Investigation of social and emotion information processing in temporal lobe epilepsy with ictal fear

Reynders, Hazel; Broks, Paul; Dickson, Jon M; Lee, Claire E.; Turpin, Graham

doi:10.1016/j.yebeh.2005.07.013

Cited by 61 publications

(56 citation statements)

References 38 publications

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“…The extent of this damage can be related to impairment of FER (Adolphs, 2001). Such results are inconsistent with previous evidence that the amygdala is implicated in the semiology of TLE, and a feature of several types of epilepsy such as TLE, FLE and IGE (Kullmann, 2011;Farrant et al, 2005;Reynders et al, 2005). Further, chronic TLE negatively impacts upon facial emotion recognition (Meletti et al, 2009).…”

Section: Findings From Main Experimentsmentioning

confidence: 70%

“…The trend towards participants with recent onset epilepsy scoring lower than participants with chronic epilepsy for FER accuracy suggests this might be a valuable line of enquiry in those with adulthood-onset of epilepsy. However, contradictory findings have suggested that age at onset of epilepsy is not a factor for impaired fear recognition in adults so clearly other factors have yet to be identified (Reynders., 2005). Meletti and colleagues demonstrated that chronic drug-resistant TLE may be a factor for FER (Meletti et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…There is substantial evidence associating epilepsy with emotion perception recognition impairments, especially in TLE and FLE, and may be a specific feature to FLE (Farrant et al, 2005;Reynders, Broks, Dickson, Lee, & Turpin, 2005). Reynders and colleagues found evidence of impaired fear emotion recognition, especially in TLE.…”

Section: Facial Emotional Recognition Taskmentioning

confidence: 99%

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Autistic characteristics in adults with epilepsy

Wakeford

Hinvest

Ring

et al. 2014

Epilepsy & Behavior

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Section: Findings From Main Experimentsmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Facial Emotional Recognition Taskmentioning

confidence: 99%

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Autistic characteristics in adults with epilepsy

Wakeford

Hinvest

Ring

et al. 2014

Epilepsy & Behavior

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“…Numerous patients reported the emotion of fear prior to seizures (2). Mesial temporal lobe epilepsy is commonly associated with ictal fear (3), and temporal lobectomy patients showed a general impairment in fear conditioning (4,5). However, the association between seizure-modulated fear and the underlying basics of neuronal mechanisms remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Increased stathmin expression strengthens fear conditioning in epileptic rats

et al. 2014

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Abstract. Patients with temporal lobe epilepsy have inexplicable fear attack as the aura. However, the underlying neural mechanisms of seizure-modulated fear are not clarified. Recent studies identified stathmin as one of the key controlling molecules in learning and innate fear. Stathmin binds to tubulin, inhibits microtubule assembly and promotes microtubule catastrophes. Therefore, stathmin is predicted to play a crucial role in the association of epilepsy seizures with fear conditioning. Firstly, a pilocarpine model of epilepsy in rats was established, and subsequently the fear condition training was performed. The epileptic rats with fear conditioning (epilepsy + fear) had a much longer freezing time compared to each single stimulus. The increased freezing levels revealed a significantly strengthened effect of the epileptic seizures on the learned fear of the tone-shock contextual. Subsequently, the stathmin expression was compared in the hippocampus, the amygdale, the insular cortex and the temporal lobe. The significant change of stathmin expression occurred in the insular and the hippocampus, but not in the amygdale. Stathmin expression and dendritic microtubule stability were compared between fear and epilepsy in rats. Epilepsy was found to strengthen the fear conditioning with increased expression of stathmin and a decrease in microtubule stability. Fear conditioning slightly increased the expression of stathmin, whereas epilepsy with fear conditioning increased it significantly in the hippocampus, insular cortex and hypothalamus. The phosphorylated stathmin slightly increased in the epilepsy with fear conditioning. The increased expression of stathmin was contrary to the decrease of the stathmin microtubule-associated protein (MAP2) and α-tubulin in the epileptic rats with fear conditioning in all three areas of the brain. The most significant change of the ratio of MAP2 and α-tubulin/stathmin occurred in the insular cortex and hippocampus. In conclusion, epilepsy can strengthen the fear conditioning with increased stathmin and decreased microtubule stability, particularly in the insular cortex and hippacampus. Therefore, the insular cortex may play a more important role between fear and epilepsy.

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“…4 Other studies have shown that patients with epilepsy have problems interpreting emotion and behavioural responses and this can affect social interaction. 5,6 Educational professionals with an awareness of these issues should be available to provide support and assistance to these young people.…”

Section: Epilepsy In Childhoodmentioning

confidence: 99%