Investigation of the Antiasthmatic Properties of Ethanol Extract of &lt;i&gt;Callophyllis japonica&lt;/i&gt; in Mice

Park, Won Sun; Lee, Kyung Soo; Chun, Jin Ho; Urm, Sang Hwa; Lee, Daesung; Lee, Da-Young; Park, Sae-Gwang; Seo, Su‐Kil; Heo, Soo‐Jin; Qian, Zhong‐Ji; Jung, Won‐Kyo; Choi, Il‐Whan

doi:10.4314/tjpr.v12i6.17

Cited by 2 publications

(2 citation statements)

References 35 publications

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“…The findings of this study suggest that CCEE suppressed the secretion of IgE by decreasing IL-4 cytokine level. This is similar to a previous study [42] in which the secretion of serum IgE was reduced through regulation of IL-4 cytokine level by application of an ethanol extract of red algae Callophyllis japonica to atopic-induced mice. It has been shown that CCEE alleviates the symptoms of AD by reducing the secretion of various inflammatory mediators from basophils and mast cells.…”

Section: The Ph Of Ccee (Tablesupporting

confidence: 91%

Atopic Dermatitis Inhibitory Effect of Chondria crassicaulis Ethanol Extract

Kang¹,

Ryu²,

Lee³

et al. 2022

IJPS

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This study investigated the effect of Chondria crassicaulis ethanol extract on degranulation of rat basophilic leukemia-2H3 cells and 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in Bagg Albino/c mice. General properties of Chondria crassicaulis (proximate analysis, total phenol and total flavonoid) were measured; moreover, beta-hexosaminidase release and cytotoxicity in rat basophilic leukemia-2H3 cells, severity of skin dermatitis, production of cytokines, and total immunoglobulin E content in an atopic dermatitis-like mouse model were estimated. Chondria crassicaulis ethanol extract decreased the secretion of beta-hexosaminidase without cytotoxicity in rat basophilic leukemia-2H3 cells and decreased the total immunoglobulin E content in serum. In addition, Chondria crassicaulis ethanol extract decreased the production of interleukin-4 and interleukin-5 in mouse splenocytes, whereas significantly increased the level of interferon gamma. Furthermore, Chondria crassicaulis ethanol extract alleviated skin lesions induced by atopic dermatitis without causing toxicity to mouse splenocytes. Therefore, the present study findings suggest that Chondria crassicaulis ethanol extract can relieve atopic dermatitis by regulating the activity of type 1 T helper and type 2 T helper cells that mediate cellular immune response and it can be used as an effective alternative therapy for atopic dermatitis.

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Section: The Ph Of Ccee (Tablesupporting

confidence: 91%

Atopic Dermatitis Inhibitory Effect of Chondria crassicaulis Ethanol Extract

Kang¹,

Ryu²,

Lee³

et al. 2022

IJPS

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“…Polyphenols are well-known potent biologically active agents, but their wide diversity and chemical complexity makes it challenging to correlate their inflammation potency in vitro with specific biological activity in vivo (Wang et al 2005, Chen et al 2007, Park et al 2007). In our previous study (Park et al 2013), the polyphenol content of CJE was determined to be 39.8 mg g -1 . However, low amounts of carbohydrate (1.2 mg g -1 ) were detected in the CJE.…”

Section: Effect Of Cje On Lps-induced Mapks Activationmentioning

confidence: 99%

Anti-inflammatory effect of polyphenol-rich extract from the red alga Callophyllis japonica in lipopolysaccharide-induced RAW 264.7 macrophages

Ryu¹,

Choi²,

Qian³

et al. 2014

ALGAE

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Despite the extensive literature on marine algae over the past few decades, a paucity of published research and studies exists on red algae. The purpose of this study was to evaluate the potential therapeutic properties of the ethanol extract of the red alga Callophyllis japonica against lipopolysaccharide (LPS)-stimulated macrophage inflammation. The C. japonica extract (CJE) significantly inhibited the nitric oxide (NO) production and the induced dose-dependent reduction of the protein and mRNA levels of inducible nitric oxide synthase and cyclooxygenase-2. Additionally, the CJE reduced the mRNA levels of inflammatory cytokines, including tumor necrosis factor-α, interleukin (IL)-1β, and IL-6. We investigated the mechanism by which the CJE inhibits NO by examining the level of mitogen-activated protein kinases (MAPKs) activation, which is an inflammation-induced signaling pathway in macrophages. The CJE significantly suppressed the LPS-induced phosphorylation of c-Jun N-terminal kinase, extracellular signal-regulated kinase and p38 MAPK. Taken together, the results of this study demonstrate that the CJE inhibits LPS-induced inflammation by blocking the MAPK pathway in macrophages.

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Investigation of the Antiasthmatic Properties of Ethanol Extract of <i>Callophyllis japonica</i> in Mice

Cited by 2 publications

References 35 publications

Atopic Dermatitis Inhibitory Effect of Chondria crassicaulis Ethanol Extract

Atopic Dermatitis Inhibitory Effect of Chondria crassicaulis Ethanol Extract

Anti-inflammatory effect of polyphenol-rich extract from the red alga Callophyllis japonica in lipopolysaccharide-induced RAW 264.7 macrophages

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