Investigation of relapse rate and factors affecting relapse after oral isotretinoin treatment in patients with acne vulgaris

Saadet, Elif Demirci

doi:10.1111/dth.15109

Cited by 7 publications

(8 citation statements)

References 34 publications

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“…The results of the present study found that the majority of participants used treatment until the disappearance of acne, as compared to participants who used treatment until the drug was finished. The previous study supports the findings by stating that most people prefer to use treatment until the acne disappears completely (Elif, 2021). Where by continuing medication was not so common among individuals showing that people discontinue their treatment as they see improvement in their skin.…”

Section: Discussionsupporting

confidence: 82%

Self-medication for acne among medical students on different academic levels in Riyadh, KSA 2022-2023

Abdullah¹,

AM²,

Alanazi³

et al. 2023

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The choice and application of medications by individuals to treat diseases or symptoms that they have recognized or diagnosed for themselves are selfmedication. Due to the nature of medical education about acne treatment and the easy availability of acne medication, medical students are the most variable for self-medication. Objectives: Our study aims to demonstrate selfmedication for acne among medical students on different academic level.

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Section: Discussionsupporting

confidence: 82%

Self-medication for acne among medical students on different academic levels in Riyadh, KSA 2022-2023

Abdullah¹,

AM²,

Alanazi³

et al. 2023

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“…A comparable relapse rate had been reported in the literature. 19,30 In a Turkish study, the relapse rate was found to be 37.3%. 30 Significant variability in the rates of acne relapse among patients using OI had been reported; the rate ranges between 10% and 60%.…”

Section: Discussionmentioning

confidence: 99%

“…19,30 In a Turkish study, the relapse rate was found to be 37.3%. 30 Significant variability in the rates of acne relapse among patients using OI had been reported; the rate ranges between 10% and 60%. 16 In a previous study, 69.5% of patients relapsed within 2 years after completing OI course.…”

Section: Discussionmentioning

confidence: 99%

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Acne Vulgaris Relapse in Sudanese Patients Treated with Oral Isotretinoin: Rate and Predictive Factors

Ibrahim¹,

Osman²,

Awaad³

et al. 2023

JMDH

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Purpose Acne vulgaris is a skin disorder primarily affecting teenagers and young adults. Acne relapse is the main drawback of oral isotretinoin (OI), which is the golden therapy for severe acne. This study aimed to assess the rate and predictive factors of acne relapse among Sudanese patients using OI. Patients and Methods A cross-sectional study was conducted in a dermatology and venereology clinic-Sudan, using a self-administered questionnaire and data collection sheet. Patients using OI for acne treatment were enrolled in the study. Chi-square test and logistic regression analysis were used to evaluate the association between variables. P-value <0.05 was considered statistically significant. Results 225 acne patients (mean age: 26.0±4.2 years, females: 88.9%) were included in this study. OI daily dose ranged from 0.25 to 1 mg/kg/day, with frequent daily doses of 40–49 mg (57.3%) over 3–6 months (81.8%). Around one-third of patients (36%) received maintenance therapy after completion of OI course. At a 2-year follow-up, approximately 36% of patients experienced acne relapse that commonly occurred within 6–18 months after the last OI therapy. Early discontinuation of OI was a positive predictor of acne relapse which was 3.99 times greater in patients who had early discontinued OI than those completing the planned OI course (OR=3.99; p =0.002). OI cumulative doses of 120–139 mg/kg and 140–159 mg/kg were negative predictors of acne relapse (OR=0.23; p =0.001 and OR=0.15; p =0.02, respectively). Most patients (94.2%) received prescription OI, and 76.4% of women were advised to use contraceptives. About 69% of patients practiced skin care. Conclusion About one-third of patients experienced acne relapse. Early discontinuation and low cumulative doses of OI are the main risk factors for acne relapse. Long-term therapy of OI, with cumulative doses of 120–159 mg/kg, would be beneficial to reduce acne relapse.

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“…Other reported adverse events are headache, intracranial hypertension, depression, myalgias, arthralgias, and teratogenicity (Jones et al, 1983;Hull and Demkiw-Bartel, 2000). A transient clinical worsening of acne occurring in 6% of patients has also been reported, during the first month of treatment (Demirci Saadet, 2021).…”

Section: Introductionmentioning

confidence: 99%

Advantages of Tailored Isotretinoin Treatment in Moderate to Severe Acne: Real-Life Data

Skroza¹,

Tolino²,

Balduzzi³

et al. 2021

Front. Pharmacol.

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This retrospective single-center study analyzes the efficacy and safety of isotretinoin for the treatment of moderate to severe acne in real-life clinical practice, particularly with regard to acne severity, isotretinoin cumulative dosage, and patients’ gender. The results suggest the opportunity of an early isotretinoin systemic treatment in patients affected by moderate acne and emphasize the importance of an appropriate dose adjustment in order to minimize adverse events.

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Investigation of relapse rate and factors affecting relapse after oral isotretinoin treatment in patients with acne vulgaris

Cited by 7 publications

References 34 publications

Self-medication for acne among medical students on different academic levels in Riyadh, KSA 2022-2023

Self-medication for acne among medical students on different academic levels in Riyadh, KSA 2022-2023

Acne Vulgaris Relapse in Sudanese Patients Treated with Oral Isotretinoin: Rate and Predictive Factors

Advantages of Tailored Isotretinoin Treatment in Moderate to Severe Acne: Real-Life Data

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