Investigation of ¹⁸F and ⁸⁹Zr Isotopes Self-Absorption and Dose Rate Parameters for PET Imaging

Abstract

This work concerns study of self-absorption factor (SAF) and dose rate constants of zirconium-89 (89Zr) for the purpose of radiation protection in positron emission tomography (PET) and to compare them with those of 18F-deoxyglucose (18F-FDG). We analyzed the emitted energy spectra by 18F and 89Zr through anthropomorphic phantom and calculated the absorbed energy using Monte Carlo method. The dose rate constants for both radionuclides were estimated with 2 different fluence-to-effective dose conversion coefficients. Our estimated SAF value of 0.65 for 18F agreed with the recommendation of the American Association of Physicists in Medicine (AAPM). The SAF for 89Zr was in the range of 0.61-0.66 depending on the biodistribution. Using the fluence-to-effective dose conversion coefficients recommended jointly by the American National Standards Institute and the American Nuclear Society (ANSI/ANS), the dose rate at 1 m from the patient for 18F was 0.143 μSv·MBq−1·hr−1, which is consistent with the AAPM recommendation, while that for 89Zr was 0.154 μSv·MBq−1·hr−1. With the conversion coefficients currently recommended by the International Committee on Radiological Protection (ICRP), the dose rate estimates were lowered by 2.8% and 2.6% for 89Zr and 18F, respectively. Also, we observed that the AAPM derived dose is an overestimation near the patient, compared to our simulations, which can be explained by the biodistribution nature and the assumption of the point source. Thus, we proposed new radiation protection factors for 89Zr radionuclide.

From Bench to Bedside: Patient-Oriented Radiopharmaceutical Development in Nuclear Medicine Based on the Example of [89Zr]Zr-PSMA-DFO

“…Alfuraih et al compared the measurements taken to those that would occur when using the routinely employed [ 18 F]F-deoxyglucose for PET scans. At a distance of 1 m from the patient, the authors measured a dose rate of 0.143 μSv MBq-1 h-1 for F-18 and of 0.154 μSv MBq-1 h-1 for Zr-89 [ 26 ].…”