Investigation of periodontal ligament reaction upon excessive occlusal load – osteopontin induction among periodontal ligament cells

Kaku, Masaru; Uoshima, Katsumi; Yamashita, Yasuo; Miura, Hiroyuki

doi:10.1111/j.1600-0765.2004.00773.x

Cited by 56 publications

(57 citation statements)

References 53 publications

(51 reference statements)

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“…In a rat model where occlusal trauma was initiated by raising the occlusal surface, immunohistochemistry demonstrated RANKL associated with osteoclasts and osteoblasts. 34 A similar occlusal trauma protocol combined with lipopolysaccharide-induced periodontitis extended the length of time that osteoclasts were present on the interproximal bone surface, and the increased expression of RANKL in osteoclasts, endothelial cells, inflammatory cells, and periodontal ligament cells. 35 Human periodontal ligament cells exposed to mechanical stress also increased interleukin-6 production, a potent stimulator of RANKL, periodontal inflammation, and bone resorption.…”

Section: Potential Indications and Scientific Rationale For Reducing mentioning

confidence: 98%

Do Mobility and Occlusal Trauma Impact Periodontal Longevity?

Reinhardt

Killeen

2015

Dental Clinics of North America

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Section: Potential Indications and Scientific Rationale For Reducing mentioning

confidence: 98%

Do Mobility and Occlusal Trauma Impact Periodontal Longevity?

Reinhardt

Killeen

2015

Dental Clinics of North America

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“…Due to ethical limitations on prospective evaluation of OT in humans, 2 experimental models in rats were developed for the present study, with the goal of evaluating the consequence of the type of occlusion on the development of bone loss in primary OT. In one of the models, occlusal interference 7,8,11 was created to imitate experimentally the occlusal interferences and premature occlusal contacts that lead to the increase in the vertical dimension of occlusion, leading to occlusal instability by altering the force vectors and changing the magnitude of the applied forces to one tooth. In the other model, the unilateral vertical dimension was reduced, creating occlusion on only one of the first molars, with the goal of reproducing experimentally the cases of partial edentulism 15 , also creating occlusal overload experimentally.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have been conducted with the aim of understanding the cellular, molecular and genetic mechanisms involved in occlusal trauma [7][8][9][10][11] . Clinically, however, there is an ethical implication that limits the conduct of prospective studies on occlusal trauma in humans, making it difficult to measure occlusal overload and its implications on bone, cementum and the periodontal ligament 12,13 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of bone loss due to primary occlusal trauma in two experimental models of occlusal overload

Lopes

Téo

Corrêa

et al. 2016

Rev. odontol. UNESP

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ResumoIntrodução: Trauma oclusal primário (TO) é a injúria causada no periodonto de inserção de dentes com periodonto de altura normal devido a forças oclusais que excedem sua capacidade adaptativa. Objetivo: Avaliar histometricamente a reabsorção óssea alveolar na região da furca do 1º molar inferior em ratos submetidos experimentalmente a 2 modelos de sobrecarga oclusal. Material e método: 45 animais aleatoriamente divididos em 3 Grupos: Interferência Oclusal (GI, n = 15) -fixação de um segmento de fio ortodôntico na face oclusal do 1º molar inferior; Sobrecarga Oclusal (GS, n = 15) -desgaste das cúspides dos molares inferiores contralaterais e dos 2º e 3º molares do lado do 1º molar que teve suas dimensões mantidas; Grupo Controle Negativo (CN, n = 15) -avaliação das dimensões iniciais do ligamento periodontal. Cinco animais/grupo foram submetidos à eutanásia após 14, 21 e 28 dias. Resultado: A avaliação intergrupos mostrou que houve reabsorção óssea significativa em GI (p<0,001) e GS (p<0,01) quando comparados com CN. O grupo GI teve reabsorção óssea significativamente maior quando comparado ao grupo GS em 14 (p<0,01), 21 (p<0,01) e 28 dias (p<0,01). A avaliação intragrupos não mostrou influência significativa do tempo na reabsorção óssea em GI e GS, independente da técnica utilizada (p>0,05). A espessura do ligamento periodontal manteve-se estável no grupo CN (p>0,05). Conclusão: GI e GS foram eficazes na reprodução experimental do TO e GI promoveu maior reabsorção óssea alveolar quando comparado a GS, mostrando que o impacto causado pela sobrecarga oclusal no grupo GI aumentou a lesão por TO.Descritores: Reabsorção óssea; oclusão dental; ferimentos e lesões; ratos. AbstractIntroduction: Primary occlusal trauma (OT) is an injury of the periodontium with normal height as a result of occlusal forces which exceed their adaptive capacity. Objective: To evaluate, histometrically, the alveolar bone loss in the furcation region of rats experimentally submitted to 2 models of occlusal overload. Material and method: 45 animals randomly divided into 3 groups: Occlusal Interference (OI, n = 15) -fixing an orthodontic wire segment on the occlusal surface of the first lower molar; Occlusal Overload (OO, n = 15) -wearing of the cusps of the lower contralateral molars, the second and third molars next to the first molar that had its dimensions maintained; Negative Control (NC, n = 15) -evaluation of the initial dimensions of the periodontal ligament (PL). Five animals / group were sacrificed after 14, 21 and 28 days. Result: Intergroup evaluation showed significant bone loss in OI (p<0.001) and OO (p<0.01) compared to NC. OI had significantly higher bone loss compared to OO at 14 (p<0.01), 21 (p <0.01) and 28 days (p<0.01). The intragroup evaluation showed no significant influence of time on bone loss in OI and OO, regardless of the technique used (p>0.05). The thickness of the PL remained stable in NC (p>0.05). Conclusion: OI and OO were effective in the experimental reproduction of OT, and OI promoted greater alveolar b...

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“…1 Periodontal breakdown is most evident in abutment teeth that support various types of partial prostheses. 2 Many clinical studies have recommended appropriate prosthesis designs and long-term recall and maintenance to prevent periodontal breakdown.…”

Section: Introductionmentioning

confidence: 99%

Fifteen years of follow-up of a removable prosthetic design to maintain two remaining molars in a patient with mandibular reconstruction

Hsu

2012

Journal of Dental Sciences

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This clinical report describes a long-term prosthetic solution for a patient who had undergone mandibular reconstruction with a fibular graft, leaving only two right molars. The only retention device for the removable prosthesis design included a telescoping system with an O-ring application, but without fibula graft involvement. This prosthesis design was motivated by the altered bony and muscular architecture resulting in an increased maxillomandibular space and thick soft tissue in the denture-bearing area. This case demonstrates that appropriate denture design, consistent recall maintenance, and oral hygiene motivation minimized periodontal destruction and maximized prosthetic use for the patient despite the unfavorable loading conditions.

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Investigation of periodontal ligament reaction upon excessive occlusal load – osteopontin induction among periodontal ligament cells

Cited by 56 publications

References 53 publications

Do Mobility and Occlusal Trauma Impact Periodontal Longevity?

Do Mobility and Occlusal Trauma Impact Periodontal Longevity?

Evaluation of bone loss due to primary occlusal trauma in two experimental models of occlusal overload

Fifteen years of follow-up of a removable prosthetic design to maintain two remaining molars in a patient with mandibular reconstruction

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