Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection

Aloia, Amanda L.; Calvert, Julie K.; Clarke, Jennifer N.; Davies, Lorena T.; Helbig, Karla J.; Pitson, Stuart M.; Carr, Jillian M.

doi:10.1038/cti.2017.32

Cited by 10 publications

(8 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SK1 converts sphingosine to S1P, and when this is inhibited during DENV infection, although immune responses are largely unchanged, there are adaptive changes in IFNAR1 and IRF1 that compromise DENV-induced type I IFN responses (Aloia et al . 2017 ).…”

Section: The Role Of Lipid Signaling Mediators During a Viral Infectionmentioning

confidence: 99%

Lipid droplets and lipid mediators in viral infection and immunity

Monson

Trenerry

Laws

et al. 2021

FEMS Microbiology Reviews

Self Cite

View full text Add to dashboard Cite

Lipid droplets (LDs) contribute to key pathways important for the physiology and pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids, protein sequestration, removal of toxic lipids and cellular communication; however, recent advancements in the field show these organelles as essential for various cellular stress response mechanisms, including inflammation and immunity, with LDs acting as hubs that integrate metabolic and inflammatory processes. The accumulation of LDs has become a hallmark of infection, and is often thought to be virally driven; however, recent evidence is pointing to a role for the upregulation of LDs in the production of a successful immune response to viral infection. The fatty acids housed in LDs are also gaining interest due to the role that these lipid species play during viral infection, and their link to the synthesis of bioactive lipid mediators that have been found to have a very complex role in viral infection. This review explores the role of LDs and their subsequent lipid mediators during viral infections and poses a paradigm shift in thinking in the field, whereby LDs may play pivotal roles in protecting the host against viral infection.

show abstract

Section: The Role Of Lipid Signaling Mediators During a Viral Infectionmentioning

confidence: 99%

Lipid droplets and lipid mediators in viral infection and immunity

Monson

Trenerry

Laws

et al. 2021

FEMS Microbiology Reviews

Self Cite

View full text Add to dashboard Cite

show abstract

“…Viruses manipulate cellular signalling. Examples of viral exploitation of SphK/S1P are influenza [ 217 ], measles [ 213 ], hepatitis B [ 218 ], dengue virus [ 219 ], the respiratory syncytial virus (RSV), hepatitis B virus (HBV), and hepatitis C viruses (HCV) [ 220 ].…”

Section: Targeting Sphk/s1p/s1pr In Viral Infection and Alleviatiomentioning

confidence: 99%

Targeting the SphK-S1P-SIPR Pathway as a Potential Therapeutic Approach for COVID-19

McGowan

Haddadi

Nassif

et al. 2020

IJMS

View full text Add to dashboard Cite

The world is currently experiencing the worst health pandemic since the Spanish flu in 1918—the COVID-19 pandemic—caused by the coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic is the world’s third wake-up call this century. In 2003 and 2012, the world experienced two major coronavirus outbreaks, SARS-CoV-1 and Middle East Respiratory syndrome coronavirus (MERS-CoV), causing major respiratory tract infections. At present, there is neither a vaccine nor a cure for COVID-19. The severe COVID-19 symptoms of hyperinflammation, catastrophic damage to the vascular endothelium, thrombotic complications, septic shock, brain damage, acute disseminated encephalomyelitis (ADEM), and acute neurological and psychiatric complications are unprecedented. Many COVID-19 deaths result from the aftermath of hyperinflammatory complications, also referred to as the “cytokine storm syndrome”, endotheliitus and blood clotting, all with the potential to cause multiorgan dysfunction. The sphingolipid rheostat plays integral roles in viral replication, activation/modulation of the immune response, and importantly in maintaining vasculature integrity, with sphingosine 1 phosphate (S1P) and its cognate receptors (SIPRs: G-protein-coupled receptors) being key factors in vascular protection against endotheliitus. Hence, modulation of sphingosine kinase (SphK), S1P, and the S1P receptor pathway may provide significant beneficial effects towards counteracting the life-threatening, acute, and chronic complications associated with SARS-CoV-2 infection. This review provides a comprehensive overview of SARS-CoV-2 infection and disease, prospective vaccines, and current treatments. We then discuss the evidence supporting the targeting of SphK/S1P and S1P receptors in the repertoire of COVID-19 therapies to control viral replication and alleviate the known and emerging acute and chronic symptoms of COVID-19. Three clinical trials using FDA-approved sphingolipid-based drugs being repurposed and evaluated to help in alleviating COVID-19 symptoms are discussed.

show abstract

“…In addition to protein kinases, some lipid kinases have been targeted by antivirals. One example is sphingosine kinase 1, which affects replication of dengue virus (Aloia et al, 2017). Its activity can be determined by measuring the production of 32 P-labeled sphingosine-1phosphate from sphingosine and [γ 32 P]ATP (Clarke et al, 2016;Pitman et al, 2012).…”

Section: Kinasesmentioning

confidence: 99%

In vitro methods for testing antiviral drugs

Rumlová

Ruml

2018

Biotechnology Advances

View full text Add to dashboard Cite

Despite successful vaccination programs and effective treatments for some viral infections, humans are still losing the battle with viruses. Persisting human pandemics, emerging and re-emerging viruses, and evolution of drug-resistant strains impose continuous search for new antiviral drugs. A combination of detailed information about the molecular organization of viruses and progress in molecular biology and computer technologies has enabled rational antivirals design. Initial step in establishing efficacy of new antivirals is based on simple methods assessing inhibition of the intended target. We provide here an overview of biochemical and cell-based assays evaluating the activity of inhibitors of clinically important viruses.

show abstract

Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection

Cited by 10 publications

References 52 publications

Lipid droplets and lipid mediators in viral infection and immunity

Lipid droplets and lipid mediators in viral infection and immunity

Targeting the SphK-S1P-SIPR Pathway as a Potential Therapeutic Approach for COVID-19

In vitro methods for testing antiviral drugs

Contact Info

Product

Resources

About