Investigation of the clinical efficacy of CGF and ozone in the management of alveolar osteitis: a randomized controlled trial

Torul, Damla; Ömezli, Mehmet Melih; Avci, Tolunay

doi:10.1007/s00784-023-05074-3

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…Ozone applications have yielded promising results in the treatment of inflammatory and immune-mediated conditions of oral soft tissues, such as oral lichen planus and aphthous stomatitis ( 32 , 33 ). In addition, ozone has been applied in the context of post-operative wounds and complications such as alveolar osteitis, which alleviated painful symptoms and reduced healing times ( 34 , 35 ). Additionally, ozone has generally contributed to a reduction of possible side effects associated with traditional treatments of these oral ulcerative conditions and surgical wounds and complications ( 33 , 34 , 36 ).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, ozone has been applied in the context of post-operative wounds and complications such as alveolar osteitis, which alleviated painful symptoms and reduced healing times ( 34 , 35 ). Additionally, ozone has generally contributed to a reduction of possible side effects associated with traditional treatments of these oral ulcerative conditions and surgical wounds and complications ( 33 , 34 , 36 ). Due to its antimicrobial activity, ozone has been reported to be useful in the management of oral disease of infectious etiology, such as herpetic stomatitis and oral candidiasis ( 37 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ozone therapy in dentistry: An overview of the biological mechanisms involved (Review)

Veneri,

Filippini,

Consolo

et al. 2024

Biomed Rep

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ozone therapy in dentistry: An overview of the biological mechanisms involved (Review)

Veneri,

Filippini,

Consolo

et al. 2024

Biomed Rep

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Efficacy of concentrated growth factor (CGF) in the surgical treatment of oral diseases: a systematic review and meta-analysis

Chen,

Cheng,

Cai

et al. 2023

BMC Oral Health

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Background Concentrated growth factor (CGF), a new autologous platelet concentrate, has been widely investigated to the adjunctive treatment of oral diseases. This study aims to evaluate the efficacy of CGF in the surgical treatment of oral diseases. Methods MEDLINE, Web of Science, Scopus, Cochrane, and EMBASE databases were searched up to July 2023. Only randomized clinical trials were included. The methodologic quality was evaluated by the Cochrane Risk of Bias Tool. RevMan 5.4 software was used for data analysis. Results In the treatment of periodontal intrabony defects, bone graft combined with CGF was significantly superior to bone graft (P < 0.01), with mean intrabony defect depth reduction of 1.41 mm and mean clinical attachment level gain of 0.55 mm. In the regenerative surgery of furcation defects, the effect of CGF group was significantly better than control group (P < 0.0001), with mean probing depth reduction of 0.99 mm, vertical bone gain of 0.25 mm, and horizontal bone gain of 0.34 mm. CGF combined with coronally advanced flap (CAF) was more effective than CAF alone (mean keratinized tissue width increase of 0.41 mm, mean gingival thickness increase of 0.26 mm, P < 0.00001), but less effective than connective tissue graft (CTG) combined with CAF (mean root coverage difference of -15.1%, mean gingival thickness difference of -0.5 mm, P < 0.0001). In the alveolar ridge preservation, additional use of CGF reduced horizontal bone resorption by 1.41 mm and buccal vertical bone resorption by 1.01 mm compared to control group (P < 0.0001). The VAS score of CGF group was significantly lower than that of the control group at the 1st and 7th day after oral surgery (P < 0.0001). Conclusions CGF can exert a positive adjunctive effect for the regenerative surgery of periodontal intrabony defects, furcation defects, and alveolar ridge preservation procedure. CGF combined with CAF has a better therapeutic effect on gingival recession compared to CAF alone, although it is not as effective as CTG combined with CAF. CGF could promote postoperative healing and pain relief in oral surgery within a week. There is currently not enough evidence to support the clinical benefits of CGF in other oral surgeries.

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Investigation of the clinical efficacy of CGF and ozone in the management of alveolar osteitis: a randomized controlled trial

Cited by 2 publications

References 24 publications

Ozone therapy in dentistry: An overview of the biological mechanisms involved (Review)

Ozone therapy in dentistry: An overview of the biological mechanisms involved (Review)

Efficacy of concentrated growth factor (CGF) in the surgical treatment of oral diseases: a systematic review and meta-analysis

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