Investigation of self-reported chronic urticaria among adults in grasslands of northern China

Abstract

The clinical epidemiological characteristics of chronic urticaria (CU) in different populations were not completely consistent, and the epidemiological characteristics of CU were very complex. At present, there were some patient-based studies on CU, but few natural population-based studied in the world. This study aimed to analysis the prevalence of self-reported CU among adults in grasslands of northern China and its closely related factors. A multistage and proportionately stratified random sampling with a field interviewer-administered survey study was performed together with skin prick tests (SPT) and measurements of the daily pollen count. A total of 3406 subjects completed the study. The prevalence of self-reported CU was 5.61% (n = 191), which was higher in women than that of men (6.91% vs 4.08%, X2 = 12.785, P < .001). Seasonal or seasonal aggravation CU accounted for 110 (57.59%) patients. Pollen dispersal season was basically consistent with the peak season of CU, but there was no significant difference in the positive rate of pollen SPT between CU with seasonal or seasonal aggravation symptom and CU with free of symptom (X 2 = 0.425, P = .51), as well as between CU with seasonal or seasonal aggravation symptom and perennial CU (X 2 = 0.439, P = .51). Eczema (odds ratio [OR] = 2.807, P < .001), chronic diarrhea (OR = 2.486, P < .01), food allergy history (OR = 1.890, P < .01), history of family allergy (OR = 1.800, P < .001), and conjunctivitis (OR = 1.749, P < .01) were closely related to CU. This investigation provided the factors closely related to CU, and provided certain ideas for further research on the etiology and prevention of CU.

Risk of Atopic Disorders in Patients with Chronic Urticaria: A Systematic Review and Meta-Analysis

“…CU was specified as CSU/CIU in 17 studies [9, 24, 29, 31, 33, 34, 39, 42, 43, 45-47, 49-52, 54] and CIndU in 4 studies [18, 20, 27, 53]. Fourteen studies retrieved information on atopic disorders through medical charts/records [20, 21, 23, 27, 30, 32, 33, 35, 38, 42, 43, 50, 52, 53], 8 by questionnaire/self-report [18, 19, 31, 37, 40, 46, 47, 51], 7 by a physician diagnosis [9, 29, 34, 36, 41, 48, 49], and 9 did not describe their source of information [22, 24-26, 28, 39, 44, 45, 54]. All studies, but one, reported point prevalences of atopic disorders in CU, and six studies reported ORs.…”

“…For adult subjects only, the point prevalence ranged between 2 and 30% and the pooled point prevalence was estimated to 14% (9–21%, I 2 = 95%) (online suppl. S2b) [9, 19, 21, 22, 26, 28, 37, 41, 43, 51]. One study did not provide any quantitative data but found subjects with CU to have a significantly lower risk of a personal history of asthma and rhinitis compared to the general population.…”

“…For adult subjects only, the point prevalence ranged 3–59% and the pooled point prevalence was estimated to 22% (13–35%, I 2 = 99%) (online suppl. S2c) [9, 19, 21-23, 26, 28, 37, 41, 43, 51].…”

“…Thirty-four studies reported a point prevalence of asthma in CU [9, 19‒24, 26, 28‒32, 34‒54]. Point prevalence ranged 2–47%, and the pooled point prevalence was estimated to 12% (9–15%, I 2 = 100%) (Fig.…”

“…Details of the included studies are described in Table 1. The geographical distribution was as follows: 13 were conducted in Europe [9,[18][19][20][21][22][23][24][25][26][27][28][29], 11 in Asia [30][31][32][33][34][35][36][37][38][39][40], 10 in the Middle East (including Turkey) [41][42][43][44][45][46][47][48][49][50], 3 in North America [51][52][53], and 1 in South America [54]. Study designs consisted mostly of CS and cohort studies, although data on atopic diseases in CU were primarily presented in a CS manner.…”