Investigation of percutaneous ultrasonographycally guided ethanol injection therapy (PEIT) for treatment of small hepatocellular carcinoma.

Fujimoto, Takafumi; Matsumoto, Yasuo; Tanaka, Masatoshi; Iwai, I; Sakai, Terufumi; Hirai, Kenji; Abe, Masahide; Tanikawa, Kyuichi; Kenmochi, Kunihiro

doi:10.2957/kanzo.27.1559

Cited by 9 publications

(1 citation statement)

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“…Eleven of the 2 1 patients who underwent reresection died eventually; the median survival time calculated from the time of reresection of these 2 I patients was 36 months (range, 6-120). It was 10 months (range, [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] in patients without reresection calculated from the time of diagnosis to recurrence.…”

Section: Resultsmentioning

confidence: 99%

Surgery of small hepatocellular carcinoma. Analysis of 144 cases

Tang

Zhou

et al. 1989

Cancer

128

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A long-term follow-up study of 144 cases with surgically and pathologically proved small hepatocellular carcinoma (less than or equal to 5 cm) from 1967 to 1987 is reported. One hundred eight cases (75.0%) were detected by alpha-fetoprotein serosurvey and/or ultrasonography mainly in a high-risk population; 129 cases (89.6%) coexisted with cirrhosis. Resection was done in 132 cases (91.7%) with three (2.3%) operative deaths; cryosurgery, laser vaporization, and hepatic arterial chemotherapy were used in the rest. Limited resection was done in 67.4% of resections. Reresection of subclinical recurrence or solitary pulmonary metastasis was done in 21 cases. The 5-year and 10-year survival rates were 67.9% and 53.4% in the resection group but zero in the nonresection group. Survival was correlated negatively with tumor size, 5-year survival after resection was 84.6% in tumors less than or equal to 2 cm but 59.5% in tumors of 4.1 to 5 cm. The increase of resectability and reresection resulted in marked improved of 5-year survival from 43.5% in 1973 to 1977 to 63.3% in 1978 to 1982 in the entire series. No significant difference was found between survival of limited resection and lobectomy. Resection may be the modality of choice for treatment of small hepatocellular carcinomas with compensated liver function. Limited resection instead of lobectomy was the key to increased resectability and decreased operative mortality in cirrhotic livers. Reresection of subclinical recurrence was important to prolong survival further.

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Section: Resultsmentioning

confidence: 99%

Surgery of small hepatocellular carcinoma. Analysis of 144 cases

Tang

Zhou

et al. 1989

Cancer

128

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Role of interstitial therapy in the treatment of liver cancer

Masters

Steger

Bown

1991

Journal of British Surgery

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Conventional palliative management of inoperable focal hepatic tumours remains unsatisfactory. Interstitial techniques such as cryotherapy, alcohol injection, low power laser hyperthermia and interstitial radiotherapy offer alternative approaches. Cryotherapy is an effective and precise technique for inducing tumour necrosis. It can only be performed at laparotomy making it relatively invasive and retreatment impractical. Alcohol is cheap and can be injected percutaneously. However, inhomogeneous distribution produces imprecise and nonreproducible lesions. Low power laser hyperthermia produces precise and reproducible areas of necrosis that are roughly spherical in shape. At present, this technique is most effective for small tumours. Interstitial radiotherapy remains the least evaluated of all the interstitial techniques. Unlike cryotherapy and low power laser hyperthermia, the biological effect of ethanol injection and interstitial radiotherapy cannot be monitored in real time by ultrasound. With the exception of cryotherapy, all methods can be applied percutaneously with low morbidity and mortality. None of these techniques is established, but they may offer the prospect of cure in cases where all areas of tumour can be positively identified and fully treated. However, in most instances the intention is to control the growth of relatively small discrete volumes of tumour within the hepatic parenchyma.

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Multidisciplinary treatment of hepatocellular carcinoma

Tanikawa

1992

Primary Liver Cancer in Japan

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Investigation of percutaneous ultrasonographycally guided ethanol injection therapy (PEIT) for treatment of small hepatocellular carcinoma.

Cited by 9 publications

References 0 publications

Surgery of small hepatocellular carcinoma. Analysis of 144 cases

Surgery of small hepatocellular carcinoma. Analysis of 144 cases

Role of interstitial therapy in the treatment of liver cancer

Multidisciplinary treatment of hepatocellular carcinoma

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