Investigation of semi-solid formulations for 3D printing of drugs after prolonged storage to mimic real-life applications

Aita, Ilias El; Breitkreutz, Jörg; Quodbach, Julian

doi:10.1016/j.ejps.2020.105266

Cited by 33 publications

(13 citation statements)

References 27 publications

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“…Furthermore, several other studies reported the use of SSE printing techniques to fabricate tablets [ 51 , 68 , 69 , 70 , 71 ], oral films [ 72 ], and scaffolds [ 73 ], illustrating that SSE is an excellent technique to fabricate thermosensitive drugs at a lower temperature.…”

Section: Resultsmentioning

confidence: 99%

3D Printing of Thermo-Sensitive Drugs

et al. 2021

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Three-dimensional (3D) printing is among the rapidly evolving technologies with applications in many sectors. The pharmaceutical industry is no exception, and the approval of the first 3D-printed tablet (Spiratam®) marked a revolution in the field. Several studies reported the fabrication of different dosage forms using a range of 3D printing techniques. Thermosensitive drugs compose a considerable segment of available medications in the market requiring strict temperature control during processing to ensure their efficacy and safety. Heating involved in some of the 3D printing technologies raises concerns regarding the feasibility of the techniques for printing thermolabile drugs. Studies reported that semi-solid extrusion (SSE) is the commonly used printing technique to fabricate thermosensitive drugs. Digital light processing (DLP), binder jetting (BJ), and stereolithography (SLA) can also be used for the fabrication of thermosensitive drugs as they do not involve heating elements. Nonetheless, degradation of some drugs by light source used in the techniques was reported. Interestingly, fused deposition modelling (FDM) coupled with filling techniques offered protection against thermal degradation. Concepts such as selection of low melting point polymers, adjustment of printing parameters, and coupling of more than one printing technique were exploited in printing thermosensitive drugs. This systematic review presents challenges, 3DP procedures, and future directions of 3D printing of thermo-sensitive formulations.

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Section: Resultsmentioning

confidence: 99%

3D Printing of Thermo-Sensitive Drugs

et al. 2021

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“…When the solvent evaporates due to pressure, the material solidifies. The higher the viscosity, the higher the resolution [ 118 , 119 ]. This technique has been widely used for the manufacture of drugs [ 120 , 121 , 122 , 123 ] and, to a lesser extent, to make polymer scaffolds [ 118 , 119 ].…”

Section: Discussionmentioning

confidence: 99%

“…The higher the viscosity, the higher the resolution [ 118 , 119 ]. This technique has been widely used for the manufacture of drugs [ 120 , 121 , 122 , 123 ] and, to a lesser extent, to make polymer scaffolds [ 118 , 119 ]. The same research group [ 124 , 125 , 126 ] developed the so-called PAM 2, in which they replaced constant pressure with a mechanical piston as the driving force.…”

Section: Discussionmentioning

confidence: 99%

Main 3D Manufacturing Techniques for Customized Bone Substitutes. A Systematic Review

et al. 2021

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Clinicians should be aware of the main methods and materials to face the challenge of bone shortage by manufacturing customized grafts, in order to repair defects. This study aims to carry out a bibliographic review of the existing methods to manufacture customized bone scaffolds through 3D technology and to identify their current situation based on the published papers. A literature search was carried out using “3D scaffold”, “bone regeneration”, “robocasting” and “3D printing” as descriptors. This search strategy was performed on PubMed (MEDLINE), Scopus and Cochrane Library, but also by hand search in relevant journals and throughout the selected papers. All the papers focusing on techniques for manufacturing customized bone scaffolds were reviewed. The 62 articles identified described 14 techniques (4 subtraction + 10 addition techniques). Scaffold fabrication techniques can be also be classified according to the time at which they are developed, into Conventional techniques and Solid Freeform Fabrication techniques. The conventional techniques are unable to control the architecture of the pore and the pore interconnection. However, current Solid Freeform Fabrication techniques allow individualizing and generating complex geometries of porosity. To conclude, currently SLA (Stereolithography), Robocasting and FDM (Fused deposition modeling) are promising options in customized bone regeneration.

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“…The analysis indicated that drying process yielded 3D printed tablet (F2) of minimal water contents (<0.5%). While this approach offers advantages over using highly diluted drug and additive slurry [25,27,28] and producing relatively solid structure before any additional drying process, the elevated processing temperature might be less suitable for thermally labile drug. DSC thermographs indicated that onset of melting points of sorbitol, lactose and mannitol of 91, 140 and 164 o C respectively [37].…”

Section: A2-d2)mentioning

confidence: 99%

“…While the former obviates the need of engineering and stabilising filaments, it faces a major challenge of extruding a material into solidifying structures in acceptable time. The extrusion of semi-solids (drug suspension) at room temperature can be employed using a printer often used in tissue engineering [10,[25][26][27]. The process involves the use of powder slurry in a significant amount of water [25,27,28] or ethanol [29].…”

Section: Introductionmentioning

confidence: 99%

Temperature and solvent facilitated extrusion based 3D printing for pharmaceuticals

Dores

Kuźmińska

Soares

et al. 2020

European Journal of Pharmaceutical Sciences

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On demand manufacturing of patient-specific oral doses provides significant advantages to patients and healthcare staff. Several 3D printing (3DP) technologies have been proposed as a potential digital alternative to conventional manufacturing of oral tablets. For additive manufacturing approach to be successful for on-demand preparation, a facile process with minimal preparation steps and training requirements is needed. A novel hybrid approach to the 3D printing process is demonstrated here based on combined solvent and heating elements/factors/aspects to facilitate extrusion. The system employed a moderate elevated temperature range of (65-100 o C), a brief drying period, and a simple set-up. In this approach, a compact powder cylinder is used as a pharmaceutical ink to be extruded in a temperaturecontrolled metal syringe. The process proved compatible with hygroscopic polymers [Poly(vinyl alcohol (PVA) and poly(vinyl pyridine) (PVP)] and a number of pharmaceutical fillers (lactose, sorbitol and mannitol). The fabricated tablets demonstrated compendial acceptable weight and content uniformity as well as mechanical resistance. In vitro drug release of theophylline from 3D printed tablets was dependant on the nature of the polymer and its molecular weight. This reported approach offers significant advantages compared to other 3DP technologies: simplification of pre-product, the use of a moderate temperature range, a minimal drying period, and avoiding the use of mechanically complicated direct extruder machinery. In the future, we envisage the use of this low-cost and facile approach to fabricate small batches of bespoke tablets.

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Investigation of semi-solid formulations for 3D printing of drugs after prolonged storage to mimic real-life applications

Cited by 33 publications

References 27 publications

3D Printing of Thermo-Sensitive Drugs

3D Printing of Thermo-Sensitive Drugs

Main 3D Manufacturing Techniques for Customized Bone Substitutes. A Systematic Review

Temperature and solvent facilitated extrusion based 3D printing for pharmaceuticals

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