Investigation of Sol−Gel Transition in Pluronic F127/D<sub>2</sub>O Solutions Using a Combination of Small-Angle Neutron Scattering and Monte Carlo Simulation

Li, Yunqi; Shi, Tongfei; Sun, Zhaoyan; An, Lijia; Huang, Qingrong

doi:10.1021/jp066019r

Cited by 46 publications

(45 citation statements)

References 49 publications

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“…In this last case, it has been suggested that gelation results from the crowding of clusters of weakly sticking particles. Herein, since the micelles form stable aggregates with a short-range interparticle attractive interaction [20], we speculate that the formation of the gel is dominated by the formation of a percolated particle cluster, which is consistent with the view by SANS and simulation [21]. Mallamace et al [19] also suggested that the structural arrest, usually combining many features of gelation and glass transition [42], is related to the formation of a spanning cluster made of localized particles connected by bonds.…”

Section: Resultssupporting

confidence: 87%

“…They suggested the gelation is related to the presence of long-living clusters, while the glass transition is due to crowding of particles. The SANS and simulation results of the F127/D 2 O system suggest that the sol-gel transition is dominated by the formation of a percolated polymer network [21], while some researchers argue that the physical gelation is beyond percolation [22]. Thus there is a need to fully investigate the phase diagram of the copolymer close to gelation using different methods to get a better insight into the nature of physical gelation.…”

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confidence: 99%

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Phase diagram of the Pluronic L64–H2O micellar system from mechanical spectroscopy

Zhou

Wang

et al. 2011

Phys. Rev. E

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The linear viscoelastic properties of aqueous Pluronic L64 solutions have been investigated at high copolymer concentrations (25-62 wt%) using our modified low-frequency mechanical spectroscopy. The concentration-temperature phase diagram of the L64/H(2)O system was constructed by studying the evolution of the loss modulus and loss tangent as temperature is increased at a fixed frequency. A particular attention was focused on the dynamics approaching the beginning and ending points (39% and 60%) of the fusiform gel region in the phase diagram. The dynamics is found to have a similar viscoelastic behavior at the low and high concentrations, where a frequency scaling expected for a static percolated network is exhibited. Moreover, with increasing temperature, the system above the critical gel concentration undergoes a transition from a viscoelastic liquid to a solid gel through a percolated particle network. Therefore, our results suggest that the formation of the gel is dominated by the percolation of the particle clusters.

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Section: Resultssupporting

confidence: 87%

mentioning

confidence: 99%

Phase diagram of the Pluronic L64–H2O micellar system from mechanical spectroscopy

Zhou

Wang

et al. 2011

Phys. Rev. E

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“…Li et al 10 studied the gelation of the F127 water solution by SANS and the Monte Carlo simulation method, with the aim of clarifying the role of the solvent in the process. They confirmed that a fraction of the water is bonded with the polymer, and this fraction plays a significant role in the gelation, increasing the bond strength between the PEO segments in the micelle corona.…”

Section: State Of the Artmentioning

confidence: 99%

Investigation of Pluronic© F127–Water solutions phase transitions by DSC and dielectric spectroscopy

Barba

D’Amore

Grassi

et al. 2009

J of Applied Polymer Sci

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ABSTRACT:The water solutions of the block copolymers PEO n -PPO m -PEO n , known as pluronics, show a complex thermal behavior, since they are liquid at low temperature (5 C), and they can give soft gel when heated at body temperature (37 C). These properties are of great interest in biomedical applications. To properly design these applications, a prerequisite is the knowledge of the thermodynamics-how much-and of the kinetics-how fast-with which these transformations take place. In this work, solutions of F127 (the copolymer for which n ¼ 100 and m ¼ 65) were studied by varying the concentration and the temperature and analyzing their behavior when heated under several heating rates. The studies were performed by differential scanning calorimetry (DCS) and dielectric spectroscopy. The investigations carried out under equilibrium conditions allowed us to determine the thermodynamics of the phase transitions, whereas the investigations carried out under varying conditions allowed us to quantify the kinetics of the phase transitions. Empirical models were also proposed to describe both the thermodynamics and the kinetics observed.

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“…3 d), S9 and S10, are in a good agreement with the ones previously reported in the literature for concentrated solutions of the same polymer. 50,[64][65][66][67] We used the IGOR software to t the scattering, as it was found to capture the scattering features/peaks best. From the SANS analysis, we observed the presence of globular structures, as indicated by the tted power low value (P~3).…”

Section: Rheological Properties and Self-assembly Behaviourmentioning

confidence: 99%

Novel thermoresponsive polymer outperforming Pluronic® F127

Constantinou¹,

Nele²,

Doutch³

et al. 2020

Preprint

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Thermoresponsive polymers featuring the appropriate combination of structural characteristics, i.e. architecture, composition, and molar mass (MM), can form physically crosslinked networks in a solvent upon changes in temperature. This fascinating class of polymers finds utility in various sectors such as formulation science and tissue engineering. Here, we report a novel thermoresponsive triblock terpolymer which out-performs the most commonly used and commercially available thermoresponsive polymer, Poloxamer P407 (also known as Pluronic® F127) in terms of gelation concentration. Specifically, the in-house synthesised polymer forms gels at lower concentrations that is an advantage in biomedical applications. To elucidate the differences in their macroscale gelling behaviour, we investigate their micellization via differential scanning calorimetry, and their nanoscale self-assembly behaviour in detail by means of small-angle neutron scattering by simultaneously recording their rheological properties (Rheo-SANS). Two different gelation mechanisms for the two polymers are revealed and proposed. Ex vivo gelation study upon intracameral injections demonstrated excellent potential for its application to improve drug residence in the eye.

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Investigation of Sol−Gel Transition in Pluronic F127/D₂O Solutions Using a Combination of Small-Angle Neutron Scattering and Monte Carlo Simulation

Cited by 46 publications

References 49 publications

Phase diagram of the Pluronic L64–H2O micellar system from mechanical spectroscopy

Phase diagram of the Pluronic L64–H2O micellar system from mechanical spectroscopy

Investigation of Pluronic© F127–Water solutions phase transitions by DSC and dielectric spectroscopy

Novel thermoresponsive polymer outperforming Pluronic® F127

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Investigation of Sol−Gel Transition in Pluronic F127/D2O Solutions Using a Combination of Small-Angle Neutron Scattering and Monte Carlo Simulation

Cited by 46 publications

References 49 publications

Phase diagram of the Pluronic L64–H2O micellar system from mechanical spectroscopy

Phase diagram of the Pluronic L64–H2O micellar system from mechanical spectroscopy

Investigation of Pluronic© F127–Water solutions phase transitions by DSC and dielectric spectroscopy

Novel thermoresponsive polymer outperforming Pluronic® F127

Contact Info

Product

Resources

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Investigation of Sol−Gel Transition in Pluronic F127/D₂O Solutions Using a Combination of Small-Angle Neutron Scattering and Monte Carlo Simulation