Investigation of the chemical profile and anti-inflammatory mechanisms of flavonoids from Artemisia vestita Wall. ex Besser via targeted metabolomics, zebrafish model, and network pharmacology

Zhou, Chaoyi; Chen, Jing; Zhang, Huazheng; Zhang, Shanshan; Zhang, Yun; Liu, Kechun; Mi, Ma; Xia, Qing

doi:10.1016/j.jep.2022.115932

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…Metabolomics’ study of holistic metabolic properties in complex biological matrices is consistent with the holistic thinking of Chinese medicine and can be used to explore the pathological mechanisms of airway inflammation in pneumonia and the efficacy of Chinese medicines. 3 , 4 The application of metabolomics in the treatment of pneumonia with Chinese medicine has been reported, mainly in animal and human samples. 5 Animal models can partially simulate the pathological changes of pneumonia, but their species differences with humans pose many hidden dangers for clinical translation.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Zhixiao Tang on Anti-Inflammatory Multiple Targets and Multiple Components: Metabonomics Combined with Database Mining Technology

Zhang,

Li,

et al. 2024

JIR

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Section: Introductionmentioning

confidence: 99%

Mechanisms of Zhixiao Tang on Anti-Inflammatory Multiple Targets and Multiple Components: Metabonomics Combined with Database Mining Technology

Zhang,

Li,

et al. 2024

JIR

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“…This method avoids the destruction of the active ingredients by high temperatures. It also facilitates the dissolution and bio-transformation of the active ingredients (Zhou et al 2023 ). The semi-bionic extraction method has been chosen to study the physiological effects of complex digestive processes of food or drug (Yan et al 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Analysis of the chemical composition and biological activity of secondary residues of Turkish Gall treated by semi-bionic technology

Jiang

Zhang

Jiang

et al. 2023

Bioresour. Bioprocess.

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In order to meet the contemporary concept of sustainable development, the reuse of biological waste has also been emphasized. Lots of papers nowadays study the extraction of primary residues. The disposal of secondary residues is often neglected. The chemical composition and biological activity of secondary residues of Turkish Gall (SRTG) were researched in this paper. We selected five methods to extract the SRTG, and the extraction conditions were water, hydrochloric acid buffer (pH = 2), artificial gastric juice (pH = 2), phosphate buffer (pH = 6.8), and artificial intestinal solution (pH = 6.8). The changes of phenolic components were determined by spectrophotometry and high-performance liquid chromatography. The acid-base environment did not affect total polyphenols contents and gallic acid ethyl ester contents in SRTG. But it affected the gallic acid contents in SRTG. The contents of gallic acid in the hydrochloric acid buffer extraction groups were 1.63 times that of the water extraction group. The SRTG were extracted by hydrochloric acid buffer also had better inhibition on Escherichia coli and Staphylococcus aureus. In addition, SRTG showed positive effects on 1,1-Diphenyl-2-picrylhydrazyl Free, 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid), ·OH radicals, and Ferric ion reducing antioxidant power. Some active components of SRTG can be effectively released through the digestion of simulated gastric juices in vitro. The change of active ingredients affects the antibacterial and antioxidant capacity. The results provide data support for the conversion of secondary residues into products, such as feed additives. The SRTG has certain contributes to the value of the circular economy. Graphical Abstract

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Artemdubosides A-G, seven unusual polyacetylenes from Artemisia dubia var. subdigitata and their antihepatoma activity

Ke-Xin,

Yun-Bao,

Tian-Ze

et al. 2024

Fitoterapia

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Investigation of the chemical profile and anti-inflammatory mechanisms of flavonoids from Artemisia vestita Wall. ex Besser via targeted metabolomics, zebrafish model, and network pharmacology

Cited by 3 publications

References 40 publications

Mechanisms of Zhixiao Tang on Anti-Inflammatory Multiple Targets and Multiple Components: Metabonomics Combined with Database Mining Technology

Mechanisms of Zhixiao Tang on Anti-Inflammatory Multiple Targets and Multiple Components: Metabonomics Combined with Database Mining Technology

Analysis of the chemical composition and biological activity of secondary residues of Turkish Gall treated by semi-bionic technology

Artemdubosides A-G, seven unusual polyacetylenes from Artemisia dubia var. subdigitata and their antihepatoma activity

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