Investigation of the complex descending innervation of the dorsal cochlear nucleus in the rat: a transneuronal tract-tracing study using pseudorabies virus

Helfferich, Frigyes; Uhereczky, Gabriella; Boldogkői, Zsolt; Vitéz, Lajos Csokonai; Palkovits, Miklós

doi:10.1016/s0304-3940(02)01324-1

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…Corticofugal pathways that originate in ACx are postulated to provide tonotopically organized negative feedback that can modulate activity in the contralateral DCN. The ACx projects to the DCN via a direct pathway (Weedman and Ryugo, 1996) and potentially could project indirectly to the DCN via synaptic relays in the IC or other locations (Faye-Lund, 1985;Caicedo and Herbert, 1993;Herbert et al 1991;Malmierca, 1996;Saldana et al, 1996;Druga et al, 1997;Alibardi, 2002;Senatorov and Hu, 2002;Winer et al, 2002;Helfferich et al, 2003). There is also a corticofugal pathway, which can influence olivocochlear efferent activity and cochlear output (Zhongju and Suga, 2001).…”

Section: Effect Of Noise Exposure On 2dg-samentioning

confidence: 99%

“…There is also a corticofugal pathway, which can influence olivocochlear efferent activity and cochlear output (Zhongju and Suga, 2001). Crossed inhibitory connections function to transmit activity between the direct and indirect pathways and could include commissural projections between the cochlear nuclei (Buchwald and Humphrey, 1972a;Young and Brownell, 1976;Cant and Gaston, 1982;Wenthold, 1987;Shore et al, 1992;Schofield and Cant, 1996a,b;Joris and Smith, 1998;Babalian et al, 1999Babalian et al, , 2002Needham and Paolini, 2003;Helfferich et al, 2003) and inferior colliculi (Smith, 1992;Moore et al, 1998;Malmierca et al, 2003), and the crossed olivocochlear pathway (Liberman, 1989), among others. Figure 14B shows the relative levels of SA in the auditory pathway.…”

Section: Effect Of Noise Exposure On 2dg-samentioning

confidence: 99%

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Effect of unilateral noise exposure on the tonotopic distribution of spontaneous activity in the cochlear nucleus and inferior colliculus in the cortically intact and decorticate rat

Imig

Durham

2005

J of Comparative Neurology

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Effects of unilateral noise exposure on spontaneous activity (SA) in the anteroventral and dorsal cochlear nuclei (AVCN and DCN) and the central nucleus of the inferior colliculus (ICc) were studied in cortically intact and decorticate rats. SA was measured 1 week following exposure using uptake of 14C-labeled 2-deoxyglucose (2DG) in quiet. Optical density (OD) measurements were obtained in low- and high-frequency (LF and HF) areas of each nucleus. We refer to the ipsilateral AVCN and DCN (side of the noise-exposed ear) and the contralateral ICc as direct nuclei and to their opposite side counterparts as indirect nuclei. Noise exposure altered the tonotopic profile of SA in the direct pathway by causing a decrease in the ratio of HF OD to LF OD (HF/LF ratio). In intact animals, the decreased HF/LF ratio was due to decreased HF OD. In decorticate animals, it was due to decreased HF OD and increased LF OD, the latter occurring mainly in the DCN and ICc. Decorticate-intact differences may reflect corticofugal feedback inhibition. Lesion of the dorsal acoustic stria caused a substantial decrement of SA in the contralateral ICc. Furthermore, strong positive correlations between HF/LF ratios in the DCN, AVCN, and contralateral ICc suggest that the cochlear nucleus is a major contributor to SA in the ICc. Noise exposure had opposite and weaker effects on 2DG uptake in the indirect pathway that were attributed to crossed inhibition. Noise-induced changes in the tonotopic profile of SA may represent a neural correlate of tinnitus.

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Section: Effect Of Noise Exposure On 2dg-samentioning

confidence: 99%

Section: Effect Of Noise Exposure On 2dg-samentioning

confidence: 99%

Effect of unilateral noise exposure on the tonotopic distribution of spontaneous activity in the cochlear nucleus and inferior colliculus in the cortically intact and decorticate rat

Imig

Durham

2005

J of Comparative Neurology

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“…Unlike conventional tracers, PRV can label chains of synaptically linked neurons by retrograde transport of viral particles across synapses that link these neurons. Many studies have shown that PRV can invade axons and replicate, and then migrate in a retrograde fashion to transneuronally infect multisynaptic circuits in the brain (Boldogkoi, Bratincsak, & Fodor, 2002; Card, 2001; Helfferich, Uhereczky, Boldogkoi, Vitez, & Palkovits, 2003; Loewy, 1998; Sams, Jansen, Mettenleiter, & Loewy, 1995). …”

Section: Transneuronal Labeling Of Mem Reflex Pathways Using Pseudo-rmentioning

confidence: 99%

Auditory Brainstem Circuits That Mediate the Middle Ear Muscle Reflex

Mukerji

Windsor

Lee

2010

Trends in Amplification

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The middle ear muscle (MEM) reflex is one of two major descending systems to the auditory periphery. There are two middle ear muscles (MEMs): the stapedius and the tensor tympani. In man, the stapedius contracts in response to intense low frequency acoustic stimuli, exerting forces perpendicular to the stapes superstructure, increasing middle ear impedance and attenuating the intensity of sound energy reaching the inner ear (cochlea). The tensor tympani is believed to contract in response to self-generated noise (chewing, swallowing) and nonauditory stimuli. The MEM reflex pathways begin with sound presented to the ear. Transduction of sound occurs in the cochlea, resulting in an action potential that is transmitted along the auditory nerve to the cochlear nucleus in the brainstem (the first relay station for all ascending sound information originating in the ear). Unknown interneurons in the ventral cochlear nucleus project either directly or indirectly to MEM motoneurons located elsewhere in the brainstem. Motoneurons provide efferent innervation to the MEMs. Although the ascending and descending limbs of these reflex pathways have been well characterized, the identity of the reflex interneurons is not known, as are the source of modulatory inputs to these pathways. The aim of this article is to (a) provide an overview of MEM reflex anatomy and physiology, (b) present new data on MEM reflex anatomy and physiology from our laboratory and others, and (c) describe the clinical implications of our research.

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Investigation of the complex descending innervation of the dorsal cochlear nucleus in the rat: a transneuronal tract-tracing study using pseudorabies virus

Cited by 2 publications

References 17 publications

Effect of unilateral noise exposure on the tonotopic distribution of spontaneous activity in the cochlear nucleus and inferior colliculus in the cortically intact and decorticate rat

Effect of unilateral noise exposure on the tonotopic distribution of spontaneous activity in the cochlear nucleus and inferior colliculus in the cortically intact and decorticate rat

Auditory Brainstem Circuits That Mediate the Middle Ear Muscle Reflex

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