Investigation of the Degree of Disorder of the Structure of Polymer Soft Contact Lenses Using Positron Annihilation Lifetime Spectroscopy PALS

Filipecki, J.; Kotynia, Katarzyna; Filipecka, Katarzyna

doi:10.17219/pim/62279

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…The structural investigation and defect analysis of soft contact lenses performed by PALS highlighted the lower degree of disorder in the hydrogel contact lenses due to their water-filled macropores compared to the silicone-hydrogel lenses. The geometry and nature of the defects completely differed due to the different preparation technologies applied for the lenses; hydrogel lenses exhibited more compact structures [ 101 ].…”

Section: Resultsmentioning

confidence: 99%

Positron Annihilation Lifetime Spectroscopy as a Special Technique for the Solid-State Characterization of Pharmaceutical Excipients, Drug Delivery Systems, and Medical Devices—A Systematic Review

et al. 2023

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The aims of this systematic review are to explore the possibilities of using the positron annihilation lifetime spectroscopy (PALS) method in the pharmaceutical industry and to examine the application of PALS as a supportive, predictive method during the research process. In addition, the review aims to provide a comprehensive picture of additional medical and pharmaceutical uses, as the application of the PALS test method is limited and not widely known in this sector. We collected the scientific literature of the last 20 years (2002–2022) from several databases (PubMed, Embase, SciFinder-n, and Google Scholar) and evaluated the data gathered in relation to the combination of three directives, namely, the utilization of the PALS method, the testing of solid systems, and their application in the medical and pharmaceutical fields. The application of the PALS method is discussed based on three large groups: substances, drug delivery systems, and medical devices, starting with simpler systems and moving to more complex ones. The results are discussed based on the functionality of the PALS method, via microstructural analysis, the tracking of ageing and microstructural changes during stability testing, the examination of the effects of excipients and external factors, and defect characterization, with a strong emphasis on the benefits of this technique. The review highlights the wide range of possible applications of the PALS method as a non-invasive analytical tool for examining microstructures and monitoring changes; it can be effectively applied in many fields, alone or with complementary testing methods.

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Section: Resultsmentioning

confidence: 99%

Positron Annihilation Lifetime Spectroscopy as a Special Technique for the Solid-State Characterization of Pharmaceutical Excipients, Drug Delivery Systems, and Medical Devices—A Systematic Review

et al. 2023

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“…In the case of time-dependent studies, annihilation parameters show changes in the physical and chemical aging/degradation of polymers, 31 in the post curing of the epoxy resin system, 32 as well as in the discontinuous investigation of cured processes ex situ. [33][34][35] For the rst time, in our work, the in situ time evolution of microstructural shrinkage during photopolymerization was shown by PALS technique and related to parallel NIR-photorheology measurements giving output on macrostructural changes. Also, the kinetics of photopolymerization were described via the free-volume concept.…”

Section: Introductionmentioning

confidence: 90%

In situinvestigation of the kinetics and microstructure during photopolymerization by positron annihilation technique and NIR-photorheology

et al. 2018

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Investigation of the Degree of Disorder of the Structure of Polymer Soft Contact Lenses Using Positron Annihilation Lifetime Spectroscopy PALS

Cited by 2 publications

References 13 publications

Positron Annihilation Lifetime Spectroscopy as a Special Technique for the Solid-State Characterization of Pharmaceutical Excipients, Drug Delivery Systems, and Medical Devices—A Systematic Review

Positron Annihilation Lifetime Spectroscopy as a Special Technique for the Solid-State Characterization of Pharmaceutical Excipients, Drug Delivery Systems, and Medical Devices—A Systematic Review

In situinvestigation of the kinetics and microstructure during photopolymerization by positron annihilation technique and NIR-photorheology

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