Investigation of ROS scavenging properties and in vitro cytotoxicity of oxygen-deficient La2O3-x nanostructure synthesized by spray pyrolysis method

Rehman, Yaser; Copet, Corentin; Morlando, Alexander; Huang, Xu‐Feng; Konstantinov, Konstantin

doi:10.1007/s40097-020-00356-8

Cited by 19 publications

(12 citation statements)

References 60 publications

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“…A LaO terminated surface neutralizes the hydroxyl radical ( • OH), whereas the electron-deficient surface neutralizes the superoxide radical (O 2 – ) during the scavenging assay: The La 3+ ion in La 2 O 3 further reacts with OH – to yield La(OH) 3 and subsequently a reverse reaction of La(OH) 3 with OH – to yield La 2 O 3 (eqs and ). The reverse reaction (La(OH) 3 into La 2 O 3 ) is pH dependent. , The effect of pH on ROS scavenging by oxygen deficient La 2 O 3– x is reported in our earlier work …”

Section: Resultsmentioning

confidence: 63%

“…The reverse reaction (La(OH) 3 into La 2 O 3 ) is pH dependent. 18,36 The effect of pH on ROS scavenging by oxygen deficient La 2 O 3−x is reported in our earlier work. 18 La 3OH La(OH)…”

mentioning

confidence: 75%

“…18,36 The effect of pH on ROS scavenging by oxygen deficient La 2 O 3−x is reported in our earlier work. 18 La 3OH La(OH)…”

mentioning

confidence: 75%

“…Lanthanum oxide (La 2 O 3 )-based NPs are already employed in therapeutic, magnetic, and fluorescent imaging in the field of biomedicine. , A range of fascinating physical and chemical properties of lanthanide oxides such as UV absorption, redox switching, high oxygen storage and releasing capacity, and magnetic/fluorescent characteristics stem from their special electronic configuration (4f shielded electrons). , …”

Section: Introductionmentioning

confidence: 99%

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Defect-Rich La₂O₃ Nanoparticles with Antioxidant Activity for Human Keratinocytes

Rehman

Morlando

Borras

et al. 2021

ACS Appl. Nano Mater.

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A deficiency in the human antioxidant system to scavenge free radicals results in mounting oxidative stress, causing various pathological conditions including immune system constraints. To support an underperforming antioxidant system and regulate homeostatic function, efficient and biocompatible reactive oxygen species (ROS) scavengers may be employed. At present, metal oxide-based antioxidants nanoparticles are of fundamental interest because of their smart surface property tailoring. A spray precipitation method was employed in this work to develop a strained and defect rich lanthanum oxide (La 2 O 3 ) nanostructure. A contraction in d-spacing and distortion in planes and vacancies were observed in the nanostructure, causing microstrain as verified by the William-Hall uniform deformation model (UDM). Photocatalytic activity was evaluated against commercial La 2 O 3 and Evonik Aeroxide TiO 2 P25 via dye degradation experiments. A 30% degradation reduction confirmed the ability of the nanostructure to scavenge free radicals generated by P25 upon ultraviolet (UV) irradiation. Compared to the commercial La 2 O 3 , the nanostructured La 2 O 3 showed an increase in UV absorption (200−400) nm due to a decrease in the optical band gap. A positive surface charge of the nanoparticles was observed from zeta potential measurements, suggesting sufficient colloidal stability. In vitro toxicity studies toward the nonmalignant human keratinocyte cell line (HaCaT) over a 24 h treatment period with the La 2 O 3 nanoparticles exhibited no toxicity in comparison with the control and ZnO nanoparticles. The antioxidant properties of the nanoparticles were investigated by a dichlorofluorescein (DCF)-based assay which revealed a decrease in intracellular ROS in comparison with Nacetylcysteine (NAC) and H 2 O 2 . In addition, confocal microscopy imaging showed the internalization of the nanoparticles and subsequent DCF intensity change between the treated and untreated cells, as supported by flow cytometry analysis. Our findings suggest that defect-rich La 2 O 3 nanoparticles could be used effectively as active inorganic UV filter and fluorescent contrast agent owing to their biocompatible antioxidant properties.

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Section: Resultsmentioning

confidence: 63%

“…The reverse reaction (La(OH) 3 into La 2 O 3 ) is pH dependent. 18,36 The effect of pH on ROS scavenging by oxygen deficient La 2 O 3−x is reported in our earlier work. 18 La 3OH La(OH)…”

mentioning

confidence: 75%

“…18,36 The effect of pH on ROS scavenging by oxygen deficient La 2 O 3−x is reported in our earlier work. 18 La 3OH La(OH)…”

mentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Defect-Rich La₂O₃ Nanoparticles with Antioxidant Activity for Human Keratinocytes

Rehman

Morlando

Borras

et al. 2021

ACS Appl. Nano Mater.

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“…Smoke obtained for B25 ranged from 8 to 34% from zero loads to maximum load of 4.4 kW, whereas for diesel smoke emissions ranged from 9 to 45% from low load to maximum load. Because biodiesel provides more fuel-borne oxygen, which promotes oxidation, the smoke obtained for B25 is lower than diesel at peak load [39][40][41][42]. At peak load, the smoke produced by diesel and B25 is 45 and 34%, respectively.…”

Section: Smoke Opacitymentioning

confidence: 99%

Combustion, Performance, and Emission Behaviors of Biodiesel Fueled Diesel Engine with the Impact of Alumina Nanoparticle as an Additive

Kumar¹,

Rajan

Mohanavel

et al. 2021

Sustainability

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The objective of this research work is to evaluate the performance, combustion, and exhaust emissions of a variable compression ratio diesel engine utilizing diesel 25% rubber seed biodiesel mixture (B25) blended with 25 ppm and 50 ppm of alumina nanoparticle running with different operating conditions. An ultrasonicator was used to make uniform dispersion of alumina (Al) nanoparticles in the diesel–biodiesel mixture. Biodiesel mixture blended with nanoparticles has physicochemical characteristics that are comparable to ASTM (American Society for Testing and Materials) D6751 limitations. The results revealed that the B25 exhibited a lower cylinder peak pressure and lower HRR (heat release rate) than diesel at maximum power. BTE (brake thermal efficiency) of B25 is 2.2% lower than diesel, whereas BSFC of B25 is increased by 6% in contrast to diesel. Emissions of HC (hydrocarbon), CO (carbon monoxide), and smoke for B25 were diminished, while emissions of NOx (nitrogen oxide) were higher at maximum power. Further, the combustion and performance of diesel engine were improved with the inclusion of alumina nanoparticles to biodiesel blends. In comparison to B25, BTE of B25 with 50% alumina nanoparticles (B25Al50) mixture was enhanced by 4.8%, and the BSFC was diminished by 8.5%, while HC, CO, and smoke were also diminished by 36%, 20%, and 44%, respectively. At peak load, the maximum cylinder pressure and HRR of B25 were improved by 4.2% and 6.7%, respectively, with the presence of 50% alumina nanoparticles in a biodiesel blend (B25Al50).

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Oxygen‐Deficient Bioceramics: Combination of Diagnosis, Therapy, and Regeneration

et al. 2023

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The journey of ceramics in medicine has been synchronized with an evolution from the first generation—alumina, zirconia, etc.—to the third —3D scaffolds. There is an up‐and‐coming member called oxygen‐deficient or colored bioceramics, which have recently found their way through biomedical applications. The oxygen vacancy steers the light absorption toward visible and near infrared regions, making the colored bioceramics multifunctional—therapeutic, diagnostic, and regenerative. Oxygen‐deficient bioceramics are capable of turning light into heat and reactive oxygen species for photothermal and photodynamic therapies, respectively, and concomitantly yield infrared and photoacoustic images. Different types of oxygen‐deficient bioceramics have been recently developed through various synthesis routes. Some of them like TiO2−x, MoO3−x, and WOx have been more investigated for biomedical applications, whereas the rest have yet to be scrutinized. The most prominent advantage of these bioceramics over the other biomaterials is their multifunctionality endowed with a change in the microstructure. There are some challenges ahead of this category discussed at the end of the present review. By shedding light on this recently born bioceramics subcategory, it is believed that the field will undergo a big step further as these platforms are naturally multifunctional.

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Investigation of ROS scavenging properties and in vitro cytotoxicity of oxygen-deficient La2O3-x nanostructure synthesized by spray pyrolysis method

Cited by 19 publications

References 60 publications

Defect-Rich La₂O₃ Nanoparticles with Antioxidant Activity for Human Keratinocytes

Defect-Rich La₂O₃ Nanoparticles with Antioxidant Activity for Human Keratinocytes

Combustion, Performance, and Emission Behaviors of Biodiesel Fueled Diesel Engine with the Impact of Alumina Nanoparticle as an Additive

Oxygen‐Deficient Bioceramics: Combination of Diagnosis, Therapy, and Regeneration

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Investigation of ROS scavenging properties and in vitro cytotoxicity of oxygen-deficient La2O3-x nanostructure synthesized by spray pyrolysis method

Cited by 19 publications

References 60 publications

Defect-Rich La2O3 Nanoparticles with Antioxidant Activity for Human Keratinocytes

Defect-Rich La2O3 Nanoparticles with Antioxidant Activity for Human Keratinocytes

Combustion, Performance, and Emission Behaviors of Biodiesel Fueled Diesel Engine with the Impact of Alumina Nanoparticle as an Additive

Oxygen‐Deficient Bioceramics: Combination of Diagnosis, Therapy, and Regeneration

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Defect-Rich La₂O₃ Nanoparticles with Antioxidant Activity for Human Keratinocytes

Defect-Rich La₂O₃ Nanoparticles with Antioxidant Activity for Human Keratinocytes