Abstract:PurposeTo investigate reproducible surgical techniques to optimize the long-term safety of liquid crystal polymer (LCP)-based retinal prosthesis implantation.MethodsAn LCP-based retinal prosthesis is fabricated monolithically on a single-body LCP substrate with all components, including the package and electrode array. We implanted the electrode array into the suprachoroidal space and anchored the package and transition part to the sclera in rabbits (n = 11). The safety profile was assessed upon the completion… Show more
“…The thermoplasticity of LCP can be utilized to create a non-planar structure for conformation to target tissues by a simple thermoforming process, and to rapidly form a multilayered structure by stacking independently prepared LCP layers and thermally pressing them to bond together. The potential of LCP has been demonstrated in wide range of applications in neural engineering such as a miniaturized all-LCP retinal implant with an eye-conformable structure [125] as well as various shapes of neural electrode arrays for cortical [126,127], cochlear [128,129], intraocular [130,131,132], and peripheral applications [133,134,135].…”
The development of reliable long-term encapsulation technologies for implantable biomedical devices is of paramount importance for the safe and stable operation of implants in the body over a period of several decades. Conventional technologies based on titanium or ceramic packaging, however, are not suitable for encapsulating microfabricated devices due to their limited scalability, incompatibility with microfabrication processes, and difficulties with miniaturization. A variety of emerging materials have been proposed for encapsulation of microfabricated implants, including thin-film inorganic coatings of Al2O3, HfO2, SiO2, SiC, and diamond, as well as organic polymers of polyimide, parylene, liquid crystal polymer, silicone elastomer, SU-8, and cyclic olefin copolymer. While none of these materials have yet been proven to be as hermetic as conventional metal packages nor widely used in regulatory approved devices for chronic implantation, a number of studies have demonstrated promising outcomes on their long-term encapsulation performance through a multitude of fabrication and testing methodologies. The present review article aims to provide a comprehensive, up-to-date overview of the long-term encapsulation performance of these emerging materials with a specific focus on publications that have quantitatively estimated the lifetime of encapsulation technologies in aqueous environments.
“…The thermoplasticity of LCP can be utilized to create a non-planar structure for conformation to target tissues by a simple thermoforming process, and to rapidly form a multilayered structure by stacking independently prepared LCP layers and thermally pressing them to bond together. The potential of LCP has been demonstrated in wide range of applications in neural engineering such as a miniaturized all-LCP retinal implant with an eye-conformable structure [125] as well as various shapes of neural electrode arrays for cortical [126,127], cochlear [128,129], intraocular [130,131,132], and peripheral applications [133,134,135].…”
The development of reliable long-term encapsulation technologies for implantable biomedical devices is of paramount importance for the safe and stable operation of implants in the body over a period of several decades. Conventional technologies based on titanium or ceramic packaging, however, are not suitable for encapsulating microfabricated devices due to their limited scalability, incompatibility with microfabrication processes, and difficulties with miniaturization. A variety of emerging materials have been proposed for encapsulation of microfabricated implants, including thin-film inorganic coatings of Al2O3, HfO2, SiO2, SiC, and diamond, as well as organic polymers of polyimide, parylene, liquid crystal polymer, silicone elastomer, SU-8, and cyclic olefin copolymer. While none of these materials have yet been proven to be as hermetic as conventional metal packages nor widely used in regulatory approved devices for chronic implantation, a number of studies have demonstrated promising outcomes on their long-term encapsulation performance through a multitude of fabrication and testing methodologies. The present review article aims to provide a comprehensive, up-to-date overview of the long-term encapsulation performance of these emerging materials with a specific focus on publications that have quantitatively estimated the lifetime of encapsulation technologies in aqueous environments.
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