Investigation of pathological and clinical features of lupus nephritis in 73 autopsied cases with systemic lupus erythematosus

Abstract

The aims of this study were to analyze the clinical and pathological features of lupus nephritis (LN) and examine the association between these features and pathological condition, treatment, and prognosis. Of the 177 systemic lupus erythematosus patients who died while receiving inpatient care at Juntendo University Hospital between 1960 and 2001, we investigated the clinical features, treatment, and pathological features of 73 of these who underwent pathological autopsy and had a clear medical history. We divided these cases into two groups, i.e., those up to 1979 (Group A) and those during and after 1980 (Group B) in order to investigate changes in tendencies by age. We also divided the cases into three groups by time interval between diagnosis and death to investigate long-term prognosis. Uremia was the direct cause of death in 38.9% of cases in Group A and only 10.8% of cases in Group B. Pathological features showed a tendency to change to a sclerotic lesion as the duration of the disorder became longer. Uremia attributable to LN was the direct cause of death in relatively fewer cases, although it is still found in the majority of LN cases and remains a problem requiring stringent management. The treatment of sclerotic lesions may be an issue that needs further attention.

The clinico-pathological features of lupus nephritis and the significance of ISN/RPS-2003 Class IV lesions

“…anti ds-DNA positivity was in concordance with similar studies reiterating the sensitivity of these markers in lupus nephritis (7,9). A neurological Paper Journal of Diagnostic Pathology 2014;9(2):14-22 disorder was found in a very small number of our patients, although it has been reported to be commoner in western studies (10,11).…”

The safety and efficacy of biologic agents in treatment of systemic lupus erythematosus: A network meta-analysis

“…The SLE is caused by immune complexes depositing on organs and extensive injury were caused 7. The patients with SLE are characterized by BCR-initiated signaling and IL-6 production, including alter in B cell subset distribution 8.…”

Lupus nephritis in the XXI century

“…Развивается ВН примерно у 40-50% пациентов, в большинстве случаев на ранних стадиях СКВ (в течение первых 6-36 мес), но может манифестировать уже в дебюте заболевания [1][2][3]. По данным аутопсий ВН обнаруживается гораздо чаще: почти у 95% пациентов с СКВ [4], а отложения иммунных комплексов в ткани почек выявляются практически у всех больных СКВ даже в отсутствие каких-либо изменений при светооптической микроскопии [5].…”