Investigation of the effects of therapeutic ultrasound or photobiomodulation and the role of spinal glial cells in osteoarthritis-induced nociception in mice

Malta, Iago Henrique Silva; Moraes, Thamyris Reis; Elisei, Lívia; Novaes, Rômulo Dias; Galdino, Giovane

doi:10.1007/s10103-021-03418-7

Cited by 3 publications

(3 citation statements)

References 42 publications

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“…These parts are coordinated and completed together. In addition, the physical confrontation in football is fierce, and the sudden stop and start, jumping, and variable speed running will cause repeated and high-intensity wear and tear to the body, so the sports injury rate in football is relatively high [ 4 ]. Endstrasser et al pointed out in the study that the characteristics of football sports are high intensity, high confrontation, and physical contact.…”

Section: Literature Reviewmentioning

confidence: 99%

Observation on the Effect of MRI Image Scanning on Knee Pain in Football Injury

Wei-dong

2022

Scanning

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To study the effect of football injury on knee pain based on MRI image scanning, in this paper, a total of 31 knee injuries of 29 male professional football players from December 2012 to April 2015 were used as the experimental group. The players were 23.6 ± 3.5 years old and received professional football training time 15.3 ± 3.6 years; 31 outpatients of the same age group with acute knee joint acute injury were randomly selected as the control group; both groups were imaged with a 1.5 TMR scanner and knee joint standard array coil imaging, and 2 senior radiation surgeons evaluate knee cartilage, meniscus, ligaments, tendons, bone marrow, infrapatellar fat pad, and joint effusions. Pearson’s chi-squared test and nonparametric test for two independent samples were used for statistical testing of the evaluation results. The experimental results showed that there were significant differences in the incidence of articular cartilage, lateral collateral ligament, tendon or ligament injury, multiligament or tendon injury, and bone marrow edema between the two groups ( P < 0.05 ). There was no significant difference in the incidence of medial collateral ligament injury, infrapatellar fat pad edema, and joint effusion. MRI shows that knee injuries in male professional football players often involve ligaments or tendons, mostly multiligament or tendon injuries. The lesions of articular cartilage and meniscus are more common and serious, and bone marrow edema is also more common in football injuries. MRI has high diagnostic accuracy for various clinical knee injuries, and it belongs to a noninvasive examination method. It can not only reflect the pathological changes and changes of the knee joints of patients but also provide information for the formulation of clinical programs and the judgment of prognosis, for timely, accurate, and comprehensive imaging reference.

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Section: Literature Reviewmentioning

confidence: 99%

Observation on the Effect of MRI Image Scanning on Knee Pain in Football Injury

Wei-dong

2022

Scanning

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“…Following a final wash, a chromogenic solution was added and colorimetric reactions were analyzed at 405 nm with 630 nm correction using a microplate reader (Sinergy H1, Biotek instruments, Winooski, GU, USA). Cytokine levels in spinal cord samples were calculated using standard curves obtained from different concentrations of all analyzed molecules [7].…”

Section: Methodsmentioning

confidence: 99%

Synergistic effect of cannabidiol and transcutaneous electrical nerve stimulation on neuropathic and inflammatory pain in mice

et al. 2023

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Objectives Pain is the most common cause of seeking healthcare and the leading cause of disability worldwide. Although cannabidiol and transcutaneous electrical nerve stimulation (TENS) are effective and safe strategies for treating chronic pain, the combined effect of these interventions remains overlooked. To compare the isolated and combined effect of cannabidiol and TENS in the treatment of experimental neuropathic and inflammatory pain. Methods Swiss mice were subjected to chronic constriction injury (CCI)-induced neuropathic or carrageenan-induced inflammatory pain models. Cannabidiol or TENS alone and the combination of these therapies were administered once. The nociceptive threshold was measured by the von Frey test. IL-1β, TNF-α and IL-10 cytokine levels were measured by ELISA from spinal cord samples. Results Combined, cannabidiol and TENS potentiate antinociception only in neuropathic pain. IL-1β and TNF-α levels were similarly reduced when TENS or cannabidiol were administered alone or in combination. However, only cannabidiol and TENS combined increased IL-10 levels. Conclusions Our findings indicated TENS and cannabidiol combined were effective in potentiating antinociception in a neuropathic pain model, an effect potentially associated with spinal IL-10 upregulation.

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“…[70] Furthermore, US has also been demonstrated can attenuate inflammatory response during the PNR process through suppressing inflammatory cytokines expression (i.e., TNF-α and IL-6) and facilitating SCs redifferentiation and remyelination to promote myelin thickening (Figure 3b). [71][72][73][74][75][76]…”

Section: Mechanism Of Electrical Stimulation For Promotion Of Pnrmentioning

confidence: 99%

Physical Cue‐Based Strategies on Peripheral Nerve Regeneration

Wei

Jin

et al. 2022

Adv Funct Materials

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Peripheral nerve injury (PNI) remains an intractable challenge in regenerative medicine. Recently, physical cue-based strategies (e.g., electrical neurostimulation, acoustic radiation, electromagnetic bioregulation, as well as directional fiber guiding, etc.) have drawn increasing attention not only as a stimulator for cell functions modulation and fate determination, but also as a morphology-index for modulating cell phenotype, proliferation, and differentiation, especially for nerve cells. More importantly, the advanced percutaneous power transmission technology, self-power nanotechnology that leverages piezoelectrical/triboelectricity materials, and focused ultrasound and pulsed electromagnetic field technology exhibit the appealing practice potential for achieving low-invasive, wireless, and battery-free neuromodulation. In this review, recent advances of physical cue-based strategies including electrical, acoustic, magnetic, and morphology for PNI are systematically overviewed, and the open challenges for realizing scalable clinical/commercial transformation and future perspectives of these strategies for PNI are concluded.

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Investigation of the effects of therapeutic ultrasound or photobiomodulation and the role of spinal glial cells in osteoarthritis-induced nociception in mice

Cited by 3 publications

References 42 publications

Observation on the Effect of MRI Image Scanning on Knee Pain in Football Injury

Observation on the Effect of MRI Image Scanning on Knee Pain in Football Injury

Synergistic effect of cannabidiol and transcutaneous electrical nerve stimulation on neuropathic and inflammatory pain in mice

Physical Cue‐Based Strategies on Peripheral Nerve Regeneration

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