Investigation of the clinicopathological and prognostic role of circMTO1 in multiple cancers

Zhou, Jian; Qiu, Cheng; Tang, Xianzhe; Wan, Rongjun; Wu, Ziyi; Zou, Dazhi; Wang, Wanchun; Luo, Yuan

doi:10.1080/14737159.2023.2177102

Cited by 1 publication

(1 citation statement)

References 55 publications

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“…Indeed, one circRNA can adsorb several miRNAs, one miRNA molecule can target a wide range of different mRNAs with the involvement of corresponding protein products in the development of several pathologies, and individual circRNAs can be markers of several diseases simultaneously. Many circRNAs, in particular circMTO1, circHIPK3, сirc_0001946, circPTPRA, and circCOL1A1, are potential targets for therapy or biomarkers of CAD ( Table 1 and Table 2 ), and play critical roles in cancer progression as well [ 175 , 176 , 177 , 178 , 179 ]. Additional comprehensive studies of the action mechanisms of individual circRNAs and the involved regulatory networks are needed.…”

Section: Circrnas Are Promising Biomarkers and Therapeutic Targets Fo...mentioning

confidence: 99%

Circular RNAs Variously Participate in Coronary Atherogenesis

Dergunova,

Vinogradina,

Filippenkov

et al. 2023

CIMB

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Over the past decade, numerous studies have shown that circular RNAs (circRNAs) play a significant role in coronary artery atherogenesis and other cardiovascular diseases. They belong to the class of non-coding RNAs and arise as a result of non-canonical splicing of premature RNA, which results in the formation of closed single-stranded circRNA molecules that lack 5′-end caps and 3′-end poly(A) tails. circRNAs have broad post-transcriptional regulatory activity. Acting as a sponge for miRNAs, circRNAs compete with mRNAs for binding to miRNAs, acting as competing endogenous RNAs. Numerous circRNAs are involved in the circRNA–miRNA–mRNA regulatory axes associated with the pathogenesis of cardiomyopathy, chronic heart failure, hypertension, atherosclerosis, and coronary artery disease. Recent studies have shown that сirc_0001445, circ_0000345, circ_0093887, сircSmoc1-2, and circ_0003423 are involved in the pathogenesis of coronary artery disease (CAD) with an atheroprotective effect, while circ_0002984, circ_0029589, circ_0124644, circ_0091822, and circ_0050486 possess a proatherogenic effect. With their high resistance to endonucleases, circRNAs are promising diagnostic biomarkers and therapeutic targets. This review aims to provide updated information on the involvement of atherogenesis-related circRNAs in the pathogenesis of CAD. We also discuss the main modern approaches to detecting and studying circRNA–miRNA–mRNA interactions, as well as the prospects for using circRNAs as biomarkers and therapeutic targets for the treatment of cardiovascular diseases.

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