Investigation of rare earth elements in urine and drinking water of children in mining area

Qing-qing, Liang; Yin, Haijing; Li, Jianting; Zhang, Liping; Hou, Ruili; Wang, Suhua

doi:10.1097/md.0000000000012717

Cited by 25 publications

(9 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(Urine, blood, other)", rather than by reviewing laboratory results or including detail on the methodology used for any testing undertaken. Furthermore, although there are isolated reports quantifying urine gadolinium concentrations in biological matrices from healthy subjects [44][45][46][47], the data provided in these reports are insufficient to characterise a reference range and it is therefore challenging to interpret the results from blood and/or urine gadolinium concentration measurements.…”

Section: Methodsmentioning

confidence: 99%

Gadolinium-based contrast agents – what is the evidence for ‘gadolinium deposition disease’ and the use of chelation therapy?

Layne

Wood

2019

Clinical Toxicology

View full text Add to dashboard Cite

Introduction: Gadolinium-based contrast agents are widely used for magnetic resonance imaging and, until recently, had been generally considered to have an excellent safety profile in patients with normal renal function. Nephrogenic systemic fibrosis is a well-established disease process involving fibrosis of the skin and internal organs seen in some patients with severely impaired renal function following exposure to these agents. Following reports that individuals with normal renal function may experience gadolinium deposition within brain and bone tissue, the term "gadolinium deposition disease" has been proposed and the use of chelating agents has been recommended to treat this "disease". Objectives: This review will address the clinical evidence for "gadolinium deposition disease" and discuss whether chelation therapy is appropriate for individuals who believe they have this condition. Methods: Electronic databases (PUBMED, Ovid MEDLINE and EMBASE) were searched up to 1 st October 2019 for all studies evaluating clinical signs or symptoms related to potential gadolinium toxicity post-gadolinium-based contrast agent exposure in subjects with normal renal function, or papers evaluating the potential chelation of gadolinium in humans. Does "gadolinium deposition disease" exist as a novel condition? We identified four clinical studies relating to "gadolinium deposition disease", including one that included some discussion of the use of chelation therapy. Two of the clinical studies presented data from anonymous online surveys that recruited participants from support forums for people who self-identified as having gadoliniumbased contrast agent-induced toxicity, with questions focussing on their reported symptoms and signs. The published literature to date has demonstrated that gadolinium deposition within the brain primarily occurs within the dentate nucleus and globus pallidus. These patients did not complain of movement disorders, but instead reported generalised sensory symptoms, which would not be expected to occur with pathology in these areas of the brain. There was considerable selection bias and a lack of available clinical information to exclude alternative medical diagnoses for these series, thus rendering the results difficult to interpret. Role of chelation therapy in patients exposed to gadolinium-based contrast agent: One study reported data from 25 patients who were diagnosed with "gadolinium deposition disease" according to unspecified criteria and were treated with intravenous calcium or zinc trisodium pentetate. The authors reported an increase in urine gadolinium concentrations following administration of the chelating agents, which they attributed to re-chelation of gadolinium from tissue deposits, however, there are insufficient data to be able to substantiate this. Conclusion: There is currently no published information from well-designed clinical studies that support a link between gadolinium deposition and the development of clinical sequelae in patients with normal renal function. Clinic...

show abstract

Section: Methodsmentioning

confidence: 99%

Gadolinium-based contrast agents – what is the evidence for ‘gadolinium deposition disease’ and the use of chelation therapy?

Layne

Wood

2019

Clinical Toxicology

View full text Add to dashboard Cite

show abstract

“…Li et al (2017) found higher levels of La and Ce in the urine of the same kind of workers. The levels of Y, La, Ce, Pr, Nd, and Sm were higher in the urine of children living near the Bayan Obo mining area (Liang et al, 2018). Liu et al (2019) concluded that increased maternal urinary Ce and Yb level could be associated to decreased neonatal TSH levels.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of two methods for rare earth elements analysis in human urine samples using inductively coupled plasma-mass spectrometry

Brouziotis

Giarra

Marano

et al. 2022

Front. Environ. Sci.

View full text Add to dashboard Cite

The application of rare earth elements (REEs) in several areas, including high-tech technology, agriculture, medicine, and fuels, has made them an essential component of our everyday life. This extensive use of REEs in several technologies is expected to potentially impact human health. Even if several studies investigated the levels of REEs in human matrices, until now no standard method has been established for analyzing these elements in human matrices. The sample analysis should be of high quality, and the methods should be validated properly to ensure the quality of the procedure and traceability of the analytical data. In this research, we compared the validation and effectiveness of two different methods of sample preparation for human urine samples: a simple dilution of the sample (DIL) was compared with microwave assisted-acid decomposition (MIN) for tracing REE levels in human urine samples. The analysis was carried out by inductively coupled plasma mass spectrometry (ICP-MS). The working conditions have been set in high-sensitivity mode. Accuracy of the proposed method was evaluated by spiking the sample matrix with known concentrations of analyte standards. Both methods showed adequate precision of repeatability and intra-laboratory reproducibility, with the DIL method showing better precision of both repeatability and reproducibility than the MIN method. The CVr% values of repeatability range from 1.5 to 12% for the DIL and from 8.4 to 16% for the MIN method. The CVr% values of reproducibility range from 6.2–23% for the DIL and from 8.6 to 24% for the MIN method. REE recoveries for both methods were very close to 100%. Both methods proved to be effective for the determination of REE levels in human urine matrices.

show abstract

“…Notwithstanding the waste generated by beneficiation of RE-bearing ores, typically accomplished by froth floatation, the counter-current solvent extraction process for separating REs requires large volumes of solvent and produces substantial amounts of waste. Problems of environmental contamination have been reported adjacent to RE processing facilities. , Recently, a techno-economic analysis indicated that the cost to produce 1 kg of REO in a 66-stage facility using 1.0 M HEHEHP or 1.0 M Cyanex 572 was $2.46 and $1.35 USD, respectively, for a Yb:Lu separation, not including waste disposal or labor costs . The global market for REs is expected to reach $12.9 billion annually by 2025 .…”

Section: Introductionmentioning

confidence: 99%

Coordination Chemistry-Driven Approaches to Rare Earth Element Separations

et al. 2022

View full text Add to dashboard Cite

Conspectus Current projections for global mining indicate that unsustainable practices will cause supply problems for many elements, called critical raw materials, in the next 20 years. These include elements necessary for renewable technologies as well as artisanal sources. Energy critical elements (ECEs) comprise a group used for clean, renewable energy applications that are in low abundance in the Earth’s crust or require an economic premium to extract from ores. Sustainable practices of acquiring ECEs is an important problem to address through fundamental research to provide alternative energy technologies such as wind turbines and electric vehicles at cheaper costs for our global energy generation and usage. Some of these green technologies incorporate rare-earth (RE) metals (Sc, Y and the lanthanides), which are challenging to separate from mineral sources because of their similar sizes (i.e., ionic radii) and chemical properties. The current process used to provide REs at requisite purities for these applications is counter-current solvent–solvent extraction, which is scalable and works efficiently for any ore composition. However, this method produces large amounts of caustic waste that is environmentally damaging, especially to areas in China that house major separation facilities. Advancement of the selectivity of this process is challenging since exact molecular speciation that affords separations is still relatively unknown. In this context, we developed a program to investigate new RE separations systems that were aimed at minimizing solvent use, controlled by molecular speciation, and could be targeted at problems in recycling these critical metals. The first ligand system that was developed to impart solubility differences between light and heavy rare-earth ions was [{(2- t BuNO)C6H4CH2}3N]3– (TriNOx3–) (graphic below). A differential solubility allowed for a separation of Nd and Dy of SFNd:Dy = ∼300 in a single step. In other words, a 50:50 Nd/Dy sample was enriched to give 95% pure Nd and Dy through a simple filtration, which is potentially impactful to recycling magnetic materials found in wind turbines. This separations system compares favorably to other state-of-the-art molecular extractants that are based on energetic differences of the thermodynamic parameter to affect separations for neighboring elements. This straightforward, thermodynamically driven method to separate REs primed our future research for new coordination chemistry approaches to separations. Another separations system was accomplished through the variable rate of a redox event from one arm of the TriNOx3– ligand. It was determined that the rate of this one electron oxidation, which operated through an electrochemical-chemical-electrochemical mechanism, was dependent on the identity of the RE ion. This kinetically driven separation afforded a separation factor (SF) of SFEu:Y = 75. We have also described other transformations such as ligand exchange, substituent dependent, and redox-driven chelation processes with well-define...

show abstract

Investigation of rare earth elements in urine and drinking water of children in mining area

Cited by 25 publications

References 16 publications

Gadolinium-based contrast agents – what is the evidence for ‘gadolinium deposition disease’ and the use of chelation therapy?

Gadolinium-based contrast agents – what is the evidence for ‘gadolinium deposition disease’ and the use of chelation therapy?

Comparative study of two methods for rare earth elements analysis in human urine samples using inductively coupled plasma-mass spectrometry

Coordination Chemistry-Driven Approaches to Rare Earth Element Separations

Contact Info

Product

Resources

About