Investigation of serum iris level and inflammatory markers in Fibromyalgia Syndrome

Abstract

OBJECTIVE:In the present study, we aimed to compare serum irisin levels in patients with fibromyalgia syndrome (FMS) and healthy control subjects and also investigate the relationship between irisin, disease activity and inflammation markers in patients.METHODS:A total of 84 women, including 48 patients who were diagnosed with FMS and 36 healthy controls, were included in this study. The demographic characteristics of the patients and control group were recorded. VAS for pain and the Fibromyalgia Impact Questionnaire for the assessment of the physical function of the patients, SF36 was used for quality of life, and accompanying Beck Depression Inventory to assess depression was used. Blood samples were taken for analysis that irisin, and inflammatory markers of the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), high-sensitivity C-reactive protein (hs-CRP) and neutrophil/lymphocyte ratio (NLO). Serum irisin levels were determined using the Enzyme-Linked Immunosorbent Assay (ELISA) method.RESULTS:Serum irisin level of the patients with FMS had no significant differences compared with the healthy control group. When we compared the values of ESR, CRP, hsCRP, NLO with FMS patients and healthy controls, there was no significant difference found between them (p>0.05). There was no significant correlation between inflammatory markers and level of serum irisin (p>0.05). In patients, there was no significant correlation between inflammatory markers and level of serum irisin (p>0.05).CONCLUSION:Irisin, which is a myokine, was determined to have no significant role in the pathogenesis of FMS. Irisin had no association with disease activity and inflammatory markers. Also, the inflammation hypothesis was not supported, which suggested in FMS.

The Influence of Pro-inflammatory Cytokines and Genetic Variants in the Development of Fibromyalgia: A Traditional Review

“…IL-1β's association with fibromyalgia pathophysiology has been the subject of both human and animal studies. The results of several studies have shown the presence of increased levels of IL-1β in patients diagnosed with fibromyalgia compared to controls, giving some support to this linkage [ 17 , 22 ]. One study demonstrated that using a low dose of naltrexone (an atypical anti-inflammatory drug) for eight weeks diminished the overall symptomatology of fibromyalgia by 18% and also showed a 15% reduction of related pain.…”

Whole-Body Vibration Training on Oxidative Stress Markers, Irisin Levels, and Body Composition in Women with Fibromyalgia: A Randomized Controlled Trial

“…Skeletal muscle secretes the hormone irisin in response to physical exercise; this hormone has been linked to several positive effects on energy metabolism. Irisin acts as a messenger in white adipose tissue, modifying its phenotype to beige adipocyte, enhancing adipocyte thermogenic capacity [57,58]. Evidence points to an association between irisin secretion rising with an improvement in glucose and insulin metabolism.…”