Investigation of plant extracts in traditional medicine of the Brazilian Cerrado against protozoans and yeasts

Albernaz, Lorena Carneiro; Paula, José Elías de; Romero, Gustavo Adolfo Sierra; Silva, Maria do Rosário Rodrigues; Grellier, Phillipe; Mambu, Lengo; Espindola, Laïla Salmen

doi:10.1016/j.jep.2010.06.011

Cited by 54 publications

(32 citation statements)

References 37 publications

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“…As observed in the present study, several species of genus Calophyllum showed inhibitory potency against S. aureus [12,13] . The antimicrobial activity of C. inophyllum sourced from other locales are already acknowledged by many authors [14][15][16] .…”

Section: Discussionsupporting

confidence: 82%

An in vitro efficacy validation of mangrove associates

2014

JCLM

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Section: Discussionsupporting

confidence: 82%

An in vitro efficacy validation of mangrove associates

2014

JCLM

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“…A coumarin was isolated from this extract and its derivatives showed significant activity against L. amazonensis, with IC 50 between 0.6 and 34.0 µg/mL (Brenzan et al, 2007;Brenzan et al, 2008). On other hand, the extract from roots of C. brasiliense was active against L. chagasi and Plasmodium falciparum, with an IC 50 of 6.7 and 27.6 g/mL, respectively (Albernaz et al, 2010). Other study reported the purification of three xanthones from heartwood, which exhibited activity against epimastigote forms of Trypanosoma cruzi (Abe et al, 2004).…”

Section: Resultsmentioning

confidence: 95%

Antileishmanial activity of leaf extract from Calophyllum rivulare against Leishmania amazonensis

Oubada

García

Bello

et al. 2014

Emir. J. Food Agric

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Calophyllum rivulare is an endemic tree from Cuba that belongs to Clusiaceae family. This plant had revealed it to be a rich source of pyranochromanone acids including compounds with a variety of biological potentialities such as antioxidant, antiulcer, anticancer and anti-Helicobacter pylori activities. Herein, antileishmanial and cytotoxic activities of extracts obtained from C. rivulare leaves (rich in pyranochromanone acids) and amentoflavone were compared. Extracts were prepared by maceration employing ethyl acetate (CR-1) and methanol (CR-2) as solvents and amentoflavone was isolated from both extracts. The CR-2 extract showed the better activity against the parasite, with an IC 50 value of 95.1 ± 5.4 µg/mL and 20.6 ± 1.4 µg/mL against promastigote and amastigote forms, respectively. This extract showed lower cytotoxicity (IC 50 =182.4 ± 2.3 µg/mL) against peritoneal macrophage from BALB/c mice and a selectivity index of 9. Amentoflavone showed an IC50 of 5.9 ± 0.3 µg/mL against amastigote form and a selectivity index of 9. Results suggest that CR-2 extract and amentoflavone could be explored as new antileishmanial alternatives.

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“…Eugenol was found to completely inhibit the bacteria at a concentration of double the MIC (4 mg/mL) in about 1 h of incubation at acidic pH MIC of eugenol: 2 mg/ mL Ali et al (2005) Geranium DOI: 10.3109/13880209.2014.952837 ailments including rheumatism, varicose, hemorrhoids, and chronic ulcers (Sartori et al, 1999). The activity against protozoans and human pathogenic yeasts (Albernaz et al, 2010), cancer chemopreventive properties, antifungal (RuizMarcial et al, 2007;Suffredini et al, 2007), antisecretory, antiulcer (Sartori et al, 1999), gastroprotective (ReyesChilpa et al, 2006), and analgesic activities (da Silva et al, 2001) have been reported in different studies. Souza et al (2009) evaluated the effects of various extracts of C. brasiliense stem bark, against H. pylori in vivo and in vitro.…”

Section: Cocculus Hirsutusmentioning

confidence: 99%

Medicinal plants in the treatment ofHelicobacter pyloriinfections

Safavi

Shams-Ardakani

Foroumadi

2014

Pharmaceutical Biology

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Context: Helicobacter pylori is a small, spiral, Gram-negative bacillus that plays a role in the pathogenesis of a number of diseases ranging from asymptomatic gastritis to gastric cancer. Schedule compliance, antibiotic drug resistance, and side-effects of triple or quadruple therapy have led to research for novel candidates from plants.Objective: The purpose of this paper is to review the most potent medicinal plants of recently published literature with anti-H. pylori activity. For centuries, herbals have been used by traditional healers around the world to treat various gastrointestinal tract disorders such as dyspepsia, gastritis, and peptic ulcer disease. The mechanism of action by which these botanicals exert their therapeutic properties has not been completely and clearly elucidated. Anti-H. pylori properties may be one of the possible mechanisms by which gastroprotective herbs treat gastrointestinal tract disorders. Materials and methods: Electronic databases such as PubMed, Google scholar, EBSCO, and local databases were explored for medicinal plants with anti-H. pylori properties between 1984 and 2013 using key words ''medicinal plants'' and ''Helicobacter pylori'' or ''anti-Helicobacter pylori''. Results: A total of 43 medicinal plant species belonging to 27 families including Amaryllidaceae,

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Investigation of plant extracts in traditional medicine of the Brazilian Cerrado against protozoans and yeasts

Abstract: The active extracts for protozoans and human pathogenic yeasts are considered promising to continue the search for the identification and development of leading compounds.

Cited by 54 publications

References 37 publications

An in vitro efficacy validation of mangrove associates

An in vitro efficacy validation of mangrove associates

Antileishmanial activity of leaf extract from Calophyllum rivulare against Leishmania amazonensis

Medicinal plants in the treatment ofHelicobacter pyloriinfections

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