Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking

Ghesquière‐Diérickx, Laura; Schlechter, Annika; Félix-Bautista, Renato; Gehrke, Tim; Echner, G.; Kelleter, Laurent; Martišíková, M.

doi:10.3389/fonc.2021.780221

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…Obtained results are depicted in the supplementary figures S2, S3 and S4 (stacks.iop.org/PMB/67/015008/mmedia) (Supplementary_figures.pdf), for primary protons, helium and carbon, respectively. The trend reported is in agreement with previous studies, showing a rather exponential decrease of the secondary fragments fluence when increasing the angle from the primary beam direction (Mairani et al 2010, Haettner et al 2013, Ghesquière-Diérickx et al 2021.…”

Section: Spread-out Bragg Peakssupporting

confidence: 93%

Assessment of secondary neutrons in particle therapy by Monte Carlo simulations

et al. 2022

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Objective: The purpose of this study is to estimate the energy and angular distribution of secondary neutrons inside a phantom in hadron therapy, which will support decisions on detector choice and experimental setup design for in-phantom secondary neutron measurements. Approach: Dedicated Monte Carlo simulations were implemented, considering clinically relevant energies of protons, helium and carbon ions. Since scored quantities can vary from different radiation transport models, the codes FLUKA, TOPAS and MCNP were used. The geometry of an active scanning beam delivery system for heavy ion treatment was implemented, and simulations of pristine and spread-out Bragg peaks were carried out. Previous studies, focused on specific ion types or single energies, are qualitatively in agreement with the obtained results. Main results: The secondary neutrons energy distributions present a continuous spectrum with two peaks, one centred on the thermal/epithermal region, and one on the high-energy region, with the most probable energy ranging from 19 MeV up to 240 MeV, depending on the ion type and its initial energy. The simulations show that the secondary neutron energies may exceed 400 MeV and, therefore, suitable neutron detectors for this energy range shall be needed. Additionally, the angular distribution of the low energy neutrons is quite isotropic, whereas the fast/relativistic neutrons are mainly scattered in the down-stream direction. Significance: It would be possible to minimize the influence of the heavy ions when measuring the neutron-generated recoil protons by selecting appropriate measurement positions within the phantom. Although there are discrepancies among the three Monte Carlo codes, the results agree qualitatively and in order of magnitude, being sufficient to support further investigations with the ultimate goal of mapping the secondary neutron doses both in- and out-of-field in hadrontherapy. The obtained secondary neutron spectra are available as supplementary material.

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Section: Spread-out Bragg Peakssupporting

confidence: 93%

Assessment of secondary neutrons in particle therapy by Monte Carlo simulations

et al. 2022

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Characterisation of a customised 4-chip Timepix3 module for charged-particle tracking

Kelleter,

Schmidt,

Subramanian

et al. 2024

Radiation Measurements

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An in-vivo treatment monitoring system for ion-beam radiotherapy based on 28 Timepix3 detectors

Kelleter,

Marek,

Echner

et al. 2024

Sci Rep

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Ion-beam radiotherapy is an advanced cancer treatment modality offering steep dose gradients and a high biological effectiveness. These gradients make the therapy vulnerable to patient-setup and anatomical changes between treatment fractions, which may go unnoticed. Charged fragments from nuclear interactions of the ion beam with the patient tissue may carry information about the treatment quality. Currently, the fragments escape the patient undetected. Inter-fractional in-vivo treatment monitoring based on these charged nuclear fragments could make ion-beam therapy safer and more efficient. We developed an ion-beam monitoring system based on 28 hybrid silicon pixel detectors (Timepix3) to measure the distribution of fragment origins in three dimensions. The system design choices as well as the ion-beam monitoring performance measurements are presented in this manuscript. A spatial resolution of $${{4}\,\hbox {mm}}$$ 4 mm along the beam axis was achieved for the measurement of individual fragment origins. Beam-range shifts of $${1.5}\,\hbox {mm}$$ 1.5 mm were identified in a clinically realistic treatment scenario with an anthropomorphic head phantom. The monitoring system is currently being used in a prospective clinical trial at the Heidelberg Ion Beam Therapy Centre for head-and-neck as well as central nervous system cancer patients.

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Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking

Cited by 4 publications

References 30 publications

Assessment of secondary neutrons in particle therapy by Monte Carlo simulations

Assessment of secondary neutrons in particle therapy by Monte Carlo simulations

Characterisation of a customised 4-chip Timepix3 module for charged-particle tracking

An in-vivo treatment monitoring system for ion-beam radiotherapy based on 28 Timepix3 detectors

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