Investigation of red blood cells from patients with diffuse liver diseases by combined dielectrophoresis and terahertz spectroscopy method

Кручинина, М. В.; Gromov, Andrey; Кручинин, В. Н.; Генералов, В. М.; Николаев, Н. А.; Анцыгин, В. Д.; Minin, Igor V.; Minin, Oleg V.

doi:10.1117/1.oe.60.8.082003

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“…Hence, nowadays THz technology stands out as a competitive option for replacing or complementing other techniques that have proven to be harmful, such as X-rays. This facts, added to its strategic location in the middle of the EM spectrum that allows for an extrapolation of concepts borrowed from other bands, has led to a fast technological development of biosensing devices in this range, and the biological-related THz research activity has spread throughout the world covering a wide variety of fields such as diagnosis of diseases [100]- [103], detection of protein concentrations [104]- [106], DNA sequencing [107]- [109], detection of cancer cells and tumors [39], [110]- [113], or detection of microorganisms [114]- [118], among others. In this regard, metasurfaces are probably one of the most successful realizations, as they respond to changes in the refractive index of the device, a measurement that is relatively easy and cheap to perform, allowing for a quantitative and kinetic measurement of molecular interactions [119].…”

Section: Biological Sensing With Metasurfacesmentioning

confidence: 99%

Terahertz and infrared sensing with metasurfaces and spectroscopy techniques

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Metamaterials emerged in the early years of the 21st century as artificial materials with unusual parameters, presenting an exotic electromagnetic behavior, with more possibilities for the control of electromagnetic radiation. Since their first experimental realization, the research in the field of electromagnetism had a great momentum and, as a result, numerous designs based on metasurfaces (the planar version of metamaterials) have been proposed for various applications such as telecommunications, security, spectroscopy, imaging, or sensing, among others. This Thesis investigates the use of devices inspired by the metasurfaces paradigm for sensing applications, operating in the terahertz frequency regime. The content of the Thesis can be divided into three distinct parts that are related to the different studies carried out in these years. First, the numerical and experimental design of metasensors for thin films, biological and chemical samples sensing applications. For this purpose, two types of metasurface-based structures are presented: a design with a complicated geometry that allows obtaining results with high sensitivity, and a design based on hole arrays that exploits the phenomenon of extraordinary transmission. On the other hand, the effect of geometry on metasensor patterns and its influence on detection quality is investigated by geometrical modification of a very simple tripod-based design. Finally, the application of mid-infrared spectroscopy for the analysis of oxidative products in animal meat is investigated.

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Section: Biological Sensing With Metasurfacesmentioning

confidence: 99%

Terahertz and infrared sensing with metasurfaces and spectroscopy techniques

López¹

View full text Add to dashboard Cite

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Investigation of red blood cells from patients with diffuse liver diseases by combined dielectrophoresis and terahertz spectroscopy method

Cited by 1 publication

References 22 publications

Terahertz and infrared sensing with metasurfaces and spectroscopy techniques

Terahertz and infrared sensing with metasurfaces and spectroscopy techniques

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