Investigation of selective induction of Korean red ginseng extract on cytochrome P450 2D and 3A

Abstract

Ginseng (Panax ginseng Meyer) has been used as a traditional herbal drug in Asian countries. In this study, herb‐drug interaction (HDI) of Korean red ginseng (KRG) extract was investigated using in vitro and in vivo models. Male 5‐week‐old C54BL/6N mice were administered orally with KRG (0, 0.5, 1, and 2 g/kg) once a day for 2 and 4 weeks. The activities of 5 CYP enzymes were determined by monitoring the concentration of probes in blood by using cocktail assay. CYP2D‐catalyzed dextromethorphan O‐demethylation was found to be significantly induced after repeated administration of KRG. The AUCratio of probe for CYP2D decreased with the elevation of the dose and duration of KRG administration. Contrarily, AUCratio of probe for CYP3A increased on increasing the dose and duration of KRG administration. Similarly, CYP3A‐catalyzed midazolam 1′‐hydroxylation also increased in dose‐dependent manner in vitro. Herein, we suggested the possibility of KRG‐induced drug interaction upon continuous administration for 2 – 4 weeks.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.