Investigation of possible effect o f calcium carbimide on urinary oxalate excretion in primary hyperoxaluria.

Gibbs, Dorothy A.; Watts, R. W. E.

doi:10.1136/adc.43.229.313

Cited by 8 publications

(1 citation statement)

References 5 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patient 2 is an asymptomatic 11-year-old boy, previously studied by Gibbs & Watts (1968). He had no radiologically demonstrable urinary calculi; blood urea 36 mg/100 ml, inulin clearance 102 ml min-' 1.73 m-', PAH clearance 572 ml min-' 1.73 m-2.…”

Section: P a T I E N T S A N D M E T H O D Smentioning

confidence: 99%

The Action of Pyridoxine in Primary Hyperoxaluria

1970

View full text Add to dashboard Cite

S U M M A R Y1. Evidence of deficiency of, antagonism to, or abnormal dependency upon pyridoxine has been sought in four patients with primary hyperoxaluria. The urinary excretion of kynurenine, 3-hydroxykyurenineY 3-hydroxyanthranilic acid, kynurenic acid and xanthurenic acid, before and after a loading dose of L-tryptophan was used to assess pyridoxine nutrition.2. Three of the four patients studied had abnormal L-tryptophan metabolite excretion patterns, but these were not of the type which is associated with abnormalities of pyridoxine nutrition.3. The changes which were observed are compatible with impaired conversion of kynurenine to 3-hydroxykynurenine by the NADH, dependent kynurenine 3-hydroxylase (EC 1.99.1.5) enzyme system. 4. Large doses of pyridoxine hydrochloride reduced the urinary oxalate excretion by two of the patients to levels which were intermediate between the normal range and the pre-treatment values. This effect was maintained for 6 months, which was the longest period of observation. 5.It is concluded that this action of pyridoxine is mediated by a mechanism which does not involve the correction of an abnormality of pyridoxine metabolism.Primary hyperoxaluria, in which calcium oxalate urolithiasis is accompanied by an elevated urinary oxalate excretion, accounts for only a small proportion of patients with calcium oxalate urinary stones. The urinary oxalate excretion is increased in severe experimentally induced pyridoxine deficiency in man (Faber et al., 1963) as well asin animals (Gershoff et al., 1959a; Andrus, Gershoff k Faragella, 1959), andGershoff, Mayer &Kulczycki (1959b) reported that pyridoxine reduced the urinary oxalate excretion of a group of institutionalized mental defectives who were not taking a pyridoxine deficient diet.Mayer et al. (1968) implicated pyridoxine deficiency as a factor in the causation of calcium

show abstract

Section: P a T I E N T S A N D M E T H O D Smentioning

confidence: 99%

The Action of Pyridoxine in Primary Hyperoxaluria

1970

View full text Add to dashboard Cite

show abstract

Successful Renal Transplantation in Hyperoxaluria

Morgan¹,

Hartley²,

Miller³

et al. 1974

Arch Surg

View full text Add to dashboard Cite

Calciumcyanamid [MAK Value Documentation in German language, 1979]

2012

The MAK‐Collection for Occupational Health and Safety

View full text Add to dashboard Cite

Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 7. Lieferung, Ausgabe 1979 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Erfahrungen beim Menschen Lokale Einwirkung Systemische Einwirkung „Kalkstickstoff‐Krankheit“ Störungen nach langfristigem Kontakt Letale Dosis Therapeutische Erfahrungen Tierversuche Begründung des MAK‐Wertes

show abstract

Investigation of possible effect o f calcium carbimide on urinary oxalate excretion in primary hyperoxaluria.

Cited by 8 publications

References 5 publications

The Action of Pyridoxine in Primary Hyperoxaluria

The Action of Pyridoxine in Primary Hyperoxaluria

Successful Renal Transplantation in Hyperoxaluria

Calciumcyanamid [MAK Value Documentation in German language, 1979]

Contact Info

Product

Resources

About