Investigation of the DGAT1 K232A and VNTR mutations in dairy and dual purpose cattle breeds

Scotti, Emilio; Schiavini, F.; Mattina, V. La; Davoli, Roberta; Russo, Vincenzo; Bagnato, A.

doi:10.4081/ijas.2007.1s.137

Cited by 4 publications

(8 citation statements)

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“…In this work we found a similar frequency of this allele in both the Friesian and the Jersey, merely because of the specific sampling of Friesian bulls with the higher and lower Genetic Merit for fat content. The true frequency of the allele coding for lysine is lower (0.25) in the Italian Holstein (Fontanesi et al, 2007). On the other hand, the frequency of this allele in the Jerseys of this study is 0.48, which is much lower than the 0.88 found in New Zealand Jerseys by Spelman et al (2002).…”

Section: Discussioncontrasting

confidence: 77%

“…This cannot be merely due to the limited sample of cows, that, on the contrary, showed a pretty high variability at the SCD1 and GHR SNPs. Also Fontanesi et al (2007) did not find this allele in the Valdostana breed (95 cows), and Kaupe et al (2004) indicate a frequency lower than 0.05 in the Piedmontese breed. The allele coding for lysine is referred to be the ancestral in cattle (Winter et al, 2002), but because it negatively affects milk yield, its frequency in dairy cattle is moderate to low .…”

Section: Discussionmentioning

confidence: 78%

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Exploring polymorphisms and effects on milk traits of the DGAT1, SCD1 and GHR genes in four cattle breeds

Signorelli¹,

Orrù²,

Napolitano³

et al. 2009

Livestock Science

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Section: Discussioncontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 78%

Exploring polymorphisms and effects on milk traits of the DGAT1, SCD1 and GHR genes in four cattle breeds

Signorelli¹,

Orrù²,

Napolitano³

et al. 2009

Livestock Science

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“…Based on the milk records, the mean 305-day milk yield (MY) was 4216.49 kg. This mean MY value is within the normal range compared with Chinese dual-purpose Sanhe cattle, Simental cattle, and Chinese Range Red cattle [27], but less than European dual-purpose Fleckvieh and Braunvieh breeds [26]. In our Xinjiang Brown population, mean milk fat percentage (FP) was 3.93%, similar to Fleckvieh and Braunvieh; mean milk protein percentage (PP) was 3.37%, higher than these two breeds [28].…”

Section: Resultsmentioning

confidence: 87%

“…Another study reported several SNPs associated with milk and functional traits in a population of the dual-purpose breed, Italian Simmental [22]. A few selection signature studies revealed several genetic variations in both dairy and beef cattle (Gir) populations [23, 24], and a few genetic polymorphism studies discussed the genetic architecture of milk production traits in the Italian Simmental breed [25, 26]. Despite the valuable information provided by these previous genomic studies, GWAS using high-density SNPs are still limited in dual-purpose breeds.…”

Section: Introductionmentioning

confidence: 99%

Genome-wide association study of milk and reproductive traits in dual-purpose Xinjiang Brown cattle

et al. 2019

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BackgroundDual-purpose cattle are more adaptive to environmental challenges than single-purpose dairy or beef cattle. Balance among milk, reproductive, and mastitis resistance traits in breeding programs is therefore more critical for dual-purpose cattle to increase net income and maintain well-being. With dual-purpose Xinjiang Brown cattle adapted to the Xinjiang Region in northwestern China, we conducted genome-wide association studies (GWAS) to dissect the genetic architecture related to milk, reproductive, and mastitis resistance traits. Phenotypic data were collected for 2410 individuals measured during 1995–2017. By adding another 445 ancestors, a total of 2855 related individuals were used to derive estimated breeding values for all individuals, including the 2410 individuals with phenotypes. Among phenotyped individuals, we genotyped 403 cows with the Illumina 150 K Bovine BeadChip.ResultsGWAS were conducted with the FarmCPU (Fixed and random model circulating probability unification) method. We identified 12 markers significantly associated with six of the 10 traits under the threshold of 5% after a Bonferroni multiple test correction. Seven of these SNPs were in QTL regions previously identified to be associated with related traits. One identified SNP, BovineHD1600006691, was significantly associated with both age at first service and age at first calving. This SNP directly overlapped a QTL previously reported to be associated with calving ease. Within 160 Kb upstream and downstream of each significant SNP identified, we speculated candidate genes based on functionality. Four of the SNPs were located within four candidate genes, including CDH2, which is linked to milk fat percentage, and GABRG2, which is associated with milk protein yield.ConclusionsThese findings are beneficial not only for breeding through marker-assisted selection, but also for genome editing underlying the related traits to enhance the overall performance of dual-purpose cattle.

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“…Different cattle breeds show highly variable frequencies of the mutation (Kaupe et al. 2004) and some dairy breeds are monomorphic (Fontanesi et al. 2007).…”

Section: Discussionmentioning

confidence: 99%

Ovine acyl CoA:diacylglycerol acyltransferase 1– molecular characterization, polymorphisms and association with milk traits

Scatà¹,

Napolitano²,

Casu

et al. 2009

Animal Genetics

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The objective of this work was to characterize the complete coding region of the ovine acylCoA:diacylglycerol acyltransferase 1 (DGAT1) gene of three Italian sheep breeds: Sarda, Altamurana and Gentile di Puglia. Characterization was accomplished by direct sequencing of 8676 bp of the relevant DNA, including introns and partial 5' and 3' untranslated regions (UTRs). We detected five novel SNPs; one SNP (g.5553C>T) is located in intron 2, has similar frequencies in the three breeds and showed a negative association with milk fat content. More interesting is an SNP in the 5' UTR (g.127C>A), the occurrence of which is rare in the higher milk-fat breeds (Altamurana and Gentile di Puglia); it is located in the core sequence of Sp1, a putative binding site of transcription factors. This SNP showed a significant negative association with milk fat content in the Sarda sheep. Because DGAT1 plays a fundamental role in triacylglycerol synthesis, the novel detected SNP in the 5' UTR of the DGAT1 gene might explain, at least partially, the variation of fat content in the milk of Sarda sheep.

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Investigation of the DGAT1 K232A and VNTR mutations in dairy and dual purpose cattle breeds

Cited by 4 publications

References 0 publications

Exploring polymorphisms and effects on milk traits of the DGAT1, SCD1 and GHR genes in four cattle breeds

Exploring polymorphisms and effects on milk traits of the DGAT1, SCD1 and GHR genes in four cattle breeds

Genome-wide association study of milk and reproductive traits in dual-purpose Xinjiang Brown cattle

Ovine acyl CoA:diacylglycerol acyltransferase 1– molecular characterization, polymorphisms and association with milk traits

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