Investigation of the Association Between Dopamine D1 Receptor Gene Polymorphisms and Essential Hypertension in a Group of Turkish Subjects

Abstract

Dopamine has been shown to influence blood pressure by regulating renal sodium excretion through direct interaction with the dopamine receptors, especially with the Dopamine D1 receptor (DRD1). To better understand the role of polymorphisms in those effects, we investigated the association between two polymorphic sites in the DRD1 promoter region (A-48G, G-94A) and essential hypertension in the Turkish population. The DRD1 variants were genotyped by restriction fragment length polymorphism (RFLP) analysis. A total of 205 unrelated individuals were enrolled in the study. We found that genotype distributions and allele frequencies of the control and hypertensive subjects were very similar and did not show any significant difference with respect to blood pressure (BP) and hypertension. Contribution of the gene variances in BP or hypertension by sex differences and dependence on body mass index (BMI) were also evaluated. Distribution of genotypes and allele frequencies were found to be in line with previous reports. However, increments detected in hypertensive subjects were far from being statistically significant.

Asociación y efectos de interacción en los genes AGT, AGTR1, ACE, ADRB2, DRD1, ADD1, ADD2, ATP2B1, TBXA2R y PTGS2 sobre la hipertensión en población antioqueña

“…Se han llevado a cabo numerosos estudios genéticos sobre estos sistemas; sin embargo, los resultados han sido incongruentes entre poblaciones, lo que evidencia la heterogeneidad de la hipertensión arterial en su etiología genética en las poblaciones continentales (45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58).…”

Association between GRK4 and DRD1 gene polymorphisms and hypertension: a meta-analysis

“…After the removal of overlapping articles and those that did not meet the inclusion criteria, a total of 15 articles including 29 studies were finally included in our meta-analysis. 19 , 20 , 22 – 31 , 42 – 44 The main characteristics of the included studies were presented in Table 1 . For GRK4 gene, seven studies with 1,704 cases and 1,705 controls dealt with rs1801058, six studies with 1,598 cases and 1,611 controls dealt with rs2960306, and nine studies with 1,973 cases and 1,946 controls dealt with rs1024323.…”

Dopamine Receptor D1R and D3R and GRK4 Interaction in Hypertension

“…The increase in blood pressure and the development of hypertension in D 1 -/- [107] and D 3 -/-[105,106] mice show the importance of these genes in blood pressure regulation. However, polymorphisms in the non-coding region of the human D 1 R gene, DRD1, have been associated with a decrease [126,127], increase [128,129], or no effect on blood pressure [130,131]. Furthermore, there are no polymorphisms in the coding region of DRD3 [132,133] that are associated with human essential hypertension, except in one report among Hani Chinese.…”