Investigation of spectroscopic, thermal, and biological properties of FeII, CoII, ZnII, and RuII complexes derived from azo dye ligand

Turan, Nevin; Buldurun, Kenan; Adigüzel, Ragıp; Aras, Abdülmelik; Türkan, Fikret; Bursal, Ercan

doi:10.1016/j.molstruc.2021.130989

Cited by 23 publications

(26 citation statements)

References 39 publications

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“…The azo-dyes are very interesting organic compounds that have an azobenzene group, which under thermal or photo exposition might lead to cis-trans transformation. Compounds such as methyl orange, 2-[-2-(6-nitro benzothiazolyl)azo]- imidazole (NBTAI), HL1 [2-Hydroxy-3-((5-mercapto-1,3,4-thiadiazol-2-yl)diazenyl)-1-naphth aldehyde], HL2 [3-((1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1Hpyrazol-4-yl)diazenyl)-2-hydroxy-1-naphthaldehyde], 5-(quinoly-8-azo)pyrimidine-2,4,6-trione (L1) and 5-(quinoly-8-azo)-1,3-dimethylpyrimidine-2,4,6-trione (L2), 2-[2−(1-Hydroxy-4-Chloro phenyl) azo]- imidazole (HClPAI) create coloured complexes with many metal ions Co(II), Ni(II), Zn(II), Cd(II), Hg(II), Cr (III), Mn (II), Fe (III), Ru (II) and Pd(II) [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

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Tropaeolin OO as a Chemical Sensor for a Trace Amount of Pd(II) Ions Determination

et al. 2022

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The selective determination of metals in waste solutions is a very important aspect of the industry and environmental protection. Knowledge of the contents and composition of the waste can contribute to design an efficient process separation and recovery of valuable metals. The problematic issue is primarily the correct determination of metals with similar properties such as palladium and platinum. Thus this paper focuses on the development of a selective method that enables Pd(II) determination in the presence of Pt(IV) ions using the azo-dye tropaeolin OO (TR). For this purpose, the process of the metalorganic complex formation and Pd(II) ions determination were studied by using UV–Vis spectrophotometry under different conditions: solvents (water and B-R buffer), pH (2.09–6.09), temperature (20–60 °C), anions and cations concentrations. The formed metalorganic complex between Pd and tropaeolin OO allows for distinguishing Pd(II) ions from both platinum complexes, i.e. Pt(II), Pt(IV). Moreover, the proposed method can be applied to solutions containing both chloride and chlorate ions. The obtained characteristic spectrum with two maxima allows the determination of palladium even in the presence of other cations (Na, K, Mg, Zn, Co, Ni, Al) and changed concentrations of Pt(IV) ions. Furthermore, the developed spectrophotometric method for the Pd(II) ions determination using tropaeolin OO is characterized by high selectivity towards palladium ions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tropaeolin OO as a Chemical Sensor for a Trace Amount of Pd(II) Ions Determination

et al. 2022

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“…This event can be explained by the changing in the electron density of the PR as a result of complexation. [10,17] The new bands was appeared in the Co(II), Fe(II) and Zn(II) complexes at 840, 859 and 825 cm À 1 respectively, due to presence of coordinated water molecule. [21] Finally the spectra of metal complexes showed new bands at the range 569-539 cm À 1 and 472-461 cm À 1 due to presence of MÀ N and MÀ O bands except for Ru(II) complex.…”

Section: Discussionmentioning

confidence: 98%

“…[20] The À N=NÀ peak of ligand appeared at 1598 cm À 1 , which gets shifted to higher freqency values by 2-6 cm À 1 in all metal complexes. [10] Upon coordination, the electron density of N atom of À N=NÀ group gets altered to metal ions and this indicated the complexation of nitrogen atom to metal ions. The C=N stretching vibration bands that on the PR shown a shift by 3-7 cm À 1 in the Fe(II), Co(II) and Ru(II) complexes, and it was observed at low wave numbers (See exper.…”

Section: Discussionmentioning

confidence: 99%

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Synthesis and Characterization of Azo Dye Complexes as Potential Inhibitors of Acetylcholinesterase, Butyrylcholinesterase, and Glutathione S‐Transferase

et al. 2022

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In this study, several metal(II) complexes (Fe, Co, Zn, and Ru) of an azo dye ligand (ADL) that, apart from pyrazole ring (PR), include anisole having (−OCH3) group at the m‐substitue of the phenyl (L: (E)‐4‐((3‐methoxyphenyl)diazenyl)‐3‐methyl‐1H‐pyrazol‐5‐amine) were prepared, characterized, and the biological activity studies were carried out. The structures of complexes were identified by elemental analysis, FTIR, UV‐vis, mass spectra (Fe(II) and Co(II)), 1H‐13C NMR spectra, and TGA‐DTA. The azo ligand and its metal complexes were evaluated for their biological properties according to the enzyme inhibitory activities. The lowest Ki values of Co(II) complex against all three GST (19.48±2.17 μM), AChE (22.14±3.74 μM), and BChE (26.39±3.19 μM) enzymes were verified as the most effective enzyme inhibition. The biological activity results suggest that the obtained complexes have good potentials to be used in further analyses to explore new pharmaceutical agents.

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Piperazine derivatives with potent drug moiety as efficient acetylcholinesterase, butyrylcholinesterase, and glutathione S‐transferase inhibitors

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et al. 2022

J Biochem & Molecular Tox

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Cholinesterases catalyze the breakdown of the neurotransmitter acetylcholine (ACh), a naturally occurring neurotransmitter, into choline and acetic acid, allowing the nervous system to function properly. In the human body, cholinesterases come in two types, including acetylcholinesterase (AChE; E.C.3.1.1.7) and butyrylcholinesterase (BChE; E.C.3.1.1.8). Both cholinergic enzyme inhibitors are essential in the biochemical processes of the human body, notably in the brain. On the other hand, GSTs are found all across nature and are the principal Phase II detoxifying enzymes in eukaryotes and prokaryotes. Specific isozymes are identified as therapeutic targets because they are overexpressed in various malignancies and may have a role in the genesis of other diseases such as neurological disorders, multiple sclerosis, asthma, and especially cancer cell. Piperazine chemicals have a role in many biological processes and have fascinating pharmacological properties. As a result, therapeutically effective piperazine research is becoming more prominent. Half maximal inhibition concentrations (IC50) of piperazine derivatives were found in ranging of 4.59–6.48 µM for AChE, 4.85–8.35 µM for BChE, and 3.94‐8.66 µM for GST. Also, piperazine derivatives exhibited Ki values of 8.04 ± 5.73–61.94 ± 54.56, 0.24 ± 0.03–32.14 ± 16.20, and 7.73 ± 1.13–22.97 ± 9.10 µM toward AChE, BChE, and GST, respectively. Consequently, the inhibitory properties of the AChE/BChE and GST enzymes have been compared to Tacrine (for AChE and BChE) and Etacrynic acid (for GST).

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Investigation of spectroscopic, thermal, and biological properties of FeII, CoII, ZnII, and RuII complexes derived from azo dye ligand

Cited by 23 publications

References 39 publications

Tropaeolin OO as a Chemical Sensor for a Trace Amount of Pd(II) Ions Determination

Tropaeolin OO as a Chemical Sensor for a Trace Amount of Pd(II) Ions Determination

Synthesis and Characterization of Azo Dye Complexes as Potential Inhibitors of Acetylcholinesterase, Butyrylcholinesterase, and Glutathione S‐Transferase

Piperazine derivatives with potent drug moiety as efficient acetylcholinesterase, butyrylcholinesterase, and glutathione S‐transferase inhibitors

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