Investigation of Schwann cell behaviour on RGD-functionalised bioabsorbable nanocomposite for peripheral nerve regeneration

Sedaghati, Tina; Jell, Gavin; Seifalian, Alexander M.

doi:10.1016/j.nbt.2014.01.002

Cited by 32 publications

(26 citation statements)

References 37 publications

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“…Also, a significant number of in vivo studies on collagen conduits showed good functional outcomes in nerve reconstructions in rat, cat, dog and primate models [113][114][115]. Researchers and surgeons have, however, raised their concern about these conduits due to its high cost, conduit stiffness, lack of flexibility and poor enhancement of nerve regeneration [116,117]. Also, collagen conduit application on major peripheral nerve injuries is limited to median and ulnar nerve repairs at the wrist and only observed as an alternative to the classic epineural suture repair [78].…”

Section: Collagenmentioning

confidence: 99%

“…The combination of POSS and PCL has been employed in the fabrication of peripheral nerve conduits and in vivo clinical studies to show the potential translation into clinics [117].…”

Section: Polyhedral Oligomeric Silsesquioxanementioning

confidence: 99%

“…With that intend, new peptides have been engineered to mimic the active binding domains of various extracellular matrix molecules [177,178]. Coating with arginylglycylaspartic acid (RGD) sequences (the tripeptide Arg-Gly-Asp) also obtained very good results [117,[179][180][181][182]. Structure pore design is a great strategy to promote nerve regeneration.…”

Section: Conduits Structure Modulationmentioning

confidence: 99%

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Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Pedrosa¹,

Caseiro²,

Santos³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Human adult peripheral nerve injuries are a high incidence clinical problem that greatly affects patients' quality of life. Although peripheral nervous system has intrinsic regenerative capacity, this occurs in an incomplete or poorly functional manner. When a nerve fiber loses its continuity with consequent damage of the basal lamina tubes, axon spontaneous regeneration is disorganized and mismatched. These phenomena translate in an inadequate nerve functional recovery and consequent musculoskeletal incapacity. Nerve grafts still remain the gold standard in peripheral injuries treatment. However, this approach contains its disadvantages such as the necessity of primary surgery to harvest the autografts, loss of a functional nerve, donor site morbidity and longer surgery procedures. Therefore, biomaterials and tissue engineering can provide efficient resources and alternatives to nerve injury repair not only by the development of biocompatible structures but also, introducing neurotrophic factors and cellular systems to stimulate optimum clinical outcome. In this chapter, a comprehensive state-of-the art picture of tissue-engineered nerve grafts scaffolds, their application in nerve regeneration along with latest advances in peripheral nerve repair and future perspectives will be discussed, including our own large experience in this field of knowledge.

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Section: Collagenmentioning

confidence: 99%

“…The combination of POSS and PCL has been employed in the fabrication of peripheral nerve conduits and in vivo clinical studies to show the potential translation into clinics [117].…”

Section: Polyhedral Oligomeric Silsesquioxanementioning

confidence: 99%

Section: Conduits Structure Modulationmentioning

confidence: 99%

See 1 more Smart Citation

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Pedrosa¹,

Caseiro²,

Santos³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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show abstract

“…Син-тез RGD-содержащей биомолекулы (лауриновая кислота-глицин-аргинин-глицин-аспарагиновая кислота-глицин-аминокапроновая кислота (LA-GRGDG-AHex) выполнен по методу, описанно-му ранее Sedaghati с соавт. [8]. RGD-пептиды были растворены до концентрации 0,2 мг/мл в фосфатно-солевом буфере (ФСБ), содержащем 0,05% Tween-20.…”

Section: материалы и методыunclassified

Modification by RGD-Peptides of Vascular Grafts of Small Diameter From Polyparolactone: Experimental Study Results

Матвеева¹,

Антонова²,

Sevost'yanova³

et al. 2017

Kompleks. probl. serdečno-sosud. zabol.

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“…This polymer platform, polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane, has been studied in animal models [99], and is currently undergoing clinical trials. We are also actively exploring the use of a biodegradable version, polyhedral oligomeric silsesquioxane polycaprolactone, for tissue-engineering purposes including vascular grafts [100][101][102].…”

Section: Titaniummentioning

confidence: 99%

Tissue engineering vascular grafts a fortiori: looking back and going forward

Natasha

Tan

Gundogan

et al. 2014

Expert Opinion on Biological Therapy

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Investigation of Schwann cell behaviour on RGD-functionalised bioabsorbable nanocomposite for peripheral nerve regeneration

Cited by 32 publications

References 37 publications

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Modification by RGD-Peptides of Vascular Grafts of Small Diameter From Polyparolactone: Experimental Study Results

Tissue engineering vascular grafts a fortiori: looking back and going forward

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