Investigation of pectin/starch hydrogel as a carrier for oral delivery of probiotic bacteria

Dafe, Alireza; Etemadi, Hossein; Dilmaghani, Azita; Mahdavinia, Gholam Reza

doi:10.1016/j.ijbiomac.2017.01.060

Cited by 173 publications

(85 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In biomedical applications, pectin hydrogels are primarily used as drug delivery systems, such as those for pharmaceutical compounds and probiotics . In tissue engineering, pectin hydrogels have been applied for the isolation of wound surfaces, as a barrier to prevent postoperative adhesion, as an extracellular matrix for reconstructing bone tissue and as a coating for hard tissue implants .…”

Section: Discussionmentioning

confidence: 99%

Mechanical properties, structure, bioadhesion, and biocompatibility of pectin hydrogels

Markov

Krachkovsky

Durnev

et al. 2017

J Biomedical Materials Res

View full text Add to dashboard Cite

The surface structure, biocompatibility, textural, and adhesive properties of calcium hydrogels derived from 1, 2, and 4% solutions of apple pectin were examined in this study. An increase in the pectin concentration in hydrogels was shown to improve their stability toward elastic and plastic deformation. The elasticity of pectin hydrogels, measured as Young's modulus, ranged from 6 to 100 kPa. The mechanical properties of the pectin hydrogels were shown to correspond to those of soft tissues. The characterization of surface roughness in terms of the roughness profile (Ra) and the root-mean-square deviation of the roughness profile (Rq) indicated an increased roughness profile for hydrogels depending on their pectin concentration. The adhesion of AU2% and AU4% hydrogels to the serosa abdominal wall, liver, and colon was higher than that of the AU1% hydrogel. The adhesion of macrophages and the non-specific adsorption of blood plasma proteins were found to increase as the pectin concentration in the hydrogels increased. The rate of degradation of all hydrogels was higher in phosphate buffered saline (PBS) than that in DMEM and a fibroblast cell monolayer. The pectin hydrogel was also found to have a low cytotoxicity. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2572-2581, 2017.

show abstract

Section: Discussionmentioning

confidence: 99%

Mechanical properties, structure, bioadhesion, and biocompatibility of pectin hydrogels

Markov

Krachkovsky

Durnev

et al. 2017

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…Likewise, potential industrial uses of these polysaccharide combinations are include, as water soluble pouches for detergents and insecticides, flushable liners and bags, and in food industry as edible bags for soup and noodle ingredients [ 274 ]. Dafe et al [ 275 ] lead an investigation on the encapsulation of probiotics ( Lactobacillus plantarum ) in a pectin/starch hydrogel by an extrusion method. The entrapment of probiotics in the matrix was successful and resisted the simulated gastric conditions, increasing the tolerance of L. plantarum to the strong acidic media.…”

Section: Pectin Compositesmentioning

confidence: 99%

Pectin and Pectin-Based Composite Materials: Beyond Food Texture

et al. 2018

View full text Add to dashboard Cite

Pectins are plant cell wall natural heteropolysaccharides composed mainly of α-1-4 d-galacturonic acid units, which may or may not be methyl esterified, possesses neutral sugars branching that harbor functional moieties. Physicochemical features as pH, temperature, ions concentration, and cosolute presence, affect directly the extraction yield and gelling capacity of pectins. The chemical and structural features of this polysaccharide enables its interaction with a wide range of molecules, a property that scientists profit from to form new composite matrices for target/controlled delivery of therapeutic molecules, genes or cells. Considered a prebiotic dietary fiber, pectins meetmany regulations easily, regarding health applications within the pharmaceutical industry as a raw material and as an agent for the prevention of cancer. Thus, this review lists many emergent pectin-based composite materials which will probably palliate the impact of obesity, diabetes and heart disease, aid to forestall actual epidemics, expand the ken of food additives and food products design.

show abstract

“…Compared to the chemical methods that need harsh conditions such as high pressure and temperature, using of microorganism is considered in many purposes including heavy metal absorption, 1 gene engeering, 2 digestion, 3 production of novel anti-microbs 4 and particullary for producing of industrial enzymes. 5 , 6 Demand on the high-quality productions leads to development of novel methods to improve industrial products such as protease and amylase that are frequently applied in industry and medical science.…”

Section: Introductionmentioning

confidence: 99%

Microbial Alpha-Amylase Production: Progress, Challenges and Perspectives

et al. 2020

Self Cite

View full text Add to dashboard Cite

Alpha-amylase reputes for starch modification by breaking of 1-4 glycosidic bands and is widely applied in different industrial sectors. Microorganisms express unique alpha-amylases with thermostable and halotolerant characteristics dependent on the microorganism’s intrinsic features. Likewise, genetic engineering methods are applied to produce enzymes with higher stability in contrast to wild types. As there are widespread application of α-amylase in industry, optimization methods like RSM are used to improve the production of the enzyme ex vivo. This study aimed to review the latest researches on the production improvement and stability of α-amylase.

show abstract

Investigation of pectin/starch hydrogel as a carrier for oral delivery of probiotic bacteria

Cited by 173 publications

References 39 publications

Mechanical properties, structure, bioadhesion, and biocompatibility of pectin hydrogels

Mechanical properties, structure, bioadhesion, and biocompatibility of pectin hydrogels

Pectin and Pectin-Based Composite Materials: Beyond Food Texture

Microbial Alpha-Amylase Production: Progress, Challenges and Perspectives

Contact Info

Product

Resources

About