Investigation of selected respiratory effects of (dex)medetomidine in healthy Beagles

Pleyers, Tekla; Levionnois, Olivier; Siegenthaler, Joëlle; Spadavecchia, Claudia; Raillard, Mathieu

doi:10.1016/j.vaa.2020.05.001

Cited by 9 publications

(15 citation statements)

References 6 publications

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“…A parallel study evaluating selected respiratory effects of medetomidine and dexmedetomidine using electrical impedance tomography (EIT) was also carried out at the same time (data reported elsewhere [ 27 ]). Absence of interference between EIT and NWR recordings was confirmed by manufacturers of both devices and during the experiment.…”

Section: Methodsmentioning

confidence: 99%

“…Heart rate (HR, beats minute −1 ), respiratory rate ( f R, breaths minute −1 ) and temperature (T, °C) were measured (thorax auscultation and rectal thermometer) and recorded every 10 min. Thoracic impedance was continuously recorded by electrical impedance tomography (Swisstom BB2, Swisstom AG, Switzerland) [ 27 ]. Blood samples (2 mL) were obtained from the left IV catheter into EDTA collection tubes at 2, 4, 8, 16, 30, 60, 90, 120 and 180 min after T 0 for future pharmacokinetic analysis (not performed yet).…”

Section: Methodsmentioning

confidence: 99%

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Effect of Medetomidine, Dexmedetomidine, and Their Reversal with Atipamezole on the Nociceptive Withdrawal Reflex in Beagles

Siegenthaler

Pleyers

Raillard

et al. 2020

Animals

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The objectives were: (1) to compare the antinociceptive activity of dexmedetomidine and medetomidine, and (2) to investigate its modulation by atipamezole. This prospective, randomized, blinded experimental trial was carried out on eight beagles. During the first session, dogs received either medetomidine (MED) (0.02 mg kg−1 intravenously (IV)] or dexmedetomidine (DEX) [0.01 mg kg−1 IV), followed by either atipamezole (ATI) (0.1 mg kg−1) or an equivalent volume of saline (SAL) administered intramuscularly 45 min later. The opposite treatments were administered in a second session 10–14 days later. The nociceptive withdrawal reflex (NWR) threshold was determined using a continuous tracking approach. Sedation was scored (0 to 21) every 10 min. Both drugs (MED and DEX) increased the NWR thresholds significantly up to 5.0 (3.7–5.9) and 4.4 (3.9–4.8) times the baseline (p = 0.547), at seven (3–11) and six (4–9) minutes (p = 0.938), respectively. Sedation scores were not different between MED and DEX during the first 45 min (15 (12–17), p = 0.67). Atipamezole antagonized sedation within 25 (15–25) minutes (p = 0.008) and antinociception within five (3–6) minutes (p = 0.008). Following atipamezole, additional analgesics may be needed to maintain pain relief.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Effect of Medetomidine, Dexmedetomidine, and Their Reversal with Atipamezole on the Nociceptive Withdrawal Reflex in Beagles

Siegenthaler

Pleyers

Raillard

et al. 2020

Animals

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“…Doses mais altas induzem elevação da pressão arterial mais duradoura, enquanto doses mais baixas, como a usada no estudo (0,5 µg/kg), os efeitos centrais predominam e induz-se a redução da pressão arterial. Pleyers et al (2020) observaram, em um estudo utilizando 8 cães, redução da frequência respiratória 10 minutos após administração via intravenosa, dexmedetomidina (10 µg/kg) ou medetomidina (20 µg/kg). Segundo Dart (1999) a combinação de alfa-2 agonistas com outros sedativos, tranquilizantes ou anestésicos pode resultar na potencialização dos efeitos cardiorrespiratórios.…”

Section: Discussionunclassified

Avaliação eletrocardiográfica e grau de sedação em cães submetidos à pré-anestesia com dexmedetomidina-metadona ou dexmedetomidina-midazolam / Electrocardiographic evaluation and degree of sedation in dogs submitted to pre-anesthesia with dexmedetomidine-methadone or dexmedetomidine-midazolam

Lima¹,

Batalha²,

Castillo³

et al. 2022

Braz. J. Anim. Environ. Res.

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O presente estudo teve como objetivo comparar os efeitos de dois protocolos pré-anestésicos sobre os parâmetros fisiológicos, eletrocardiográficos e o grau de sedação em cadelas que seriam submetidas a ovário-salpingo-histerectomia. Vinte animais foram divididos de forma randomizada em dois grupos (n=10) de acordo com o protocolo empregado, grupo 1 (G1: dexmedetomidina + metadona) e grupo 2 (G2: dexmedetomidina + midazolam). Foram coletados dados (frequência cardíaca e respiratória; pressão arterial sistólica; eletrocardiograma) antes (tempo 0) e após 15 minutos da aplicação intramuscular dos fármacos (tempo 15), sendo nesse último realizada a avaliação do grau de sedação. Notou-se uma redução significativa nos valores da pressão arterial sistólica (G1; p=0,002) e das frequências cardíaca (G1; p=0,0003 e G2; p0,0001) e respiratória (G2; p=0,034). Não foi notada diferença entre os protocolos empregados no que se refere à incidência de arritmias cardíacas nos animais, porém as mesmas foram notadas em aproximadamente 80% dos animais de ambos os grupos, sendo a mais frequente a parada sinusal, seguida dos bloqueios atrioventriculares (1º e 2º grau) e da bradiarritmia sinusal. Não houve diferença significativa no grau de sedação entre os grupos (p=0,969) e ambos protocolos induziram boa sedação (mediana ≥ 9; score máximo = 15). Conclui-se que a dexmedetomidina associada à metadona (G1) ou ao midazolam (G2) induziu, de maneira indistinta, arritmias cardíacas na maioria dos animais avaliados nesse estudo, bem como, alterações significativas nos parâmetros fisiológicos analisados (frequências cardíaca e respiratória e pressão arterial sistólica), apesar de promover um grau de sedação desejável em ambos protocolos empregados.

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“…Respiratory rate measurement has been described in horses (10,22,43) and dogs (45). Heart rate measurement has been validated in horses against pulse rate derived from arterial blood pressure waveform recorded simultaneously (41).…”

Section: Ratesmentioning

confidence: 99%

Thoracic Electrical Impedance Tomography—The 2022 Veterinary Consensus Statement

et al. 2022

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Electrical impedance tomography (EIT) is a non-invasive real-time non-ionising imaging modality that has many applications. Since the first recorded use in 1978, the technology has become more widely used especially in human adult and neonatal critical care monitoring. Recently, there has been an increase in research on thoracic EIT in veterinary medicine. Real-time imaging of the thorax allows evaluation of ventilation distribution in anesthetised and conscious animals. As the technology becomes recognised in the veterinary community there is a need to standardize approaches to data collection, analysis, interpretation and nomenclature, ensuring comparison and repeatability between researchers and studies. A group of nineteen veterinarians and two biomedical engineers experienced in veterinary EIT were consulted and contributed to the preparation of this statement. The aim of this consensus is to provide an introduction to this imaging modality, to highlight clinical relevance and to include recommendations on how to effectively use thoracic EIT in veterinary species. Based on this, the consensus statement aims to address the need for a streamlined approach to veterinary thoracic EIT and includes: an introduction to the use of EIT in veterinary species, the technical background to creation of the functional images, a consensus from all contributing authors on the practical application and use of the technology, descriptions and interpretation of current available variables including appropriate statistical analysis, nomenclature recommended for consistency and future developments in thoracic EIT. The information provided in this consensus statement may benefit researchers and clinicians working within the field of veterinary thoracic EIT. We endeavor to inform future users of the benefits of this imaging modality and provide opportunities to further explore applications of this technology with regards to perfusion imaging and pathology diagnosis.

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Investigation of selected respiratory effects of (dex)medetomidine in healthy Beagles

Cited by 9 publications

References 6 publications

Effect of Medetomidine, Dexmedetomidine, and Their Reversal with Atipamezole on the Nociceptive Withdrawal Reflex in Beagles

Effect of Medetomidine, Dexmedetomidine, and Their Reversal with Atipamezole on the Nociceptive Withdrawal Reflex in Beagles

Thoracic Electrical Impedance Tomography—The 2022 Veterinary Consensus Statement

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