Investigation of radiosterilization and dosimetric features of sulfacetamide sodium

Çolak, Şeyda; Korkmaz, Mustafa

doi:10.1016/j.jpba.2004.08.036

Cited by 16 publications

(13 citation statements)

References 25 publications

(25 reference statements)

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“…The g values associated with low-field shoulder and negative lob of the central intense resonance line of irradiated SMH (Figure 2(e)), which were calculated to be 2.0093 and 2.0028, respectively, stay in this range. We believe, accordingly, that the SO − 2 ionic radical (hereafter, radical A) and molecular ionic fragment NH 2 O ± O S (hereafter, radical B) arising from the intense central resonance lines are produced in gamma-irradiated SMH as in other gamma-irradiated sulfonamides (1)(2)(3)(4). Radicals A and B are randomly oriented in polycrystalline SMH sample and the motion of radical B is restricted to a large extent due to the big group attached to it, so that it gives rise to powder ESR spectra with principal g values varying between g xx = 2.0022-2.0031, g yy = 2.0015-2.0098 and g zz = 2.0058-2.0066 (8,9).…”

Section: Proposed Radical Species and Simulation Of Room Temperature mentioning

confidence: 99%

“…Electron spin resonance (ESR) is a very suitable technique with which to investigate the characteristics of the radical species produced in samples after irradiation. The gamma radiation responses of different sulfonamides by the ESR technique have been reported in the literature (1)(2)(3)(4). The aim of this work is to investigate by ESR spectroscopy the radiosensitivity of SMH and to characterize the radiolytical intermediates produced in it after gamma irradiation in the dose range of 0.5-10 kGy, through detailed microwave saturation, kinetic and spectroscopic studies.…”

Section: Introductionmentioning

confidence: 99%

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ESR response of gamma-irradiated sulfamethazine

Çolak

Korkmaz

2009

Radiation Effects and Defects in Solids

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In the present work, characteristic features of the radiolytical intermediates produced in gamma-irradiated solid sulfamethazine (SMH) were investigated by electron spin resonance (ESR) spectroscopy. The heights of the resonance peaks, measured with respect to the spectrum baseline, were used to monitor microwave saturation, temperature and time-dependent kinetic features of the radical species contributing to the formation of recorded experimental ESR spectra. Three species having different spectroscopic and kinetic features were observed to be produced in gamma-irradiated SMH. SO 2 , which is the most sensitive group of radiation in the SMH molecule, was found to be at the origin of radiation-produced ionic radical species. Based on the experimental results derived from the present study, the applicability of ESR spectroscopy to radiosterilization of SMH was discussed. In the dose range of interest (0.5-10 kGy), the radiation yield of solid SMH was calculated to be very low (G = 0.45) compared with those obtained for sulfonamide aqueous solutions (G = 3.5-5.1). Based on these findings, it was concluded that SMH and SMH-containing drugs could be safely sterilized by gamma radiation and that ESR spectroscopy could be successfully used as a potential technique for monitoring their radiosterilization.

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Section: Proposed Radical Species and Simulation Of Room Temperature mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ESR response of gamma-irradiated sulfamethazine

Çolak

Korkmaz

2009

Radiation Effects and Defects in Solids

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“…ESR spektroskopisi ile iyonlaştırıcı radyasyon uygulaması sonucunda ilaç maddelerinde oluşan paramanyetik merkezlerin (serbest radikallerin) tespiti yapılabilir ve tek elektronun molekül üzerine yayılımı ile ilgili bilgi edinilebilir [1][2][3][4][5][6]. Daha önce ışınlanmış ilaç örnekleri üzerine yapılan çalışmaların sonuçları ESR spektroskopisinin ışınlama ile oluşan serbest radikallerin karakterizasyonunda…”

Section: Introductionunclassified

Klorpromazin İlaç Örneğinin Elektron Spin Rezonans Spektroskopisi ile Dozimetrik İncelenmesi

Işıkçı¹

2019

deufmd

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ÖzBu çalışmada, nörolojik hastalıkların tedavisinde kullanılan ilaç etkin madde Klorpromazin örneğinin dozimetrik malzeme olarak kullanıma uygunluğu, radikal sönüm bilgileri, mikrodalga güç değerlerinde doyum bilgileri ve doz-cevap eğrisi oda sıcaklığında araştırılmıştır. Klorpromazin örneği belli doz değerlerinde γ-ışınları ile ışınlanmış ve Elektron Spin Rezonans (ESR) spektrumları kaydedilmiştir. Işınlanmamış örneklerde ESR sinyali gözlenmemiştir. Spektrum simülasyonu (benzetişimi) yapılarak radyasyon sonucunda oluşan iki farklı türdeki radikalin spektroskopik ve yapısal özellikleri belirlenmiştir.

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“…Radiation sterilization is also recognized by all major pharmacopeias for pharmaceutical raw materials and their dosage forms are particularly recommended for thermolabile or chemically reactive samples that cannot be sterilized thermally or chemically. With its high penetration range, sterilization by gamma radiation offers some very important advantages such as the possibility of sterilization of drugs in their final packages (terminal sterilization), low-cost-effectivity, small temperature rise, low chemical reactivity, and ease of validity as the essential validation process is only based on time variable [3,5,[7][8][9][10][11][12][13][14][15][16][17][18]. Besides, radiation sterilization is accepted to be a clean, nonresidue-producing technology that is safe for the worker and the community.…”

Section: Introductionmentioning

confidence: 99%

Ionizing Radiation Used in Drug Sterilization, Characterization of Radical Intermediates by Electron Spin Resonance (ESR) Analyses

Çolak¹

2015

Evolution of Ionizing Radiation Research

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In this study, the feasibility of radiation sterilization of drugs/drug raw materials is investigated by using Electron Spin Resonance ESR spectroscopy. Experimental data and their theoretical correspondings are presented for Sulfanilamide S" , Sulfafurazole SFZ , Sulfatiazole STZ , Sulfacetamide Sodium SS , Sulfamethazine SMH , "utylated Hydroxyanisole "H" , and "lbendazole "L" . Unirradiated samples exhibited no ESR signal whereas the irradiated samples showed ESR spectra consisting of different number of resonance lines indicating that radiolytic intermediates were produced upon irradiation. Increase in the absorbed dose did not create any pattern change in the ESR spectra of these samples. The results of ESR microwave power studies indicated that saturation is observed to be faster for the studies held below room temperatures. Low radiation yield G= . -. calculated by ESR data for the gamma-irradiated samples showed that these materials can not be used as sensitive dosimetric materials. No significant differences were observed between FT-IR spectra of the unirradiated and irradiated samples and this result is considered to be in agreement with the relatively small G value derived from ESR studies. The decay rates of the ESR peak heights of the samples irradiated at different doses and stored at normal and stability conditions were found to be independent of the irradiation doses. The contributing radical species were determined to decay with different decay characteristics and the decay rates but decaying faster at stability conditions. The

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Investigation of radiosterilization and dosimetric features of sulfacetamide sodium

Cited by 16 publications

References 25 publications

ESR response of gamma-irradiated sulfamethazine

ESR response of gamma-irradiated sulfamethazine

Klorpromazin İlaç Örneğinin Elektron Spin Rezonans Spektroskopisi ile Dozimetrik İncelenmesi

Ionizing Radiation Used in Drug Sterilization, Characterization of Radical Intermediates by Electron Spin Resonance (ESR) Analyses

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