Investigation of the atrial electromechanical delay duration in Behcet patients by tissue Doppler echocardiography

Karabağ, Turgut; Aydın, Mustafa; Dogan, Sait Mesut; Koca, Rafet; Buyukuysal, Cagatay; Sayın, Muhammet Raşit; Yavuz, Nesimi

doi:10.1093/ejechocard/jer227

Cited by 21 publications

(19 citation statements)

References 31 publications

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“…compared the atrial conduction times measured by electrophysiolgical methods and tissue Doppler echocardiography, and reported that TDI could be used to evaluate atrial conduction times. Earlier studies revealed that atrial EMD obtained by this method was prolonged in various diseases such as type 1 DM, Behcet disease, familial Mediterranean fever, ankylosing spondylitis, scleroderma, and hypothyroidism …”

Section: Discussionmentioning

confidence: 99%

Evaluation of Atrial Electromechanical Delay and Diastolic Functions in Patients with Hyperthyroidism

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Evaluation of Atrial Electromechanical Delay and Diastolic Functions in Patients with Hyperthyroidism

et al. 2013

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“…Prevalence of cardiovascular involvement in BD has been reported as 7-29% [3]. Different cardiovascular manifestations such as acute myocardial infarction, endocarditis, myocarditis, pericarditis, valvular diseases, dilated cardiomyopathy, conduction system disturbances, and ventricular arrhythmias have been reported [5], albeit rarely. Different cardiovascular manifestations such as acute myocardial infarction, endocarditis, myocarditis, pericarditis, valvular diseases, dilated cardiomyopathy, conduction system disturbances, and ventricular arrhythmias have been reported [5], albeit rarely.…”

Section: Introductionmentioning

confidence: 99%

Assessment of QRS duration and presence of fragmented QRS in patients with Behçet’s disease

Sayın

Akpınar

Gürsoy

et al. 2013

Coronary Artery Disease

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“…Aktürk et al (21) found that LA mechanical functions and volumes were impaired in BD who have no clinical evidence for cardiovascular disease. In a study of Karabağ et al (22) atrial electromechanical delay (EMD) duration, a non-invasive predictor of AF, were investigated in patients with BD and interatrial and intra-atrial EMD found to be increased in patients with BD compared with the control group.…”

Section: Discussionmentioning

confidence: 99%

The effect of nebivolol on P wave duration and dispersion in patients with Behçet’s disease; a prospective single-arm controlled study

Akkaya¹,

Karakaş²,

Şahin³

et al. 2013

Anadolu Kardiyol Derg

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Objective: Behçet's disease (BD) is a chronic multi-system disease presenting with recurrent oral and genital ulceration, and relapsing uveitis. Left ventricular diastolic dysfunction, ventricular arrhythmia and sudden cardiac death have been documented in BD. P wave dispersion (PD) has been reported to be associated with inhomogeneous and discontinuous propagation of sinus impulses. PD has been reported to be longer in patients with BD. Nebivolol, besides its selective beta1-blocking activity, causes an endothelium dependent vasodilatation through nitric oxide release. In this study, we searched for the effects of nebivolol on P wave duration and dispersion in patients with BD. Methods: This study was designed as prospective single-arm controlled study. We prospectively studied 35 Behçet's patients who were diagnosed according to the International Study Group criteria. Patients received 5 mg nebivolol per day for 3 months. The patients were evaluated with 12-leads electrocardiography at baseline and after for 3-month therapy. The difference between maximum and minimum P wave durations was defined as PD. The paired samples t test, Wilcoxon test were used for statistical analysis. Results: A significant decrease was observed in PD after therapy period (62.85±21.62 vs. 44.28±18.03 msec, p=0.001). No adverse effects were observed in treatment period. Conclusion: BD is associated with prolonged P wave duration and dispersion. We have shown for the first time that nebivolol causes a significant decrease in maximum P wave duration and PD in patients with BD. However, further comprehensive studies are needed to determine the long-term effects of nebivolol. (Anadolu Kardiyol Derg 2013; 13: 682-7) Key words: Behçet's disease, nebivolol, P wave dispersion Original Investigation Özgün Araşt›rma 682ÖZET Amaç: Behçet hastalığı (BH), tekrarlayıcı oral ve genital ülserasyon ve üveit atakları ile karakterize, kronik multisistemik bir hastalıktır. BH'da sol ventrikül diyastolik disfonksiyonu, ventriküler aritmi ve ani kardiyak ölüm vakaları bildirilmiştir. P dalga dispersiyonu (PD)'nun, sinüs uyarılarının homojen olmayan ve kesintili yayılımı ile ilişkili olduğu gösterilmiştir. PD'nin BH'da daha uzun olduğu gösterilmiştir. Selektif beta 1 bloker olan nebivolol, nitrik oksit salınımı sayesinde endotel bağımlı vazodilatasyon yapar. Bu çalışmada, BH'da nebivololün P dalga süresi ve PD üzerinde-ki etkisini araştırdık. Yöntemler: Bu araştırma prospektif, tek grup kontrollü çalışma olarak tasarlandı. Çalışmaya Uluslararası Çalışma Grubu kriterlerine uyan 35 BH alındı. Hastalara 3 ay süreyle 5 mg/gün nebivolol verildi. Hastalar başlangıçta ve 3 aylık tedavi sonrasında 12 kanallı elektrokardiyografi ile değerlendirildi. Maksimum ve minimum P dalga süresi arasındaki fark PD olarak belirlendi. Paired samples t-test, Wilcoxon testi istatistiksel değerlendirme için kullanıldı. Bulgular: Tedavi sonrasında PD'da belirgin azalma izlendi (62.85±21.62'e karşı 44.28±18.03 msn, p=0.001). Tedavi süresinde herhangi bir yan etki izlenmedi. So...

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Investigation of the atrial electromechanical delay duration in Behcet patients by tissue Doppler echocardiography

Cited by 21 publications

References 31 publications

Evaluation of Atrial Electromechanical Delay and Diastolic Functions in Patients with Hyperthyroidism

Evaluation of Atrial Electromechanical Delay and Diastolic Functions in Patients with Hyperthyroidism

Assessment of QRS duration and presence of fragmented QRS in patients with Behçet’s disease

The effect of nebivolol on P wave duration and dispersion in patients with Behçet’s disease; a prospective single-arm controlled study

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