Investigation of phenolic contents and bioactivities of water-based extracts prepared from cryogenically pulverized Turkish propolis

Omer, Hiba-H. S.; Demirtaş, İbrahim; Özen, Tevfik

doi:10.1007/s11694-022-01716-4

Cited by 2 publications

(1 citation statement)

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“…Propolis contains high polyphenolic compounds and is used to treat various disorders. In many countries, propolis is used in traditional medicine, cosmetics, and food industries (Omer et al., 2023 ; Viuda‐Martos et al., 2008 ). It has also many pharmacological activities such as antioxidants (Ding et al., 2021 ), antimicrobial (Abdullah et al., 2020 ), antiamoebic (Zullkiflee et al., 2023 ), antidiabetic, antihypertensive (Farida et al., 2023 ), antiviral (Ożarowski & Karpiński, 2023 ), anti‐inflammatory (El‐Guendouz et al., 2017 ), anti‐allergic, hepatoprotective (Kolankaya et al., 2002 ), analgesic–anesthetic activity (Orsatti & Sforcin, 2012 ), immuno‐modulatory (Zullkiflee et al., 2022 ), and anticancer properties (Campoccia et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Isolation of phenolic compounds from eco‐friendly white bee propolis: Antioxidant, wound‐healing, and anti‐Alzheimer effects

Necip,

Demirtas,

Tayhan

et al. 2023

Food Science & Nutrition

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This study presents the first findings regarding extraction, isolation, enzyme inhibition, and antioxidant activity. The oral mucosal wound‐healing process was investigated using propolis water extract (PWE) incubation with gingival fibroblast cells and concluded that propolis was effective on the oral mucosal wound‐healing pattern compared to untreated controls. Additionally, phenolic compounds (fraxetin, apigenin, galangin, pinobanksin, chrysin, etc.) were isolated from propolis, and their chemical structures were elucidated using comprehensive spectroscopic methods. The antioxidant and anti‐Alzheimer potential activities of PWE and some isolated compounds were screened and revealing their inhibitory effects on acetylcholinesterase (AChE) with IC50 values ranging from 0.45 ± 0.01 to 1.15 ± 0.03 mM, as well as remarkable free‐radical scavenging and metal reduction capacities. The results suggest that these compounds and PWE can be used as therapeutic agents due to their antioxidant properties and inhibitory potential on AChE. It can also be used for therapeutic purposes since its wound‐healing effect is promising.

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