Investigation of Paracetamol Entrapped Nanoporous Silica Nanoparticles in Transdermal Drug Delivery System

Adhikary, Sourav; Hoque, Ashique Al; Ray, Manju; Paul, Swastik; Hossain, Akbar; Goswami, Subrata; Dey, Rajib

doi:10.1007/s12010-023-04576-w

Cited by 2 publications

(1 citation statement)

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“…However, use of an inappropriate dosage or continuous use of the drug may lead to patient overdose. The recommended dosage of this drug is 500-1000 mg every 4-6 h, with a maximum of 4000 mg every 24 h for both adults and children (≥12 years) [2]. Excess AP can cause acute liver damage.…”

Section: Introductionmentioning

confidence: 99%

Development of Efficient Sodium Alginate/Polysuccinimide-Based Hydrogels as Biodegradable Acetaminophen Delivery Systems

Trinh,

Lim,

Lee

et al. 2023

Gels

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Efficient drug delivery systems are essential for improving patient outcomes. Acetaminophen (AP), which is a kind of oral administration, is a commonly used pain reliever and fever reducer. However, oral administration carries various health risks, especially overdose and frequent use; for instance, AP is administered approximately 4 times per day. Therefore, the aim of this study is to develop an efficient delivery system for once-daily administration by combining sodium alginate and polysuccinimide (PSI) hydrogels to delay the release of analgesic AP. PSI is a biodegradable polymer that can be used safely and effectively in drug delivery systems because it is eliminated by hydrolysis in the intestine. The use of PSI also improves the mechanical properties of hydrogels and prolongs drug release. In this study, hydrogel characterizations such as mechanical properties, drug dissolution ability, and biodegradability were measured to evaluate the hydrolysis of PSI in the intestine. Based on the results, hydrogels could be designed to improve the structural mechanical properties and to allow the drug to be completely dissolved, and eliminated from the body through PSI hydrolysis in the intestines. In addition, the release profiles of AP in the hydrogels were evaluated, and the hydrogels provided continuous release of AP for 24 h. Our research suggests that sodium alginate/PSI hydrogels can potentially serve as biodegradable delivery systems for AP. These findings may have significant implications for developing efficient drug delivery systems for other classes of drugs.

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Section: Introductionmentioning

confidence: 99%