Investigation of the Anti-Prostate Cancer Properties of Marine-Derived Compounds

Fan, Meiqi; Nath, Asoke; Tang, Yujiao; Choi, Youngjin; Debnath, Trishna; Choi, Eun‐Ju; Kim, Eun-Kyung

doi:10.3390/md16050160

Cited by 32 publications

(20 citation statements)

References 55 publications

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“…Research into the anticancer properties of natural compounds is a rapidly growing area of science. Many different classes of natural compounds have demonstrated anticancer properties including many plant-based and marine-based extracts [ 23 , 24 , 25 , 26 , 27 ]. ASX is a marine-based ketocarotenoid that has potent antioxidant characteristics [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro

et al. 2018

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Astaxanthin (ASX) is a marine-based ketocarotenoid; an accessory pigment in plants in that it has many different potential functions. ASX is an antioxidant that is notably more potent than many other antioxidants. Antioxidants have anti-inflammatory and oxidative stress-reducing properties to potentially reduce the incidence of cancer or inhibit the expansion of tumor cells. In this study, we tested the hypothesis that ASX would inhibit proliferation and migration of breast cancer cells in vitro. We found that application of ASX significantly reduced proliferation rates and inhibited breast cancer cell migration compared to control normal breast epithelial cells. Based on these results, further investigation of the effects of ASX on not only breast cancer cells, but other forms of tumor cells, should be carried out.

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Section: Discussionmentioning

confidence: 99%

Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro

et al. 2018

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“…Haematococcuspluvialis is also a rich source of carotenoid. Astaxanthin (3,3′-dihydroxy-β, β′-carotene-4,4′-dione) a xanthophyll carotenoid has demonstrated antioxidants properties and efficient promotion of apoptosis in prostate cancer cell lines by inhibiting NF-kappa B [143]. Siphonaxanthin is a specific keto-carotenoid of siphonaceous green algae.…”

Section: Marine-derived Compounds: Inductors Of Apoptosismentioning

confidence: 99%

New Drugs from the Sea: Pro-Apoptotic Activity of Sponges and Algae Derived Compounds

2019

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Natural compounds derived from marine organisms exhibit a wide variety of biological activities. Over the last decades, a great interest has been focused on the anti-tumour role of sponges and algae that constitute the major source of these bioactive metabolites. A substantial number of chemically different structures from different species have demonstrated inhibition of tumour growth and progression by inducing apoptosis in several types of human cancer. The molecular mechanisms by which marine natural products activate apoptosis mainly include (1) a dysregulation of the mitochondrial pathway; (2) the activation of caspases; and/or (3) increase of death signals through transmembrane death receptors. This great variety of mechanisms of action may help to overcome the multitude of resistances exhibited by different tumour specimens. Therefore, products from marine organisms and their synthetic derivates might represent promising sources for new anticancer drugs, both as single agents or as co-adjuvants with other chemotherapeutics. This review will focus on some selected bioactive molecules from sponges and algae with pro-apoptotic potential in tumour cells.

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“…Marine soft corals are rich in biologically-active substances, and have been shown to exert anti-inflammatory, anti-fungal, anti-viral, anti-cancer, and cytotoxic activities [7,8,9,10]. Cembrane -type diterpene are common secondary metabolites of marine and terrestrial organisms, and cytotoxicity is one of the major characteristics of compounds of this type [11,12,13].…”

Section: Introductionmentioning

confidence: 99%

Flaccidoxide-13-Acetate-Induced Apoptosis in Human Bladder Cancer Cells is through Activation of p38/JNK, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress Regulated Pathway

Su²,

Dai

et al. 2019

Marine Drugs

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Flaccidoxide-13-acetate, an active compound isolated from cultured-type soft coral Sinularia gibberosa, has been shown to have inhibitory effects against invasion and cell migration of RT4 and T24 human bladder cancer cells. In our study, we used an 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT), colony formation assay, and flow cytometry to determine the mechanisms of the anti-tumor effect of flaccidoxide-13-acetate. The MTT and colony formation assays showed that the cytotoxic effect of flaccidoxide-13-acetate on T24 and RT4 cells was dose-dependent, and the number of colonies formed in the culture was reduced with increasing flaccidoxide-13-acetate concentration. Flow cytometry analysis revealed that flaccidoxide-13-acetate induced late apoptotic events in both cell lines. Additionally, we found that flaccidoxide-13-acetate treatment upregulated the expressions of cleaved caspase 3, cleaved caspase 9, Bax, and Bad, and down-regulated the expressions of Bcl-2, p-Bad, Bcl-x1, and Mcl-1. The results indicated that apoptotic events were mediated by mitochondrial dysfunction via the caspase-dependent pathway. Flaccidoxide-13-acetate also provoked endoplasmic reticulum (ER) stress and led to activation of the PERK-eIF2α-ATF6-CHOP pathway. Moreover, we examined the PI3K/AKT signal pathway, and found that the expressions of phosphorylated PI3K (p-PI3K) and AKT (p-AKT) were decreased with flaccidoxide-13-acetate concentrations. On the other hand, our results showed that the phosphorylated JNK and p38 were obviously activated. The results support the idea that flaccidoxide-13-acetate-induced apoptosis is mediated by mitochondrial dysfunction, ER stress, and activation of both the p38 and JNK pathways, and also relies on inhibition of PI3K/AKT signaling. These findings imply that flaccidoxide-13-acetate has potential in the development of chemotherapeutic agents for human bladder cancer.

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Investigation of the Anti-Prostate Cancer Properties of Marine-Derived Compounds

Cited by 32 publications

References 55 publications

Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro

Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro

New Drugs from the Sea: Pro-Apoptotic Activity of Sponges and Algae Derived Compounds

Flaccidoxide-13-Acetate-Induced Apoptosis in Human Bladder Cancer Cells is through Activation of p38/JNK, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress Regulated Pathway

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