Investigation of the effective interactions of two bioactive compounds in different media

Evaluation of solvent effect on the effective interactions of Isotretinoin and Tretinoin: Isomeric forms of vitamin A

“…Isotretinoin and Tretinoin as Vitamin A samples ( Table 1 ) were procured from Roche (Switzerland) and were used exactly as received. Moreover, solvents from Merck were employed along with their polarity characteristics [ 10 , 25 ] presented in Table 2 .…”

“…Researchers investigate solvent-induced effects using several solvent polarity parameters, such as dielectric constant and refractive index, in these systems. However, the nature and extent of different solvent–medication molecular interactions cannot be sufficiently explained by these single parameters [ [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] ].…”

“…Interactions between medications and their surrounding environment are vital in complex environments such as biological systems. The medications interact with environments like aqueous solution and molecules like proteins, where their active functional groups govern the type and intensity of interactions [ [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] ].…”

“…Solvatochromic parameters along with solvent polarity scales are typically used to evaluate the solvent effect on the interactional characteristics of medications. The approved techniques of solvent polarity scales, as developed by Kamlet–Abboud–Taft, can precisely predict the ideal solvent media for the solvation and possible interactions between medications and solvent media [ [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] ].…”