing transcription. Such dialog could be coordinated by their association with other epigenetic factors including the ubiquitin-like containing plant homeodomain (PHD) and really interesting new gene (RING) ﬁnger domains 1 (UHRF1). Through its multiple functional domains, UHRF1 acts as an epigenetic reader of both DNA methylation patterns and histone marks. The present review discusses the epigenetic regulation of honeybee’s chromatin and how the early diets in honeybees can affect the DNA/histone modifying types of machinery that are necessary to stimulate the larvae to turn into either queen or worker. The review also looks at future directions in epigenetics mechanisms of honeybees, mainly the potential role of UHRF1 in these mechanisms.

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Section: A Look At Future Directions In Epigenetics Mechanisms Of Hon...mentioning

confidence: 99%