Investigation of Possible Pharmacokinetic Interaction Between Ivabradine and Carvedilol in Rats using High Performance Liquid Chromatography/Mass Spectroscopy

Abbas, Saif S; Al-Ani, Israa; Dayyih, Wael Abu; Oriquat, Ghaleb A.; Hassan, Samira F.

doi:10.13005/bpj/1375

Cited by 2 publications

(3 citation statements)

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“…Carivalan ® containing CAR and IVA has received a widespread indication for treating the symptoms of stable angina, where few analytical HPTLC [5] and HPLC [6,7] techniques for analyzing CAR and IVA have been stated. In the meantime, their simultaneous determination was achieved spectrophotometrically by only one reported research [8], while no spectrophotometric techniques have been previously conveyed for the declared drugs' resolving in the occurrence of their degradation products.…”

Section: Introductionmentioning

confidence: 99%

A unique revolutionary eco-friendly spectrophotometric technique for solving the spectral overlap in the determination of carvedilol and ivabradine in their binary combination: stability study

El Fiky,

Abd El Ghany,

Badawey

et al. 2024

Futur J Pharm Sci

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Background Carivalan® dosage form containing carvedilol and ivabradine is widely indicated for patients with stable angina. Three precise, eco-friendly and reproducible spectrophotometric techniques were created for resolving the researched drugs in their mixtures using zero and/or ratio spectra. Technique I is a factorized dual wavelength coupled with spectrum subtraction (FDW-SS), technique II is a ratio difference, and technique III is a constant center coupled with spectrum subtraction (CC-SS). Moreover, CAR and IVA were simultaneously determined in the existence of their oxidative degradation products exploiting the newly developed induced tripartite amplitude difference coupled with ratio subtraction (ITAD-RS) technique. Results The calibration curves for CAR and IVA showed linearity within 3.0–30.0 µg/ml, each. Techniques' precision, accuracy, and linearity ranges were resolved and validated in harmony with ICH guidelines. Additionally, the specificity was examined by examining created combinations of the proposed drugs with LOD of 0.258 and 0.290 for CAR, while for IVA 0.272 and 0.204. Conclusion These techniques were used to determine the presence of the provided drugs in Carivalan® tablets. There is statistical comparison between the found results of the offered spectrophotometric techniques and the previously reported ones with no discernible variance in the acquired results.

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Section: Introductionmentioning

confidence: 99%

A unique revolutionary eco-friendly spectrophotometric technique for solving the spectral overlap in the determination of carvedilol and ivabradine in their binary combination: stability study

El Fiky,

Abd El Ghany,

Badawey

et al. 2024

Futur J Pharm Sci

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“…ESZL, the S-isomer of omeprazole, is often more effective than other proton pump inhibitors currently available due to its favorable pharmacokinetic profile [3]. Several techniques have been used to estimate ESZL, including UV and RP-HPLC techniques [4][5][6][7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…There are no interactions between NPXN and ESZL in terms of pharmacokinetics. While the NPXN/ESZL tablet has the same bioequivalence as an entericcoated naproxen tablet, its esomeprazole bioavailability is lower than that of an entericcoated version [2,3,13,34]. Therefore, the objective of this study is to develop a chromatographic method for the simultaneous detection of ESZL and NPXN in Kleprum® tablets, which are sold in the Jordanian pharmaceutical market.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Naproxen and Esomeprazole in Bulk and Pharmaceutical Tablets Dosage Form by RP-Chromatography

2023

JPTCP

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An original, trustworthy, simple, precise, rapid, sensitive, and accurate RP-HPLC method was validated for quantifying naproxen and esomeprazole in both conventional and synthetic mixed formulation tablets. The maximum absorbances of Naproxen and Esomeprazole in a 60:40 (vol/vol) mixture of deionized water and methanol were 244.8 and 272.6nm, respectively. To isolate naproxen from esomeprazole, a Shimadzu LC-20-A RP-HPLC is employed equipped with a C18 Phenomenex column (250mm 4.6mm 5 µm). Elution was done with a methanol-water eluent (40:60 V/V). Both naproxen and esomeprazole were eluted within (3.468 and 5.376 min, respectively) after a 10-minute separation at 270 nm using a UV-Vis detector and a flow rate of 1.0 mL/min. Elution-phase conditions were studied, including elution-phase composition, flow rate, pH, and wavelength. Naproxen and esomeprazole both had linearity ranges of 0.5 -25 µg/mL and 0.1 -30 µg/mL, respectively, with R2 values of 0.9995 and 0.9997, and means of recovery of 99.57 and 100.36, respectively. The method was used to samples of medications in different dosage forms in order to determine their gradient active. The average recovery % was used to determine whether the technique was accurate, and it was determined to be within a reasonable range.

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Investigation of Possible Pharmacokinetic Interaction Between Ivabradine and Carvedilol in Rats using High Performance Liquid Chromatography/Mass Spectroscopy

Cited by 2 publications

References 0 publications

A unique revolutionary eco-friendly spectrophotometric technique for solving the spectral overlap in the determination of carvedilol and ivabradine in their binary combination: stability study

A unique revolutionary eco-friendly spectrophotometric technique for solving the spectral overlap in the determination of carvedilol and ivabradine in their binary combination: stability study

Evaluation of Naproxen and Esomeprazole in Bulk and Pharmaceutical Tablets Dosage Form by RP-Chromatography

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