Investigation of Reaction Mechanism of Amino Acids and Phosphorus Trichloride by ³¹ P NMR and ESI-MS/MS

Abstract

The reaction of amino acids and phosphorus trichloride in THF was studied by 31 P NMR tracing and ESI-MS/MS. A series of hydridophoranes and cyclic dipeptides were obtained. The reaction presented interesting diversity and the reaction mechanism was proposed. The mechanism suggests that phosphorus plays an important role in the synthesis of amino acid hydridophorane and cyclic dipeptides. The results also show that 31 P NMR and ESI-MS/MS are useful tools for the investigation of reaction mechanism.

Calculation Model and Application Research of Molar Formation Enthalpy for Real Gas

“…Relation of reaction heat and temperature is considered according to Kirchhoff's Law in reference [1], but effect of pressure is ignored. Reference [2] points that effect of pressure on reaction heat of idea gas and condensed phase is little, which can be ignored. Calculation model of reaction heat of real gas is established in reference [3], which has been simplified by Van der Waals equation, but the simplified equation has neglected temperature and pressure coupled interaction [4].…”