Investigation of redox mechanism and DNA binding of novel 2-(x-nitrophenyl)-5-nitrobenzimidazole (x = 2, 3 and 4)

Exciton delocalization in a fully synthetic DNA-templated bacteriochlorin dimer

“…This assumption was further supported by the reported strong intercalating propensity of nitrophenyl ligands. 72 The absence of the observed coupling between the Q y transition and DNA was expected given the drastic difference in the Q y and DNA transition energies. Lastly, the monomer did not exhibit fluorescence even at a high sample concentration of 4 μM (Fig.…”

The link between relative stability constant of DNA- and BSA-chromenopyrimidine complexes and cytotoxicity towards human breast cancer cells (MCF-7)

“…Although it is unknown how substituents influence DNA binding, 63 their planarity due to the position of the nitro group could have led to their ease of accessing the DNA base pair pocket where intercalation with the DNA occurs. 64 The K BSA values for compounds containing electron-withdrawing substituents was found to increase in the following order: 5.86 × 10 4 M −1 ( 3g ) < 7.74 × 10 4 M −1 ( 3f ) < 1.64 × 10 5 M −1 ( 3h ) < 2.83 × 10 5 M −1 ( 3e ) < 3.29 × 10 5 M −1 ( 3c ) < 3.68 × 10 5 M −1 ( 3d ).…”

“…Although it is unknown how substituents inuence DNA binding, 63 their planarity due to the position of the nitro group could have led to their ease of accessing the DNA base pair pocket where intercalation with the DNA occurs. 64 The K BSA values for compounds containing electron-withdrawing substituents was found to increase in the following order: 5.86 × 10 4 M −1 (3g) < Considering that the ultimate target of our compounds is DNA, the binding constant (K DNA ) needs to be higher than that of BSA (K BSA ). Thus, an indicator that includes both biomolecules would be considered better with regards to biological activity and/or stability of test compounds.…”

What Can Electrochemical Methods Offer in Determining DNA–Drug Interactions?

“…The value of the binding constant is not the only factor used to assess the type of interactions. In addition, the direction of the signal shift on the voltammogram, with an increase in the DNA concentration, indicates the nature of the interactions [ 91 ]. In general, the positive shift (a shift toward higher potential values) is caused by the intercalation with DNA [ 92 ], while the negative shift is observed for the electrostatic interaction of a drug with DNA [ 93 ].…”